PERSONAL INFORMATION
Name: Chunguang Ren
Gender: Male
Title: Professor
Position: Lab head of the Laboratory of Developmental Biology, Chongqing Medical University.
CONTACT INFORMATION
Email: chunguangren@cqmu.edu.cn & ren_chunguang@163.com
Address: 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P.R.China.
Phone: +86-13124831084
EDUCATION EXPERIENCE
Sept. 2006 – Jul. 2013 Ph.D. in Developmental Biology
Institute of Health Sciences, Chinese Academy of Science＆Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China
Sept. 2002 – Jul. 2006 B.S. of Biological Science
Wuhan University, P. R. China
WORKING EXPERIENCE
Jan. 2020 - Present Professor
Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University
Oct. 2018 – Dec. 2019 Associate Research Scientist
Department of Pharmacology, School of Medicine, Yale University
Oct. 2013 – Sept. 2018 Postdoctoral Associate
Department of Pharmacology, School of Medicine, Yale University
RESEARCH INTERESTS
My laboratory focuses on studying the functional and molecular mechanism in inflammatory microenvironments, providing theoretical support for understanding and treating human inflammatory diseases. Our current research projects include: 1) Using zebrafish and mouse models to explore new regulatory genetic factors and molecular mechanisms for neutrophil behaviors in inflammatory microenvironments; 2) Using mouse disease models and human clinical samples to study the function and mechanism of neutrophil-enriched genes in pulmonary inflammatory diseases such as chronic obstructive pulmonary disease and acute lung injury.
PUBLICATIONS
1. Zhang H, Meng L, Liu Y, Jiang JL, He ZT, Qin JJ, Wang CH, Yang MT, He K, Yang J, Chen KT, He QK, Tang WW, Fan SJ*, Ren CG*. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. Journal of Immunology. 2023 Aug 1;211(3):462-473. doi: 10.4049/jimmunol.2200863 (IF2023 = 4.4)
2. Ren CG#, Yuan QY, Jian XY, Randazzo PA, Tang WW, Wu DQ. Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization. Journal of Immunology. 2020 Feb 15;204(4):1012-1021. （IF2020 = 5.422）
3. Ren CG#, Yuan QY#, Braun M, Zhang X, Petri B, Zhang JS, Kim D, Guez-Haddad J, Xue WZ, Pan WJ, Fan R, Kubes P, Sun ZX, Opatowsky Y, Polleux F, Karatekin E, Tang WW, Wu DQ. Leukocyte cytoskeleton polarization is initiated by plasma membrane curvature from cell attachment. Developmental Cell. 2019 April 22；49, 206–219. （IF2019 = 10.092）
4. Chan EC#, Ren CG#, Xie Z, Jude JA, Barker T, Koziol-White CA, Ma M, Panettieri RA Jr, Wu D, Rosenberg HF, Druey KM. Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking. Journal of Biological Chemistry. 2018 Aug 17;293(33):12690-12702. （IF 2018 = 4.106）
5. Yuan QY#, Ren CG#, Xu WW, Petri B, Zhang JS, Zhang Y, Kube P, Wu DQ, Tang WW. PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Reports. 2017 June 20; 19(12):2586–2597. （IF 2017 = 8.032）
6. Ren CG*, Wang L, Jia XE, Liu YJ, Dong ZW, Jin Y, Chen Y, Deng M, Zhou Y, Zhou Y, Ren RB*, Pan WJ*, Liu TX. Activated N-Ras signaling regulates arterial-venous specification in Zebrafish. Journal of Hematology & Oncology. 2013 May 12; 6:34. （IF 2013 = 4.933）
7. Wang R#, Wang Y#, Liu N#, Ren CG#，Jiang C, Zhang K, Yu S, Chen YF, Tang H, Deng Q, Fu C, Wang YC, Li R, Liu MY, Weijun Pan,Ping Wang. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research. 2013. Jun;23(6):803-19. （IF 2013 = 11.981）
