PERSONAL INFORMATION
Name: Yu Shanshan
Gender: Female
Title: Dr.
Position: Pathologist and Associate Professor,
Department of Pathology, Chongqing Medical University,
Chongqing, China
CONTACT INFORMATION
Email: yushanshan2014@cqmu.edu.cn
Address: Chongqing Medical University, Yixueyuan Road 1, 400016 Chongqing, China
Phone: +86-023-68485789
EDUCATION EXPERIENCE
2012, PhD. Tissue Engineering and Cell Engineering, Chongqing Medical University, Chongqing, China
2007, BM, Clinical Medicine, Chongqing Medical University, Chongqing, China
WORKING EXPERIENCE
2016- present
Pathologist and Associate Professor, Department of Pathology, Chongqing Medical University, Chongqing, China
2012-2016
Pathologist and Lecturer, Department of Pathology, Chongqing Medical University, Chongqing, China
RESEARCH INTERESTS
1. I arrange the program of “Effect and mechanism of Phospholipase A2 of peroxiredoxin 6 in cerebral ischemia/reperfusion injury ”. This work was supported by the National Natural Science Foundation of Chongqing (No. cstc2016jcyA0135).
2. I have arranged the program of “Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury ”. This work was supported by the Natural Science Foundation of the Chongqing Education Committee, China (No. KJ1500230).
I have arranged the program of “Regulation mechanism of GSK-3 in Nrf2 transcription activity on cerebral ischemia/reperfusion ”. This work was supported by the National Natural Science Youth Foundation of China (No.81301125)
HONOUR & AWARDS
2015 The Third Prize of Teaching Competition , Chongqing Medical University.
2014 The Second Prize of Teaching Competition , School of Preclinical Medicine, Chongqing Medical University.
2012 Excellent Doctor Degree Paper, Chongqing Medical University.
PUBLICATIONS
(1) Wang C#, Peng L, Wang Y, Xue Y, Chen T, Ji Y, Li Y, Zhao Y*, Yu S* . Integrative Analysis of Single-Cell and Bulk Sequencing Data Depicting the Expression and Function of P2ry12 in Microglia Post Ischemia-Reperfusion Injury. Int J Mol Sci. 2023 5;24(7):6772.
(2) ZhaoN#, Li Y#, Wang C, Xue Y, Peng L, Wang T, Zhao Y, Xu G, Yushanshan* . DJ-1 activatesthe Atg5 -Atg12- Atg16L1 complex via Sirt1 to influence microglial polarization and alleviate cerebral ischemia/ reperfusion-induced inflammatory injury . Neurochemistry International, 2022, 157: 105341.
(3) Wang T#, Xue Y# ,Li Y, Peng L, Zhao Y, Yushanshan* . DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways.Neuroscience, 2022, 504: 33-46.
(4) Zheng X#, Yu Shanshan#, Long J, Wei Q, Liu L, Liu C, Ren W . Comparison of the clinical characteristics of primary thyroid lymphoma and diffuse sclerosing variant of papillary thyroid carcinoma . Endocrine Connections, 2022 , 27;11(1):e210364
(5) Zhao N# , Wang T# , Peng L , Li Y, Zhao Y, Yushanshan* . Attenuation of Inflammation by DJ-1 May Be a Drug Target for Cerebral Ischemia-Reperfusion Injury. Neurochemical Research, 2021, 46(6):1470-1479.
(6) Peng L#, Zhou Y , Jiang N, Wang T, Zhu J, Chen Y, Li L , Zhang J, Yushanshan *, ZhaoY*. DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke. Journal of Neuroinflammation. 2020 , 17(1):81.
(7) Wang T# , Zhao N , Peng L, Li Y, Huang X,Zhu J,Chen Y, Yushanshan *, ZhaoY*. DJ-1 Regulates Microglial Polarization Through P62-Mediated TRAF6/IRF5 Signaling in Cerebral Ischemia-Reperfusion. Frontiers in Cell and Developmental Biology, 2020, 8.
(8) Peng L#, Zhao Y , Li Y , Zhou Y, Li L ,Lei S, Yushanshan*, Zhao Y*. Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury. Journal of Molecular Medicine, 2019, 97:189-199.
(9) Yu Shanshan#, Jiang B , Tan L, Gao M, Lei S, Peng L, Zhao Y*. Phospholipase A2 of peroxiredoxin 6 plays a critical role in cerebral ischemia/reperfusion inflammatory injury. Frontiers in Cellular Neuroscience, 2017, 11:99.
(10) Chen X#, Liu Y#, Zhu J, Lei S, Dong Y, Li L, Jiang B, Tan L, Wu J, Yu Shanshan *, Zhao Y*. GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion. Scientific Reports,2016, 6:20196.
(11) Li Y#, Zhu J#, Liu Y , Chen X, Lei S, Li L, Jiang B, Tan L, Yu Shanshan*, Zhao Y*. Glycogen synthase kinase-3β Influences Injury Following Cerebral Ischemia / Reperfusion through Regulation of Nrf2 in Rats. International Journal of Biological Sciences, 2016，12(5):518-531.
(12) Yu Shanshan#, Wang X, Lei S, Chen X, Liu Y, Zhou Y, Zhou Y, Wu J, Zhao Y*. Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage. Neurochemistry International, 2015, 82C:19-27.
(13) 喻姗姗#；刘远玲；陈曦;；周云川；周杨；巫静娴；赵涌*.Sulfiredoxin-1对大鼠星形胶质细胞缺血损伤的保护作用.第三军医大学学报, 2015, 37(01):11-15.
(14) Yu Shanshan#, Zhao J, Wang X, Lei S, Wu X, Chen Y, Wu J, Zhao Y*. 4-hydroxybenzyl alcohol induces neuroprotection through up-regulation of antioxidant protein expression via the PI3K/Akt pathway, Neurochemical Research, 2013 , 38(7):1501-1516.
(15) Li Q#, Yu Shanshan#, Wu J, Zou Y, Zhao Y *.. Sulfiredoxin-1 protects PC12 cells against oxidative stress induced by hydrogen peroxide. Journal of Neuroscience Research. 2013, 91:861–870.
(16) Yu Shanshan#, Zhao J#, Lei SP, Lin XM, Wang LL, Zhao Y*. 4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. Neurochemical Research, 2011, 36(2):339-346.
(17) Yu Shanshan# Zhao J, Zheng WP, Zhao Y*. Neuroprotective effect of 4-hydroxybenzyl alcohol against transient focal cerebral ischemia via anti-apoptosis in rats. Brain Research, 2010, 1308 :167-175.
CONFERENCE
（1）Wang C , Zhu J , Peng L, Liu Y, Zhao Y, Cao Y, Yu Shanshan. Comparative analysis of polyclonal TRPS1 and moncolnal TRPS1 in multiple organs: Do only mamary epithelium express TRPS1? United States & Canadian Academy of Pathology Annual Meeting （USCAP 112th Annual Meeting) , March 11-16, 2023, in New Orleans, Louisiana, Poster.
（2）Yu Shanshan, Zhao Y, Zhao J, Chen Y, Li L. 4-hydroxybenzyl alcohol ameliorates cerebral ischaemic injury by suppression of oxidative stress and inflammation. Journal of Neurology, 2012；259：S79. 22nd Meeting of the European Neurological Society, June 09-12, 2012, Prague, Czech Republic, Poster.
