PERSONAL INFORMATION
Name: Xiangmei Wu
Gender: Female
Position: Associate professor, Chongqing Medical Univercity
CONTACT INFORMATION
Email: xmwu@cqmu.edu.cn
Address: Molecular Medicine and Cancer Research Center, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District Chongqing 400016 P. R. China
EDUCATION EXPERIENCE
09/2007 – 07/2010
Ph.D. in Clinical and Experimental Diagnostics
Dissertation: Silencing BMI-1 gene by RNAi affect biological characteristics and doxorubicin sensitivity of MCF-7 cell Chongqing Medical University
Advisor: Prof. Fang-zhou Song
09/2005 – 07/2007
Master in Molecular Biology
Research subject: The relativity between telomerase activity and acute leukemia Chongqing Medical University
Advisor: Prof. Fang-zhou Song
09/1998 – 07/2003
Bachelor in Pediatrics Chongqing Medical University
WORKING EXPERIENCE
02/2016 – Current Associate professor, Department of Physiology, Basic Medical College, Chongqing Medical University
02/2015 – 02/2016 Visiting scholar funded by the National Scholarship Council, Dana-Farber Cancer Institute, Harvard University
09/2013 – 02/2015 Associate professor, Department of Physiology, Basic Medical College, Chongqing Medical University
07/2010 – 09/2013 Lecturer, Department of Physiology, Basic Medical college, Chongqing Medical University
07/2003 – 07/2005 Teaching Assistant, Department of Physiology, Basic Medical College, Chongqing Medical University
RESEARCH INTERESTS
Molecular Oncology, Cancer Genetics, Signal Transduction, Targeted Therapy for Cancer.
PUBLICATIONS
1. Sang, Bo-tao, Wang, Chang-dong, Guo, Jia-qi, Wu, Xiang-mei. Transformation of Human Umbilical Vein Endothelial Cells Induced by the Tumor Microenvironment of Nephroblastoma Cells . J EVOL BIOCHEM PHYS. 2023, 59(2): 411- 419.
2. Bo-Tao Sang , Chang-Dong Wang, Xing Liu, Jia-Qi Guo, Jia-Yi Lai, Xiang-Mei Wu.
PDGF-BB/PDGFRβ induces tumour angiogenesis via enhancing PKM2 mediated by the PI3K/AKT pathway in Wilms' tumour. Med Oncol. 2023 Jul 14, 40(8): 240.
3. Hu-Ying Tang, Jia-Qi Guo, Bo-Tao Sang, Jun-Ning Cheng, Xiang-Mei Wu. PDGFRβ modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K/AKT/mTOR/c-Myc pathway. Chem Cell Biol. 2022, 100(1): 75-84.
4. Jia-Qi Guo, Chang-Dong Wang, Hu-Ying Tang, Bo-Tao Sang, Xing Liu , Fa-Ping
Yi, Xiang-Mei Wu. Influence of Dichloroacetate on Wilms'Tumor in vitro. Ann Clin Lab Sci.2022, 52(1): 101-108.
5. Jia‐qi Guo, Chang‐dong Wang, Hu‐ying Tang, Bo‐tao Sang, Xing Liu, Fa‐ping Yi,Xiang‐mei Wu. PDGF-BB/PDGFRβ promotes epithelial-mesenchymal transition by affecting PI3K/AKT/mTOR-driven aerobic glycolysis in Wilms' tumor G401 cells. Cell Biol Int. 2022, 46(6): 907-921.
6. Sining Xing, Changdong Wang, Huying Tang, Jiaqi Guo, Xing Liu, Faping Yi, Geli Liu, Xiangmei Wu. Downregulation of PDGFRβ suppresses invasion and migration in osteosarcoma cells by influencing epithelial-mesenchymal transition. FEBS Open Bio. 2020, 10(9): 1748-1757.
7. 邢思宁, 唐瑚应, 郭佳琪, 刘星, 汪长东, 易发平, 刘革力, 武向梅. 血小板衍生生长因子受体β对骨肉瘤细胞株HOS增殖的影响.《基因组学与应用生物学》. 2020, 39 (6): 2820-2826.
8. Peng Y, Xing SN, Tang HY, Wang CD, Yi FP, Liu GL, Wu XM. Influence of glucose transporter 1 activity inhibition on neuroblastoma in vitro. Gene. 2019, 689: 11-17.
9. 彭妍, 邢思宁, 唐瑚应, 刘星, 汪长东, 易发平, 刘革力, 武向梅. 抑制葡萄糖转运蛋白1表达可降低神经母细胞瘤细胞的增殖、侵袭和迁移能力.细胞与分子免疫学杂志.2018, 34 (11): 994-999.
10. Wu XM, Liu X, Jiao QF, Fu SY, Bu YQ, Song FZ, Yi FP*, Cytotoxic T lymphocyteselicited by dendritic cell-targeted delivery of human papillomavirus type-16 E6/E7 fusion gene exert lethal effects on CaSki cells. Asian Pac J Cancer Prev. 2014, 15(6): 2447-51.
11. Xiangmei Wu, Xing Liu, Joyeeta Sengupta, Youquan Bu, Faping Yi, Changdong Wang, Yanyan Shi, Yong Zhu, Qingfang Jiao, Fangzhou Song. Silencing of the Bmi-1 gene by RNA interference enhances sensitivity to doxorubicin in breast cancer cells. Indian J Exp Biol. 2011 Feb, 49: 105-112.
