Events & News


    Prof. TANG Yong's Team at the College of Basic Medicine of CQMU Unveils New Antidepressant Mechanism of Exercise


    On February 15th, 2024, Professor TANG Yong's team from the College of Basic Medicine at Chongqing Medical University (CQMU) published a research article online in Molecular Psychiatry, which is a prestigious international journal on mental disorders. The article, titled "Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress," sheds light on a new mechanism by which running exerts antidepressant effects through the reduction of neuroinflammation.

    Depression is a serious neuropsychiatric disorder. Running can effectively alleviate symptoms of depression, however the underlying mechanism still requires clarification. Microglia, innate immune cells in the central nervous system, play a crucial role in the pathogenesis of depression through an imbalance in M1/M2 polarization and the resulting dysregulation of neuroinflammation. The study revealed that running significantly decreased the quantity of microglia and enhanced their morphology in the hippocampus, as well as rebalanced M1/M2 polarization, which in turn alleviated depression-like behaviors in mice subjected to chronic unpredictable stress (CUS). The findings indicate that running exercise may modulate the balance between M1/M2 polarization and suppress neuroinflammation in the hippocampus of CUS mice, potentially through the activation of the adiponectin/AdipoR1 signaling pathway.

    This research investigated the antidepressant effects of running by examining the connection between the peripheral and central nervous systems, offering a significant scientific foundation for identifying novel targets and approaches for preventing and treating depression.

    Link to full article: