PERSONAL INFORMATION
Name: Li Zhang
Gender: Male
Title: Professor
Position: Director of Laboratory of Stem cell and Tissue Engineering
CONTACT INFORMATION
E-mail: zhangli@cqmu.edu.cn
Address: Department of Pathophysiology, Chongqing Medical Unversity, 1 Yixueyuan Road,
Chongqing, 400016, China.
Phone: +86-68485626
EDUCATION EXPERIENCE
2002.09-2007.07 PhD.
Pathophysiology
Tongji Medical College, Huazhong University of Science and Technology, China
1997.09-2002.07 MD.
Clinical Medicine
Tongji Medical College, Huazhong University of Science and Technology, China
WORKING EXPERIENCE
2014.09- Professor
Department of Pathophysiology, Chongqing Medical University, China
2009.11-2014.09 Associate professor
Department of Pathophysiology, Chongqing Medical University, China
2007.07-2009.10 Lecturer
Department of Pathophysiology, Chongqing Medical University, China
RESEARCH INTERESTS
1. The molecular mechanisms of inflammatory injury, including the metabolic reprogramming in inflammation.
2. Metabolism-associated molecular targets for anti-inflammatory drug discovery.
PUBLICATIONS (*corresponding author)
1. Kerui Fan, Kun Chen, Xinyan Zan, Ying Zhi, Xue Zhang, Xinyue Zhang, Jinghuan Qiu, Gang Liu, Longjiang Li, Li Tang, Kai Hu, Jingyuan Wan, Xianqiong Gong, Yongqiang Yang*, Li Zhang*. Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury. Cell Death & Disease. 2023, 14: 486
2. Shuang Zhao, Yili Sun, Xicheng Wu1, Yongqiang Yang, Kerui Fan, Kai Hu, Yasha Qin, Kexin Li, Ling Lin, Kun Chen, Yuhua Ma, Min Zhu, Gang Liu*, Li Zhang*, Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2. Front. Pharmacol. 2023, 14:1092943.
3. Xue Zhan1, Ying Zh1, Xinyan Za1, Kerui Fan, Kun Chen, Shuang Zhao, Xinyi Dai, Longjiang Li, Yongqiang Yang, Kai Hu, Xianqiong Gong*, Li Zhang*. Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression. Biochim Biophys Acta Mol Basis Dis. 2023, 1869 (4): 166656
4. Xinyan Zan, Kerui Fan, Kun Chen, Ying Zhi, Longjiang Li, Yongqiang Yang, Kai Hu, Ling Lin, Li Tang, Gang Liu*, Li Zhang*. Activation of GPR81 Aggravates Remote Organ Injury During Hepatic Ischemia-Reperfusion Injury. Transplantation Proceedings. 2022, 54(7):1992-1997
5. Kerui Fan, Xinyan Zan, YingZhi, Yongqiang Yang, Kai Hu, Xinyue Zhang, Xue Zhang, Shuang Zhao, Kun Chen, Xianqiong Gong, Rui Tian*, Li Zhang*. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice. Biochemical and Biophysical Research Communications. 2022, 607: 103-109
6. Ruyue Shao, Yongqiang Yang, Kerui Fan, Xicheng Wu, Bowen Xin, Rong Jiang, Li Tang, Longjiang Li, Yi Shen, Gang Liu*, Li Zhang*. REV-ERBα Agonist GSK4112 Attenuates Fas-induced Acute Hepatic Damage in Mice. Int. J. Med. Sci. 2021, 18(16): 3831-3838.
7. Kai Hu, Lidan Xiao, Longjiang Li, Yi Shen, Yongqiang Yang, Jiayi Huang, Yaping Wang, Li Zhang, Sha Wen*, Li Tang*. The mitochondria-targeting antioxidant MitoQ alleviated Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice. Immunology Letters. 2021, 240: 24-30
8. Dan Zhou, Feng Yang, Ling Lin, Li Tang, Longjiang Li, Yongqiang Yang, Dingrong Liu, Chong Zhang, Tong Wu, Huijie Wei, Xiaoming Zhang*, Li Zhang*. The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice. Exp Anim. 2021, 70(3): 302-310.
9. Xiaohui Lv, Honghong Zhou, Kai Hu, Ling Lin, Yongqiang Yang, Longjiang Li, Li Tang, Jiayi Huang, Yi Shen, Rong Jiang, Jingyuan Wan*, Li Zhang*. Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1. Pharmacological Research. 2021,172:105838
10. Xianwen Peng, Yongqiang Yang, Li Tang, Jingyuan Wan, Jie Dai, Longjiang Li, Jiayi Huang, Yi Shen, Ling Lin, Xianqiong Gong, Li Zhang*. Therapeutic benefits of apocynin in mice with lipopolysaccharide/D-galactosamine-induced acute liver injury via suppression of the late stage proapoptotic AMPK/JNK pathway. Biomedicine & Pharmacotherapy. 2020, 125: 110020
11. Yisheng Luo, Yongqiang Yang, Yi Shen, Longjiang Li, Jiayi Huang, Li Tang, Li Zhang*. Luzindole attenuates lipopolysaccharide/D-galactosamine-induced acute hepatitis in mice. Innate Immun. 2020, 26(4):319-327
12. Wenze Xiao, Li Zhang*. Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice. Chin Med J (Engl). 2019, 132(20):2438-2445
13. Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang*. The succinate dehydrogenase inhibitor dimethyl malonate alleviates lipopolysaccharide/D-galactosamine-induced acute hepatic damage in mice. Innate Immun. 2019, 25(8): 522-529
14. Yongqiang Yang, Ruyue Shao, Rong Jiang, Min Zhu, Li Tang, Longjiang Li, Li Zhang*. β-hydroxybutyrate exacerbates lipopolysaccharide/D-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice. J Biochem Mol Toxicol. 2019, 33(9):e22372
15. Kerui Fan, Ling Lin, Qing Ai, Jingyuan Wan, Jie Dai, Gang Liu, Li Tang, Yongqiang Yang, Pu Ge, Rong Jiang, Li Zhang*. Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy. Front. Immunol. 2018, 9: 1464
16. Honghong Zhou, Li Tang, Yongqiang Yang, Ling Lin, Jie Dai, Pu Ge, Qing Ai, Rong Jiang, Li Zhang*. Dopamine alleviated acute liver injury induced by lipopolysaccharide/d-galactosamine in mice. International Immunopharmacology. 2018, 61: 249–255
17. Kejia Wu, Rui Tian, Jing Huang, Yongqiang Yang, Jie Dai, Rong Jiang, Li Zhang*. Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. Chem Biol Interact. 2018, 291: 1-6
18. Kai Hu, Yongqiang Yang, Ling Lin1, Qing Ai, Jie Dai, Kerui Fan, Pu Ge, Rong Jiang, Jingyuan Wan, Li Zhang*. Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway. Front Immunol. 2018, 9: 426
19. Pu Ge, Xin Yao, Jing Li, Rong Jiang, Jie Dai, Li Zhang*. Diminazene aceturate alleviated lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice. Biomedicine & Pharmacotherapy. 2018, 98: 142-148
20. Jing Huang, Rui Tian, Yongqiang Yang, Rongjiang, Jie Dai, Li Tang*, Li Zhang*. The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia. Innate Immunity. 2017, 23(8):678-686
21. Changming Yang, Jun Yi, Xianqiong Gong1, Pu Ge, Jie Dai, Ling Lin, Yu Xing, Li Zhang*. Anti-oxidative and anti-inflammatory benefits of the ribonucleoside analogue 5-azacitidine in mice with acetaminophen-induced toxic hepatitis. International Immunopharmacology. 2017, 48: 91-95
22. Kerui Fan1, Kejia Wu1, Ling Lin1, Pu Ge, Jie Dai, Xiaojiao He, Kai Hu, Li Zhang*. Metformin mitigates carbon tetrachloride-induced TGF-β1/Smad3 signaling and liver fibrosis in mice. Biomedicine & Pharmacotherapy. 2017, 90: 421-426
23. Kai Hu, Xianqiong Gong, Qing Ai, Ling Lin, Jie Dai, Lu Cai, Rong Jiang, Pu Ge, Li Zhang*. Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis. Cell Death and Disease. 2017, 8(3): e2637
24. Dan Zhou, Qing Ai, Ling Lin, Xianqiong Gong, Pu Ge, Qian Che, Jingyuan Wan, Aiqing Wen, Li Zhang*. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside attenuates Lipopolysaccharide/D-galactosamine-induced acute hepatitis in mice. Innate Immunity. 2015, 21(7): 698-705. IF: 3.271
25. Lu Cai, Kai Hu, Ling Lin, Qing Ai, Pu Ge, Yiqing Liu, Jie Dai, Bin Ye, Li Zhang*. AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury. Biochem Biophys Res Commun. 2015, 465(3): 381-386
26. Yuping Jing, Kunwei Wu, Jiashuo Liu, Qing Ai, Pu Ge, Jie Dai, Rong Jiang, Dan Zhou, Qian Che, Jingyuan Wan, Li Zhang*. Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation. PLoS One. 2015, 10(4): e0122781.
27. Qian Che, Ling Lin, Qing Ai, Pu Ge, Jie Dai, Rong Jiang, Dan Zhou, Jingyuan Wan, Li Zhang*. Caloric restriction mimetic 2-deoxyglucose alleviated lethal liver injury induced by Lipopolysaccharide/D-galactosamine in mice. Biochemical and Biophysical Research Communications. 2015, 459(3):541-546.
28. Changming Yang, Xianqiong Gong, Qing Ai, Pu Ge, Ling Lin, Li Zhang*. 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside alleviated Carbon Tetrachloride-induced acute hepatitis in mice. International Immunopharmacology. 2015, 25(2): 393-399.
29. Mengying Jia, Yuping Jing, Qing Ai, Rong Jiang, Jingyuan Wan, Ling Lin, Dan Zhou, Qian Che, Longjiang Li, Li Tang, Yi Shen, Li Zhang*. Potential role of catalase in mice with Lipopolysaccharide/D-galactosamine-induced fulminant liver injury. Hepatology Research. 2014, 44(11):1151-1158.
30. Qing Ai, Yuping Jing, Rong Jiang, Ling Lin, Jie Dai, Qian Che, Dan Zhou, Mengying Jia, Jingyuan Wan, Li Zhang*. Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates Lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice. International Immunopharmacology. 2014, 21(1): 200-207.
31. Jie Dai, Mingwei Liu, Qing Ai, Ling Lin, Kunwei Wu, Xinyu Deng, Yuping Jing, Mengying Jia, Jingyuan Wan, Li Zhang*. Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. Chemico-Biological Interactions. 2014, 216: 34-42.
32. Yuping Jing, Qing Ai, Ling Lin, Jie Dai, Mengying Jia, Dan Zhou, Qian Che, Jingyuan Wan, Rong Jiang, Li Zhang*. Protective effects of Garcinol in mice with Lipopolysaccharide/D-galactosamine-induced apoptotic liver injury. International Immunopharmacology. 2014, 19(2): 373-380.
33. Jingyuan Wan, Xia Gong, Rong Jiang, Zhuo Zhang, Li Zhang*. Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1. Phytotherapy Research. 2013, 27(8):1136-42.
34. Jun Xie, Jingyuan Wan, Rong Jiang, Hongxu Lu, Xiaorong Peng, Li Zhang*. Up-regulation of Sirt1 in carbon tetrachloride-induced acute liver injury. Drug and Chemical Toxicology. 2013, 36(3):277-83
35. Jun Xie, Xiaoming Zhang, Li Zhang*. Negative regulation of inflammation by SIRT1. Pharmacological Research. 2013, 67(1): 60-67
36. Hongxu Lu, Jingyuan Wan, Rong Jiang, Jun Xie, Xiaorong Peng, Li Zhang*. Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice. Toxicology Mechanisms and Methods. 2012, 22(8):648-655.
37. Xinyu Deng, Kunwei Wu, Jingyuan Wan, Longjiang Li, Rong Jiang, Mengying Jia, Yuping Jing, Li Zhang*. Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. Food and Chemical Toxicology. 2012, 50(9): 3073-3078
