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National Clinical Research Center for Child Health and Disorders

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National Clinical Research Center for Child Health and Disorders is a National Clinical Research Center approved in 2019. It is one of the two National Clinical Research Centers for Child Health and Disorders in China. The Center belongs to the Children’s Hospital of Chongqing Medical University (CHCMU). CHCMU was established in 1956 by the Department of Pediatrics of Shanghai Medical College relocated in Chongqing. It is a comprehensive 3A pediatric hospital of medical care, research, and teaching. With the mission of "All for Children's Health", the Center is committed to scientific research in child health & disorders and pediatrics in China.

National Clinical Research Centers are co-funded by the Ministry of Science and Technology, National Health Commission, National Logistic Support Department and China Food and Drug Administration. For disease prevention and treatment in China, the centers are state-level science and technology innovation bases for technological innovation and achievement transformation, which are supported by collaborative network for clinical research, collaborative innovation, academic exchange, personnel training, achievement transformation and promotion of application.

The center has full support of the CHCMU. Prof. Li Qiu, CHCMU president, is the director of the Centre. The Center consists of an academic committee and a management committee, which respectively exercise the powers of decision-making and consultation on academic and managerial affairs. The Secretariat of the Center is the Scientific Research Management Office of CHCMU.

Children are the key group in Healthy China mission. Facing the needs of child health and disease prevention in China, the Center, based in the western China, serves people from the whole country. With "demand-oriented, strengthening advantages, highlighting features, joint construction and sharing, and collaborative development" as its development concepts and ideas as well as national needs as its mission, the Center conducts high-level clinical research, opens to innovation and international cooperation, and dedicates itself in helping the development of health industries in China by cooperating with hospitals, scientific research institutes and enterprises. Supported by the existed resources of pediatric medicine, the Center aims to co-establish a collaborative network for clinical resources and scientific cooperation, with the features of western China. . This will lay a solid foundation for the establishment of a clinical evaluation and transformation platform for new technologies in pediatric diagnosis and treatment. The Center will build a support system for the transformation of children's clinical research, carry out high-level clinical research, promote collaborative innovation, academic exchange, talent training, achievement transformation, promotion and application, realize the duties and tasks of the NCMRC to serve child health and the regional community.

Collaborative network construction: the first "Innovative Core Member Collaborations" has been established, covering 40 tertiary Children's Hospitals, Maternal and Child Health Hospitals and general hospitals with strong pediatrics in 29 provinces and cities across China. These hospital will work together and lead high-level pediatric clinical research, improve local research capacity and balance local medical resources in pediatrics.

Main research achievements: the Center has always been working to meet the national demands and published a number of high-impact academic papers in SCI journals in the fields of pathogenesis of respiratory viral infections, treatment of critical respiratory infections, construction of primary immunodeficiency disease prevention and treatment system, prevention and control of nutritional diseases and developmental behavioral disorders. The Center has also developed a number of new diagnostic and treatment technologies such as screening and molecular diagnosis of immune function, assessment of primary immunodeficiency disease, minimally invasive surgery, HIFU treatment of solid tumors in children. It has obtained more than 10 national medical technology qualifications.

Publicity and promotion of the achievements: the Center, based in the western China, is a national first-class medical research center in pediatrics. Supported by the collaborative network, the Center fully employs technologies such as the Internet and communication technology to carry out stable technical support, remote guidance, personnel training, expert consultation as well as the promotion and application of treatment guidelines and technical specifications. The Center actively promotes the construction of a national scientific base featuring child health and disorders and spreads healthcare knowledge to the public with the use of "Internet Plus" health management platform.

I. Key research fields

The four key fields of the Center’s basic and clinical research include Nutrition and Development, Infection and Immunity, Children Chronic Diseases Research and Prevention, and Congenital Malformations Correction Treatment.

II. Venue, equipment and facilities

The National Clinical Research Center for Child Health and Disorders consists of Clinical Big Data Platform, the GCP-compliant Drug Clinical Trials Platform, the Children’s Excellent Evidence and Guidelines Collaborative Innovation Laboratory and the Science Communication Base of Child Health and Disorders. The Clinical Big Data Platform has collected more than 30 million clinical samples which is beneficial to conducting clinical research and constructing a specialized disease databases. The Drug Clinical Trial Platform has established a  system for the management, safety and implementation of GCP, with multiple clinical trials for drugs, medical instruments and diagnostic reagents undertaken by professional groups from departments of pediatrics respiratory, hematology, neurology, nephrology, immunology, infectious diseases and otolaryngology. The Children’s Excellent Evidence and Guidelines Collaborative Innovation Laboratory was jointly established with the Evidence-Based Medicine Center of Lanzhou University to build a database of international standards for providing high-quality evidence-based guidelines and conducting better high-level clinical research. As a co-constructed base of “China Science Communication” proposed by Chinese Association for Science and Technology, the Center sticks to the idea "all for children's health" and dedicates itself to popularizing child health and disorders. The Science Communication Base of Child Health and Disorders has always been committed to the popularization of pediatrics. At the same time, Pediatric Research Institute has more than 7,500 m2 research and experiment rooms with research equipment worth more than 100 million yuan. Taking the Pediatric Research Institute as the basic platform of scientific research, the National Clinical Research Center has been striving for transformation and integration of basic and clinical research in pediatrics. 


III. Important Events

1. In November 2018, the Ministry of Science and Technology, the National Health Commission, the National Logistic Support Department and the National Medical Products Administration officially announced the results of the fourth batch of national clinical medical research centers.

2. In December 2018, CHCMU was approved to establish the University Engineering Research Center of Chongqing on Children’s Medical Big Data Intelligent Application of Chongqing Municipal Education Commission.

3. In May 2019, the Ministry of Science and Technology, the National Health Commission, the National Logistic Support Department and the National Medical Products Administration officially recognized the fourth batch of national clinical medical research centers. CHCMU was approved to establish a National Clinical Research Center for Child Health and Disorders.

4. In May 2019, CHCMU was approved to establish a high-level scientific research innovation platform-“Ministry of Education Key Laboratory of Child Development and Disorders” by Chongqing Municipal Education Commission.

5. In August 2019, the Children’s Hospital of Zhejiang University School of Medicine exchanged views with CHCMU on the establishment of the Center. The two sides discussed and established management system of the Center.

6. In November 2019, a plenary meeting of the first management committee of the National Clinical Research Center for Child Health and Disorders was held.

7. In December 2019, the commencement meeting of the establishment of the National Clinical Research Center for Child Health and Disorders was held.

8. In December 2019, the first meeting of the academic committee of the National Clinical Research Center for Child Health and Disorders was held.

9.  In December 2019, CHCMU was approved as a national first-class discipline site of pediatrics.

10. In January 2020, CHCMU was approved to be a “China Science Communication” co-construction base of the China Association for Science and Technology.

11. In September 2020, “the Children’s Excellent Evidence and Guidelines Collaborative Innovation Laboratory” of the National Clinical Research Center for Child Health and Disorders was jointly established with the Evidence-Based Medicine Center of Lanzhou University.

12.  In September 2020, the clinical research project guidelines discussion meeting of the National Clinical Research Center for Child Health and Disorders was held.

13.  In November 2020, the data sharing platform and the National Children’s Health and Disease Data Collection Platform (phone application) of the National Clinical Research Center for Child Health and Disorders were launched.

14. In December 2020, the Clinical Big Data Platform was built up and a test run was started.

15.  In February 2021, a plenary meeting of the management committee of the National Clinical Research Center for Child Health and Disorders was held.

16. In June 2021, the Center presented Collaborative Innovation Core Memberplagues to 40 members across 29 provinces and cities.

17.In December 2021, the Center was approved with a Major Project of the New Generation of Artificial Intelligence on the Sci-Tech Innovation 2030 Agenda, with funding amounting to 32.3 million yuan.

18.In December 2021, the Center was approved for 3 major research topics of Security of Reproductive, Women and Children Health, a national key research and development field in the Fourteenth Five-year Plan.

19.In December 2021, an Academic Committee meeting for the National Clinical Research Center for Child Health and Disorders was held.

20.In February 2022, the Center took lead in 2 multi-center clinical drug trial for the first time.

21.In March 2022, a plenary meeting of the 2022 Annual Management Committee of the National Clinical Research Center for Child Health and Diseases was held.

22.In March 2022, the Western Children's Cohort included 9 tertiary medical institutions in 5 provinces and municipalities including Chongqing, Sichuan, Gansu, Qinghai and Guizhou to build a platform  through joint efforts for sharing  Cohorts data and samples.

23.In March 2022, the Center launched the first Evidence-based Clinical Auxiliary Decision-making Platform for Children in China for trial run.

24.In April 2022, the center published a multi-center, randomized and controlled research results online on the application of three non-invasive ventilation modes in respiratory support after invasive mechanical ventilation for premature infants in AMA Pediatrics, the top journal in the field of pediatrics.

A Group Photo of the commencement Meeting of the Establishment of the National Clinical Research Center for Child Health and Disorders

The Academic Committee of the National Clinical Research Center for Child Health and Disorders 2019

The Academic Committee of the National Clinical Research Center for Child Health and Disorders 2021

The Management Committee of the National Clinical Research Center for Child Health and Disorders 2022

The Rendering of the National Clinical Research Center for Child Health and Disorders