PERSONAL INFORMATION
Name: Zhang Zheng
Gender: Female
Title: Professor
Position: PI
CONTACT INFORMATION
Email: zhangzheng@cqmu.edu.cn
Address: 1 Yixueyuan Road, Yuzhong District,
Chongqing 400016, P.R.China
Phone: +86-68485868
EDUCATION EXPERIENCE
1995.9-2000.7: B.S., Clinical Medicine, Southwest Medical University
2000.9-2003.7:M.D.,Anatomy&histology embryology,Chongqing Medical University
2006.9-2009.7: Ph.D, Biomedical Engineering, Chongqing Medical University
WORKING EXPERIENCE
2003.7-2005.9: Assistant, Chongqing Medical University
2005.9-2010.9: Instructor, Chongqing Medical University
2010.9-2016.9: Associate Professor, Chongqing Medical University
2016.9-present: Professor, Chongqing Medical University
2011.7-2021.8: Visiting Scholar, Harvard Medical School, Boston, MA.
RESEARCH INTERESTS
Research in our lab aims at understanding the genetic pathways for the prevention and treatment of acute kidney injury and diabetic kidney disease. In particular, we are interested in the transcriptional and post-transcriptional control. We identified and investigated transcription factors and non-coding RNA that control cell proliferation, inflammation and fibrosis as well as related human kidney diseases, such as acute kidney injury and diabetic kidney disease. We apply a variety of molecular, cellular, and genetic approaches and we have made significant contribution to our understanding of the molecular mechanisms controlling kidney gene expression during occurrence and development of kidney diseases. We have undertaken 3 state projects in science and technology and 5 projects of National Natural Science Foundations of China.
In addition to actively participate teaching of graduate students in the School of Basic Medicine, I have mentored undergraduate students, graduate students and young researchers in the past 20 years.
HONOUR & AWARDS
2019, Academic and Technical Leader Reserve Candidate of Chongqing
2022, Outstanding Undergraduate Thesis Supervisor of Chongqing
PUBLICATIONS
1. Zhang Z*. LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy. Cell Death Dis. 2017, 8(2):2583.
2. Zhang Z*. LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling. Cell Death Dis. 2018, 9(5):461.
3. Zhang Z*. Long non-coding RNA Rpph1 promotes the inflammation and mesangial cell proliferation via interacting with Gal-3 in diabetic nephropathy. Cell Death Dis. 2019,10(7):526-532.
4. Zhang Z*. The topological key lncRNA H2k2 from ceRNA network promotes mesangial cell proliferation via miR-449a/b/Trim11/Mek signaling pathway in diabetic nephropathy. FASEB J. 2019,33(10):11492-11506.
5. Zhang Z*. CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease. Front Immunol. 2023 Sep 6;14.
