PERSONAL INFORMATION
Name: Tang Qing
Gender: Female
Title: Prof.
Position: Associate professor from School of Basic Medical Sciences
CONTACT INFORMATION
Email: tangqingzoe@cqmu.edu.cn
Address: Yixueyuan Road, Yuzhong District, Chongqing 400016, P.R.China
Phone: +86-13452112693
EDUCATION EXPERIENCE
2007.09-2011.06: BS, Chemical Engineering and Pharmaceutical Sciences, Southwest University
2011.09-2014.06: MS, Pharmaceutical Analysis, Southwest University
2015.09-2019.12: PhD (Supervised by Prof. Xiaoyu Xu), Biopharmaceutical Sciences, Southwest University
2017.03-2019.12: Visiting PhD student (Supervised by Prof. Jiou Wang), Biochemistry and Molecular Biology, Johns Hopkins University
WORKING EXPERIENCE
2014.07-2015.08: Research assistant, Institute for Brain Function Rehabilitation and Developmental Imaging, Nanchong Central Hospital
2020.01-2022.02: Postdoctoral fellow, Department of Biochemistry and Molecular Biology, Johns Hopkins University
2022.05 to now: Associate professor, Neuroscience Research Center, Chongqing Medical University
2023.03 to present: Associate professor, Department of Physiology, Chongqing Medical University
RESEARCH INTERESTS
Prof. Tang is committed to the discovery of novel targets and drug development for the treatment of neurological diseases. Her most recent work mainly focuses on repairing lysosomal homeostasis and enhancing protein quality control in neurodegenerative diseases (NDs), such as Amyotrophic lateral sclerosis and Alzheimer’s disease. Currently, Prof. Tang is involved in three research projects, primarily funded by the National Natural Science Foundation of China, the Chongqing Municipal Education Commission, and the Chongqing Medical University.
Given the complex pathogenesis of NDs, there are currently no effective therapeutic drugs to alleviate the suffering of patients with these conditions. Prof. Tang’s team pays attention to the dysfunction of lysosomes and the toxic aggregation of misfolded proteins in ND patients. They employed whole-genome CRISPR screening to identify potential genes associated with the repair of lysosomal function. Subsequently, they verified the robust ones and clarified their cellular roles in lysosome regulation and protein quality control. Several related articles have been published in The EMBO Journal and BioEssays. In future work, Prof. Tang’s team will dedicate themselves to uncovering more targets for therapeutic interventions and delving deeper into the mechanisms underlying lysosomal dysfunction and misfolding protein aggregation in NDs.
HONOUR & AWARDS
1. Young Innovative Talent at Chongqing Medical University
2. Chongqing Municipal Science and Technology Progress Award – Second Prize
3. Third Prize of the Science and Technology Award by the Chinese Association of Traditional Chinese Medicine
PUBLICATIONS
1. Qing Tang, Xiangning Li, Jiou Wang*. Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases. BioEssays. 2022, 44(11): e2200110.
2. Qing Tang, Mingming Liu, Yang Liu, Ran-Der Hwang, Tao Zhang, Jiou Wang*. NDST3 deacetylates α-tubulin and suppresses V-ATPase assembly and lysosomal acidification. The EMBO Journal. 2021, 40(19): e107204.
3. Qing Tang, Hui Ke, Chao Wu, Jie Zeng, Zhuohen Li, Yang Liu, Shan Feng, QiangXue, Xiaoyu Xu*. Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure mice through targeting hippocampal CaMKIIα/CREB/BDND and EPO/EPOR pathways. Journal of Ethnopharmacology, 2019, 239: 111925.
4. Jiayin Lu#, Goran Periz#, Yu-Ning Lu#, Qing Tang, Yang Liu, Tao Zhang, Yajas Shah, Ravi Thombre, RehamAljumaah, Weixin Li, Jelena Mojsilovic-Petrovic, Yon Ji, Kenji Johnson, Robert Kalb, Jiou Wang*. L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control. Nature Neuroscience, 2019, 22: 875-886.
5. Qing Tang#, Sheng Yang#, Jie Tong, Xu Li, Junjie Wu, Senhong Wang, Jifen Zhang, Yi Chen, Xiaoyu Xu*. Hemostasis and uterine contraction promoting effect of the extract from drugs in the Zi-Yin-Tiao-Jing granule, a traditional Chinese compound preparation. Journal of Ethnopharmacology, 2018, 211: 278-284.
6. Qing Tang, Guangming Li, Tao Liu, Anguo Wang, Shenggang Feng, Xiang Liao, Yu Jin, Zhiwei Guo, Bin He, Morgan A. McClure, Guoqiang Xing, Qiwen Mu*. Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: systematic review and meta-analysis of fMRI studies. Neuroscience and Biobehavioral Reviews. 2015, 57: 392-400.
7. Qing Tang, Guangming Li, Anguo Wang, Tao Liu, Shenggang Feng, Zhiwei Guo, Huaping Chen, Bin He, Morgan A. McClure, Jun Ou, Guoqiang Xing, Qiwen Mu*. A systematic review for the antidepressant effects of sleep deprivation with repetitive transcranial magnetic stimulation. BMC Psychiatry. 2015, 15: 282.
8. Qing Tang, Fanghong Shang, Xiaocui Wang, Yang Yang, Gang Chen, Yi Chen, Jifen Zhang, Xiaoyu Xu*. Combination use of ferulic acid, ligustrazine and tetrahydropalma- tine inhibits the growth of ectopic endometrial tissue: a multi-target therapy for endometriosis rats. Journal of Ethnopharmacology, 2014, 151(3): 1218-1225.
