PERSONAL INFORMATION
Name: Sheng-yong Yang
Gender: Male
Title: Professor
CONTACT INFORMATION
Email: yangshengyong@cqmu.edu.cn
Address: Yixueyuan Road 1#, Yuzhong Dist.
Chongqing 400016, China
Phone: +86-23-68485991
EDUCATION EXPERIENCE
Jan 2012 – Jun 2014
Postdoc. University of Pittsburgh School of Medicine, Department of Surgery. Pittsburgh, PA, USA
Jun 2009 – Dec 2011
Postdoc. University of Pittsburgh School of Medicine, Department of Medicine. Division of Hematology/Oncology. Pittsburgh, PA, USA
Aug 2004 – Aug 2008
Biochemistry and Molecular Biology, PhD, Department of Biochemistry and
Molecular Biology, Peking University Health Science Center, Beijing, China.
Aug 1998 - Jul2001
Biochemistry and Molecular Biology, Master, Lanzhou University, Lanzhou, China.
Aug 1987 – Jul 1992
Bachelor of Medicine, Ningxia Medical University. Yinchuan, China.
WORKING EXPERIENCE
Nov 2014 - present
Department of biochemistry and molecular biology/Molecular medicine and cancer center, Chongqing medical university, Chongqing, China
Jul 2001 – Jul 2004
Department of biochemistry and molecular biology, Chongqing medical university, Chongqing, China
RESEARCH INTERESTS
Cancer biology and RNA editing, Anti-tumor drugs
HONOUR & AWARDS
An active member of Elsevier Advisory Panel
PUBLICATIONS
1. Li, Yi, Ning-Xi Wang, Chuan Yin, Shan-Shan Jiang, Jia-Chu Li, and Sheng-Yong Yang. 2022. "RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis" International Journal of Molecular Sciences 23, no. 17: 9656. https://doi.org/10.3390/ijms23179656
2. Xiao-Yu Chen*, Sheng-Yong Yang* , Xiao-Jie Ruan2,Hong-Yue Ding, Ning-Xi Wang, Fang Liu, Jia-Chu Li,and Yi LI. MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3β/β-catenin Signaling Axis. Cell Transplant. 2021 (accepted); DOI: 10.1177/09636897211053203.
3. Hong-Yue Ding, Wan-Yong Yang, Li-Hong Zhang, Li Li , Feng Xie , Hua-Yi Li, Xiao-Yu Chen , Zeng Tu , Yi Li, Yong Chen , and Sheng-Yong Yang. 8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway. Cell Transplant. 2020 Jan-Dec; 29:963689720958656. doi: 10.1177/0963689720958656.
4. Sheng-Yong Yang, Yi Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia, Shu-Yan Li. DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299 Cells Determines Sensitivity to 8-Chloro-Adenosine. International Journal of Molecular Sciences. 2018 May 28;19(6). pii: E1587. doi: 10.3390/ijms19061587
5. Guoliang Wang, Hui Wang, Sucha Singh, Pei Zhou, Shengyong Yang, Yujuan Wang, Zhaowei Zhu, Jinxiang Zhang, Alex Chen, Timothy Billiar, Satdarshan P. Monga, Qingde Wang. ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes. American Journal of Pathology.2015 Dec;185(12):3224-37. doi: 10.1016/j.ajpath.2015.08.002.Epub 2015 Oct 9.
6.Shengyong Yang, Peng Deng , Zhaowei Zhu , Jianzhong Zhu , Guoliang Wang , Liyong Zhang , Alex F Chen , Saumendra N Sarkar , Timothy R Billiar , Qingde Wang. Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs. The journal of immunology. 2014 Oct 1;193 (7):3436-3445
7. Huiling Cao, Ke Zhu, Lugui Qiu, Shuai Li, Hanjie Niu, Mu Hao, Shengyong Yang, Zhongfang Zhao, Yumei Lai, Judith L. Anderson, Jie Fan, Hee-Jeong Im, Di Chen, G. David Roodman and Guozhi Xiao. Critical Role of AKT Protein in Myeloma-induced Osteoclast Formation and Osteolysis. The Journal of Biological Chemistry. 2013, 288:30399-30410.
8. Guozhi Xiao, Hongqiang Cheng, Huiling Cao, Ka Chen, Yizeng Tu, Shibing Yu, Hongli Jiao, Shengyong Yang, Hee-Jeong Im, Di Chen, Ju Chen, and Chuanyue Wu. Critical Role of Filamin-binding LIM Protein 1 (FBLP-1)/Migfilin in Regulation of Bone Remodeling. The Journal of Biological Chemistry. 2012, 287:21450-21460.
9. Shengyong Yang, Haiyan Xu, Shibing Yu, Huiling Cao, Jie Fan, Chunxi Ge, Renny T. Fransceschi, Henry H. Dong, Guozhi Xiao. Foxo1 Mediates IGF1/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in osteoblasts. The Journal of Biological Chemistry. 2011, 286:19149-19158.
10. Zhidan Wu,Ping Jiao,Xueming Huang Bin Feng, Yajun Feng, Shengyong Yang, Phillip Hwang, Jing Du,Yaohui Nie, Guozhi Xiao, and Haiyan Xu. MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. The Journal of Clinical Investigation 2010, 120 (11): 3901-3911.
11. Sheng-Yong Yang, Xiu-Zhen Jia, Li-Yan Feng, Shu-Yan Li, Guo-Shun An,Ju-Hua Ni and Hong-ti Jia. Inhibition of Topoisomerase II by 8-Chloro-Adenosine Triphosphate Induces DNA Double-Stranded Breaks in 8-Chloro-Adenosine-Exposed Human Myelocytic Leukemia Cells. Biochemical Pharmacology. 2009 Feb 1;77(3):433-43.
12. Xiu-Zhen Jia*, Sheng-Yong Yang*, Jing Zhou, Shu-Yan Li, Ju-Hua Ni, Guo-Shun An, and Hong-ti Jia. Inhibition of CHK1 Kinase by Gö6976 Converts 8-Chloro-Adenosine-Induced G2/M Arrest into S Arrest in Human Myelocytic Leukemia K562 Cells. Biochemical Pharmacology. 2009 Mar; 77(5): 770-80.
13. Hai-Jun Zhang, Wen-Juan Li, Sheng-Yong Yang, Shu-Yan Li, Ju-Hua Ni, Hong-Ti Jia. 8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1sites. Journal of cellular biochemistry. 2009 Feb; 106(3): 464-72.
