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Professor Yubin Ding
Time:2016-07-06
 

NAME:  Yubin Ding

  

PERSONAL INFORMATION:

Work address:The School of Public Health, Chongqing Medical Center

No. 1, Yixueyuan Rd, Chonqing ,P. R. China 400016

  

Phone:132 2029 3739 (cell)

  

Email:178384198@qq.com

  

Home address:Apartment 1, No. 8 Yixueyuan Rd, Chonqing ,P. R. China

  

EDUCATION:

09/01/2008-07/01/2012Ph.D. ofLaboratory Medicine

Chongqing Medical University, Chonqing, P.R. China

09/01/2002-07/01/2005Master of Cytobiology

Southwest Agriculture University, Chonqing, P.R. China

09/01/1998-07/01/2002Bachelor of Plant Protection

Southwest Agriculture University, Chonqing, P.R. China

  

PROFESSIONAL EXPERIENCE:

02/20/2016-presentVisiting Scholar

The Department of OB&GYN and Reproductive Sciences,

University of Pittsburgh, Pittsburgh, PA

  

10/01/2012-presentAssociate Professor

The Department of Public Health, The Chongqing Medical

University, Chongqing, P.R. China

  

03/30/2015-02/19/2016Visiting Scholar

The Department of Pharmacology and Chemical Biology,

University of Pittsburgh, Pittsburgh, PA

  

07/09/2014-02/23/2015Researcher Scientist

The Department of Obstetrics and Gynaecology,
The University of Hong Kong, Hong Kong

  

07/01/2007-09/30/2012Junior Lecturer & Lecturer

The Department of Public Health, The Chongqing Medical

University, Chongqing, China

RESEARCH INTEREST:

  

Reproductive Sciences: Embryo implantation; Placental development

  

PUBLICATIONS (# corresponding author):

  

1.Qian Feng, Zhuo-Ying Hu, Xue-Qing Liu, Xue Zhang, Xi Lan,Yan-Qing Geng, Xue-Mei Chen, Jun-Lin He, Ying-Xiong Wang, Yubin Ding#. The Stomatin-like protein 2 (Slp-2) is involved in endometrial stromal cell proliferation and differentiation during decidualization in mouse and human. Accepted by reproductive biomedicine online. 2016

2.Xue Zhang, Li-Juan Fu, Xue-Qing Liu, Zhuo-Ying Hu, Yu Jiang, Ru-Fei Gao, Qian Feng, Xi Lan, Yan-Qing Geng, Xue-Mei Chen, Jun-Lin He, Ying-Xiong Wang, Yu-Bin Ding# The NM23 regulates decidualization through PI3K-Akt-mTOR signaling pathways in mice and humans.Accepted by Human Reprod. 2016

3.Xi Lan, Li-Juan Fu, Zhuo-Ying Hu, Qian Feng, Xue-Qing Liu, Xue Zhang, Xue-Mei Chen, Jun-Lin He, Ying-Xiong Wang, Yu-Bin Ding#. Length of files to edit: Standard Methylated Oligonucleotide (MON) induced E-cadherin promoter hypermethylation and associated decreased expression contribute to the Motility and Invasion of Human Trophoblast.Accepted by Reprod Fertil Dev. 2016. DOI: 10.1071/RD16031

4.Wei Peng Ying Chen , Xin Luo , Nan ShanXi LanDavid OlsonHua ZhangYu-Bin Ding # and Hongbo Qi #. The aberrant methylation of MEST/PEG1 represses trophoblast invasion via downregulated Twist, N-cadherin and Vimentin expression- a possible pathological mechanism of missed abortion. Accepted by Placenta.

5.Wu PH, Chen XM, Liu XQ, He JL, Feng Q, Lan X, Zhang X, Geng YQ, Wang YX, Ding YB#. Activation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor gene expression following DNA demethylation in placental choriocarcinoma and transformed cell lines. Reprod Fertil Dev. 2015 May 27. doi: 10.1071/RD14408.

6.Xia YY, Ding YB, Liu XQ, Chen XM, Cheng SQ, Li LB, Ma MF, He JL #, Wang YX #. Racial/Ethnic Disparities in human DNA methylation. Accepted by Biochim Biophys Acta. 2014 Aug;1846(1):258-262.

7.Ding YB, He JL, Chen XM, Liu XQ #, Wang YX #. LongSAGE analysis of gene expression profile in mice endometrium during the window of implantation. Mol Biol Rep. 2013; 40(1):651-663.

8.Ding YB, Long CL, Liu XQ, Chen XM, Guo LR, Xia YY, He JL#, Wang YX#. 5-Aza-2′-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes. PLoS ONE. 2012; 7(9): e45364.

9.Long CL, He JL, Liu XQ, Chen XM, Gao RF, Wang YX, Ding YB #. Dietary folate deficiency in pseudopregnant mice has no effect on homeobox a10 promoter methylation or expression. Reproductive Sciences. 2012; 19(12): 1268-1275.

10.Ding YB, He JL, Liu XQ, Chen XM, Long CL, Wang YX. Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency. Reproduction. 2012; 144 (1): 91-100.

11.Gao RF, Liu XQ, Wang YX, Chen XM, Ding YB #, He JL #. The IGF2 expression in blood is not associated to its imprinting status in healthy pregnant Chinese women. Biological research. Biol Res 2012, 45(4): 351-356.

12.Gao RF, He JL, Liu XQ, Ding YB#, Chen XM, Chen Q, Tan Y, Wang YX#. Evaluation of IGF2 Imprinting Status and the Levels of Folate Biomarkers in the Second Trimester Pregnant Chinese Women. J Reprod Med. 2011; 56 (5-6): 254-260.

13.Xia YY, Ding YB, Liu XQ, Chen XM, Cheng SQ, Li LB, Ma MF, He JL, Wang YX. Allelic methylation status of CpG islands on chromosome 21q in patients with Trisomy 21. Mol Med Rep. 2014 May;9(5):1681-8.

14.Fu LJ, Ding YB, Wu LX, Wen CJ, Qu Q, Zhang X, Zhou HH. The Effects of Lycopene on the Methylation of the GSTP1 Promoter and Global Methylation in Prostatic Cancer Cell Lines PC3 and LNCaP. Int J Endocrinol. 2014;2014:620165. doi: 10.1155/2014/620165. Epub 2014 Oct 20.

15.Yin NL, Zhang H, Luo X, Ding YB, Xiao XQ, Liu XR, Shan N, Zhang XM, Deng QY, Zhuang BM, and Qi HB. IL-27 Activates Human Trophoblasts to Express IP-10 and IL-6: Implications in the Immunopathophysiology of Preeclampsia.2014 http://dx.doi. org/10.1155/2014/926875

16.Zhou Y, Zhang H, He J, Chen X, Ding Y, Wang Y, Liu X. Effects of sodium fluoride on reproductive function in female rats. Food Chem Toxicol. 2013,56:297-303.

17.Yang ZM, Bai B, Luo X, Xiao XQ, Liu XR, Ding YB,Zhang H, Gao L, Juan Li, Qi HB. Down-regulated Krüppel-like factor 8 is involved in decreased trophoblast invasion under hypoxia-reoxygenation condition. Reproductive sciences. 2014 Jan;21(1):72-81.

18.Zhou Y, Qiu Y, Zhang H, He J, Chen X, Ding Y, Wang Y, Liu X#. The toxicity mechanism of sodium fluoride on fertility in female rats. Food Chem Toxicol. 2013,62: 566-572.

19.Shen LJ, He JL, Yang DH, Ding YB, Chen XM, Geng YQ, Liu SJ, Liu XQ, Wang YX. Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus. Reprod Sci. 2013;20(12):1518-28.

20.Cheng SQ, Xia YY, He JL, Liu XQ, Chen XM, Ding YB, Wang YX, Peng B, Tu BJ. Neurotoxic effect of subacute benzo(a)pyrene exposure on gene and protein expression in Sprague-Dawley rats. Environ Toxicol Pharmacol. 2013;36(2):648-58.

21.Liu S, He J, Chen X, Ding Y, Geng Y, Wu M, Liu X, Wang Y. Costimulatory Molecule CD28 Participates in the Process of Embryo Implantation in Mice. Reprod Sci. 2013 Dec 13. [Epub ahead of print]

22.Liu X, Gao R, Chen X, Zhang H, Zheng A, Yang D, Ding Y, Wang Y, He J. Possible roles of mmu-miR-141 in the endometrium of mice in early pregnancy following embryo implantation. PLoS One. 2013 Jun 25;8(6):e67382.

23.Li R, He J, Chen X, Ding Y, Wang Y, Long C, Shen L, Liu X. Mmu-miR-193 Is Involved in Embryo Implantation in Mouse Uterus by Regulating GRB7 Gene Expression. Reprod Sci. 2013 Dec 13. [Epub ahead of print]

24.Gao RF, Ding YB, Liu XQ, Chen XM, Wang YX, Long CL, Li S, Guo LR, He JL#. Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cdh1 and Pgr, and its influence on endometrial receptivity and embryo implantation. Hum Reprod. 2012; 27(9): 2756-2765.

25.Li R, Yu C, Gao RF, Liu XQ, Lu J, Zhao LT, Chen XM, Ding YB, Wang YX, He JL#. Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice. J Hazard Mater. 2012; 241-242: 231–240.

26.Shao RY, Liu XQ, Ding YB, Chen XM, Gao RF, He JL#, Wang YX#. Characterization of IK cytokine expression in mouse endometrium during early pregnancy and its significance on implantation. Int J Mol Med. 2012; 30(3):615-621.

27.Wang YY, Xue J, Cheng SQ, Ding YB, He JL, Liu XQ, Chen XM, Wang YX, Feng XY and Xia YY. The relationship between manganism and the workplace environment in China. Inter J Env Res Pub Heal. 2012, DOI: 10.2478/s13382-012-0049-z.

28.Li S, Chen XM, Ding YB, Liu XQ, Wang YX, He JL#. Expression of translationally controlled tumor protein (TCTP) in the uterus of mice of early pregnancy and its possible significance during embryo implantation. Hum Reprod. 2011; 26(11): 2972-2980.

29.Huang P, Yu C, Liu XQ, Ding YB, Wang YX#, He JL#. Cytotoxicity of tubeimoside I in human choriocarcinoma JEG-3 cells by induction of cytochrome c release and apoptosis via the mitochondrial-related signaling pathway. Int J Mol Med. 2011; 28(4):579-587.

30.Chen XM, He JL, Ding YB, Liu XQ, and Wang YX #. The role of mTOR in mouse uterus during embryo implantation. Reproduction, 2009; 138(2): 351-356.

31.He JL, Liu XQ, Ding YB, Yu C, Weng YG, Chen XM, Gao RF, Wang YX#. An improved method for staining kinetochores of human chromosomes. Indian J Exp Biol. 2009; 47(5):376-378.

32.Cheng SQ, He JL, Dong YL, Liu XQ, Ding YB, Gao RF, Tan Y, Ye Q, Tian ZL, Wang YX#. Characterization of calreticulin expression in mouse endometrium during embryo implantation. Biol Res. 2009; 42(4):505-516.

CONFERENCE ABSTRACT

1.ACGA-HKSMG International Conference on Genetic and Genomic Medicine. Abstract title“serial analysis of gene expression (SAGE) analysis of differential gene expression during pre-implantation and implantation”. HongKong, China. 2008

2.The first summit of China-Canada-Newzealand-International Pregnancy Research Alliance (IPRA). Report title: Role of DNA methylation in placentation and pathogenesis of Preeclampsia. Chongqing, China. 2013

3.The 14thmeeting of Reproductive Biology Branch Society of Chinese Zoological Society. Report title: Role of DNA methyltransferases (Dnmt) in the mouse uterus during early pregnancy and susceptibility to 5-aza-dC and folate. Zhangjiajie, Hunan, China. 2013

  

RESEARCH GRANTS (PRINCIPAL INVESTIGATOR)

1.National Natural Science Foundation of China (No.81370731): Hypoxia/Reoxygenation leads to failure of DNA methylation co-regulated epithelial-mesenchymal transition in trophoblast-a potential mechanism of pathogenesis and progression in preeclampsia. 2013-2017

2.National Natural Science Foundation of China (No.30700898): DNA methylation controlling on extravillous trophoblast invasion.2007-2010

3.Excellent young scholars of Chongqing Medical University:

4.Chongqing Science & Technology Commission (No.cstc2011jjA10085): The role of epigenetic regulated TPD52 in trophoblast invasion.2011-2014

5.Chongqing Science & Technology Commission (No.CSTC2007BB5286): Functional role of epigenetic modification in extravillous trophoblast invasion. 2007-2009

6.Chongqing Municipal Education Commission (No. KJ130309): The role of DNA methylation regulated SF-1 expression in mouse decidualization. 2013-2015

7.Chongqing Municipal Education Commission (No. Kj090313): Dose folate affect embryo development by altering the imprinting of IGF2. 2009-2011

8.Institute for Population and Family Planning of Chongqing (No. 1201): Bisphenol A (BPA) effects ondifferentiation and biological function of trophoblast and embryo development .2012-2014

9.Institute for Population and Family Planning of Chongqing (No.0801): Epigenenetic regulation of abnormal invasion of trophoblast— lesson from hydatidiform moles. 2008-2010

10.Chongqing Family Planning Commission (No. 2007-1-002): Profile of folate metabolite and imprinting status of IGF2 in the human first trimester. 2007-2008

11.Chongqing Medical Univeristy for excellent doctoral thesis: DNA methylation regulation on invasive behavior of extravillous trophoblast 2010

12.Chongqing Medical Univeristy (No. xbyb200863): Folate deficiency impacts on DNA methylation pattern of genes involved in uterus reception in mouse. 2008-2009

13.Chongqing Medical Univeristy (No. nsflx200603): Mechanism of DNA methylation regulated in EVT invasion. 2007-2008

 

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