PERSONAL INFORMATION
Name: Song Fangzhou
Gender: Male
Nationality: China
CONTACT INFORMATION
Email: fzsongcq@163.com
EDUCATION EXPERIENCE
Professor Song Fangzhou graduated with a bachelor's degree from Southwest University in 1982, a master's degree from Southwest University in 1985, and a doctoral degree from Kyushu University in Japan from 1993 to 1998.
WORKING EXPERIENCE
(1) From July 2015 to present, Professor/Director, School of Basic Medicine, Chongqing Medical University
(2) 2007.11-2015.06, Professor/Vice Dean, School of Basic Medicine, Chongqing Medical University
(3)2003.12-2007.11, Professor/Director, School of Basic Medicine, Chongqing Medical University
(4)2003.05-2003.11 Researcher, Functional Genomics Research Center, Department of Medicine, Kyushu University, Japan
(5) 2001.07- 2003.05, Professor/Director, School of Basic Medicine, Chongqing Medical University
(6) 1998.09 -2001.06, Professor and Dean, Silk College, Southwest University
RESEARCH INTERESTS
Professor Song Fangzhou is mainly engaged in functional and applied research on important human functional genes, especially malignant tumor related genes such as NFBD1, MCHR2, PRR11, IL-18, IL-24, HPV-16 E6/E7, etc. The latest research techniques in molecular medicine, such as RNAi, have been used to systematically study the functions of these new genes at the molecular, cellular, and individual levels, elucidating their biological functions and molecular behavioral mechanisms in the occurrence and development of diseases such as malignant tumors. And on this basis, further use genetic engineering and other technical means to carry out applied research on human disease diagnosis, gene therapy, and drug development targeting these functional genes. In addition, we will focus on conducting differential proteomic research on benign, borderline, and malignant tumors of the female reproductive system (cervical and ovarian), providing new targets for their treatment.
HONOUR & AWARDS
He has won one first prize for scientific and technological progress in Sichuan Province, one third prize for scientific and technological progress in Chongqing City, one first prize for excellent teaching achievements in Chongqing City, and one second prize for excellent teaching achievements in Sichuan Province. He has obtained five national invention patents. He is a recipient of special government subsidies from the State Council, a middle-aged and young expert with outstanding contributions at the provincial and ministerial levels, a recipient of the first batch of the "Key Teacher Program for Higher Education Institutions" project by the Ministry of Education, a part-time doctoral supervisor at Huazhong University of Science and Technology, a leader in key disciplines of biochemistry and molecular biology in Chongqing, and one of the first batch of professor level science and technology consulting experts in Chongqing.
PUBLICATIONS
[1]Bian X, Fan N, Li M, Han D, Li J, Fan L, Li X, Kong L, Tang H, Ding S, Song F*, Li S*, Cheng W*. An ER-Horse Detonating Stress Cascade for Hepatocellular Carcinoma Nanotherapy. ACS Nano. 2023 Mar 14;17(5):4896-4912.
[2]Lulu Xu#; Zheng Zhou#; Xiaolong Gou; Weicheng Shi; Yao Gong; Ming Yi;
Wei Cheng*; Fangzhou Song*; Light up multiple protein dimers on cell surfacebased on proximity-induced fluorescence activation of DNA-templated slivernanoclusters, Biosensors and Bioelectronics, 2021, 179(2).
[3]Song J, Tang Y, Luo X, Shi X,Song F*, Ran L*. Pan-Cancer Analysis Reveals the Signature of TMC Family of Genes as a Promising Biomarker for Prognosis and Immunotherapeutic Response. Front Immunol. 2021 Nov 9;12:715508.
[4]Song J, Tang Y,Song F*. Lnc-RGS5 sponges miR-542-5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation. Int J Oncol. 2023 Oct;63(4):111.
Cao LX[5] Pan WW, Yi FP, , Liu XM, Shen ZF, Bu YQ, Xu Y, Fan HY, Song FZ*,. DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage. Gene. 2013 Sep 10;526(2):287-94.
[6] Zhu H, Guo FJ, Zhao W, Zhou J, Liu Y, Song F*, Wang Y. ATF4 and IRE1α inhibit DNA repair protein DNA-dependent protein kinase 1 induced by heat shock. Mol Cell Biochem. 2012 Dec;371(1-2):225-32.
[7] Huang J, Shen L, Lu Y, Li H, Zhang X, Hu D, Feng T, Song F*. Parallel induction of cell proliferation and inhibition of cell differentiation in hepatic progenitor cells by hepatitis B virus X gene. Int J Mol Med. 2012 Oct;30(4):842-8.
[8] Ji Y, Xie M, Lan H, Zhang Y, Long Y, Weng H, Li D, Cai W, Zhu H, Niu Y, Yang Z, Zhang C, Song F, Bu Y. PRR11 is a novel gene implicated in cell cycle progression and lung cancer. Int J Biochem Cell Biol. 2013 Mar;45(3):645-56.
[9] Yuan C, Bu Y, Wang C, Yi F, Yang Z, Huang X, Cheng L, Liu G, Wang Y, Song F*. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem. 2012 Jan; 359(1-2):333-46
[10] Wu X, Liu X, Sengupta J, Bu Y, Yi F, Wang C, Shi Y, Zhu Y, Jiao Q, Song F*. Silencing of Bmi-1 gene by RNA interference enhances sensitivity to doxorubicin in breast cancer cells. Indian J Exp Biol. 2011 Feb; 49(2):105-12.
