PERSONAL INFORMATION
Name: Xiang Yunlong
Gender: Male
Title: Professor
Position: School of Basic Medical Sciences
CONTACT INFORMATION
Email: xiangyunlong1987@163.com
EDUCATION EXPERIENCE
l School of Life Sciences, Tsinghua University 2014.09-2019.07
Ph.D. in Epigenetics
l School of Life Sciences, Southwest University 2003.09-2007.07
B.S. in Bioengineering
WORKING EXPERIENCE
l School of Basic Medical Sciences, Chongqing Medical University 2020.01-present
Professor
l Institute of Zoology, Chinese Academic of Sciences 2011.02-2014.05
Research Assistant
l Third Military Medical University 2007.09-2010.12
Technician
RESEARCH INTERESTS
My current research interest is to investigate the dynamics of histone modification, DNA methylation, chromatin accessibility and 3D chromatin architecture during mouse oogenesis and early embryonic development. Using ultra-low-input chromatin analysis methods, my goal is to address the following fundamental questions pertinent to mammalian development: 1) How epigenetic modifications are programmed during oogenesis; 2) How does chromatin landscape reconfigure during mouse early lineage specification; 3) Deciphering epigenetic regulation in human early embryonic development and tumorigenesis.
SELECTED PUBLICATIONS
1. Wang XX#, Xiang YL#, Yu Y#, Wang R, Zhang Y, Xu QH, Sun H, Zhao ZA, Jiang XX, Wang XQ, Lu XK, Qin DD, Quan YJ, Zhang JQ, Shyh-Chang Ng, Wang HM, Jing NH, Xie W*, Li L*. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research 31(526–541). 2021. (# Equal contribution, * Corresponding author)
2. Xiang YL#, Zhang Y#, Xu QH, Zhou C, Liu BF, Du ZH, Zhang K, Zhang BJ, Wang XX, Gayen S, Liu L, Wang Y, Li YY, Wang QJ, Kalantry S, Li L, Xie W*. Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nature Genetics 52 (95-105). 2020.
3. Xu QH#, Xiang YL#, Wang QJ#, Wang LY#, Amour J.B., Bogutz A.B., Zhang Y, Zhang BJ, Yu G, Xia WK, Du ZH, Huang CY, Ma J, Zheng H, Li YY, Liu C, Walker C. L., Jonasch E, Lefebvre L, Wu M, Lorincz M, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nature Genetics 51 (844-856). 2019.
4. Zhang Y#, Xiang YL#, Yin QZ#, Du ZH#, Peng X, Wang QJ, Fidalgo M, Xia WK, Li YY, Zhao ZA, Zhang WH, Ma J, Xu F, Wang JL, Li L, Xie W*. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nature Genetics 51 (96-105). 2018.
