Under the joint guidance of Associate Professor ZANG Guangchao of Experimental Teaching Management Centre of Chongqing Medical University, Prof. LI Chenzhong, Academician of the Canadian Academy of Engineering and Professor of the Chinese University of Hong Kong, and Professor WANG Guixue of Chongqing University, ZENG Zhongyuan, student from the First Clinical College with a specialty of Clinical Medicine (Batch 2019, five-year bachelor programme), and WANG Jian, master student from the College of Basic Medicine with a specialty of Pathology and Pathophysiology, have recently made progress in the research on the mechanism of ascorbic acid (AA) selectively killing tumor cells. The results were published in the journal ‘Advanced Science’ under the title of "Bioinspired Flexible Sensor for the Electrochemical Probing of Dynamic Redox Disequilibrium in Cancer Cells ".
Cancer is a serious threat to life and health, and Vitamin C (AA) may be a potential drug for its treatment. A large number of studies have shown that AA can selectively kill tumor cells, and has different therapeutic effects on different types of tumors. However, the mechanism by which AA selectively kills tumor cells and the source of differential killing effects remains unclear.
This study provides a reliable subsecond kinetic monitoring tool to dissect the molecular mechanism of cellular oxidative stress. At the same time, it also provides new insights into the mechanism of selective killing of tumor cells by AA and provides guidance for its clinical application. This research was supported by the National Natural Science Foundation of China, Jinfeng Laboratory Foundation, Chongqing Natural Science Foundation, and the Excellent Medical Undergraduate Tutorial System (EMTS) of CQMU.