On May 16, 2025, Professor YANG Sheng's team at Chongqing Medical University published their latest research findings in Advanced Materials, titled "An Iron Balance Dual-Drive Strategy (IBDS) Promotes Bone Regeneration in Smokers by Regulating Mitochondrial Iron Homeostasis."
Smoking significantly disrupts the bone immune microenvironment, characterized by abnormal elevation of inflammatory factors and inhibition of osteogenic differentiation. This dual pathological feature renders traditional bone repair materials ineffective, becoming a major cause of failed dental implants and prolonged bone defects. Addressing smoking-related bone regeneration disorders has emerged as a critical challenge in oral medicine research.
To tackle this clinical issue, Prof. Yang's team revealed that cigarette smoke-induced disruption of mitochondrial iron homeostasis is the core mechanism triggering oxidative stress, ferroptosis, inhibition of osteogenic differentiation, and damage to the bone immune microenvironment.
This study achieved closed-loop innovation from mechanism elucidation and material design to functional validation, providing a novel solution for precise bone repair in high-risk populations such as smokers. It marks a breakthrough in the development of pathological microenvironment-responsive biomaterials.
The project was supported by the National Natural Science Foundation of China, the Chongqing Natural Science Foundation, and the Chongqing Medical University Future Medical Youth Innovation Team Support Program.
Full Article link:
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202501933
(Translated by AI)
