Recently, under the joint guidance of Associate Professor Zang Guangchao from the Experimental Teaching Management Centre, and Associate Professor Zhang Yuchan from the Graduate School, a team of undergraduate students under Wu Hui (a five-year clinical medicine major in the class of 2018) and Meng Zexuan (a five-year clinical medicine major in the class of 2019) from the Second Clinical College of CQMU observed for the first time that lipopolysaccharide (LPS) inhibits the dynamic release of dopamine (DA) from dopaminergic neurons in a sub-second time scale. The research findings are published online in the journal “Biosensors and Bioelectronics” under the article title "Aptamer functionalized cell membrane for brain and nerve cell sensing with high sensitivity and stability".
In this study, the biomimetic neurochemical sensing interface was constructed by combining cell membrane camouflage and modification technology with the aptamer capture technology to realize the in-situ and long-term stable monitoring of DA in cells and living brain tissue, providing a new feasible tool for exploring neurochemical dynamics and pathophysiological mechanisms of brain diseases.
In recent years, the Experimental Teaching Management Centre and the Second Clinical College have continued to conduct in-depth cooperation under the framework of the "Excellent Medical Undergraduate Tutorial System Project" (EMTS), jointly promoting the cultivation of innovative talents. This accomplishment is another new achievement in the field of scientific research and innovation after the undergraduate team winning the national silver medal of the 8th China international "Internet Plus" Undergraduate Innovation and Entrepreneurship Competition in 2022.