PERSONAL INFORMATION
Name: Xinyi Mu
Gender: Female
Title: associate professor
Position: deputy director of department of Histology & Embryology
CONTACT INFORMATION
Email: muxinyi@cqmu.edu.cn
Address: 1 Yixueyuan Road, Yuzhong District, Chongqing 400016
Phone: +86-18680767420
EDUCATION EXPERIENCE
2007 – 2012: Ph.D. of Physiology
Department of Physiology, China Agricultural University, Beijing.
2003 – 2007: Bachelor of Biotechonology
College of Biological Sciences, Nanjing University of Chinese Medicine.
WORKING EXPERIENCE
2013 – present: associate professor
College of Basic Medicine, Chongqing Medical University.
2012-2013 assistant researcher
Reproduction & genetics institution, Chongqing healthy centre for women and children.
RESEARCH INTERESTS
My research aims to reveal the molecular control of oogenesis to understand the mechanisms of female reproductive disorders. As major events of mammalian oogenesis occurs at the fetal stage, her particular interests lie in the early development of the oocyte, especially the initiation of meiosis, meiotic homologous recombination and primordial folliculogenesis. Since the entire ovarian reserve is established during this early stage, and disruption may lead to long-lasting consequences in the reproductive lifespan, I also interests in the effects of environmental endocrine disruptors and toxicants on these events. My work focused on the vulnerable window of oogenesis. I am now exploring the involvement of epigenetic alterations during oogenesis, including post-transcriptional and post-translational modifications.
PUBLICATIONS
(As first or coresponding author)
1. Qiqi Liu#, Junlin He, Xuemei Chen, Yi Hong, Fangfang Li, Yanqing Geng, Yan Zhang, Lamptey Jones, Zhuxiu Chen, Fangfei Liu, Yingxiong Wang, Xinyi Mu*. Fetal exposure of Aristolochic Acid I undermines ovarian reserve by disturbing primordial folliculogenesis. Ecotoxicol Environ Saf. 2022. doi: 10.1016/j.ecoenv.2022.113480.
2. Mu Xinyi#, Tu Zhihan, Chen Xuemei, Hong Yi, Geng Yanqing, Zhang Yan, Ji Xingduo, Liu Taihang, Wang Yingxiong, He Junlin*, In Utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice. Frontiers in cell and developmental biology. 2021, 9: 669732, doi: 10.3389/fcell.2021.669732.
3. Yi Hong#, Xinyi Mu#, Xingduo Ji, Xuemei Chen, Yanqing Geng, Yan Zhang, Qiqi Liu, Fangfang Li, Yingxiong Wang, Junlin He*, In-utero exposure to HT-2 toxin affects meiotic progression and early oogenesis in foetal oocytes by increasing oxidative stress. Environmental Pollution. 2021, 279:116917. doi: 10.1016/j.envpol.2021.116917
4. Tu Zhihan#, Mu Xinyi#, Chen Xuemei, Geng Yanqing, Zhang Yan, Li Qingying, Gao Rufei, Liu Taihang, Wang Yingxiong, He Junlin*, Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes. Environmental Pollution.2019, 252: 388-398. doi: 10.1016/j.envpol.2019.05.107
5. Tu Zhihan#, Mu Xinyi#, Li Qingying, Gao Rufei, Zhang Yan, Chen Xuemei, Geng Yanqing, Wang Yingxiong, He Junlin*, Autophagy participates in cyst breakdown and primordial folliculogenesis by reducing ROS levels in perinatal mouse ovaries. J Cell Physiol. 2019, 234(5):6125-6135. doi: 10.1002/jcp.27367.
6. Zhang Yan#, Mu Xinyi#, Gao Rufei, Geng Yanqing, Liu Xueqing, Chen Xuemei, Wang Yuheng, Ding Yubin, Wang Yingxiong, He Junlin*, Foetal-neonatal exposure of Di (2-ethylhexyl) phthalate disrupts ovarian development in mice by inducing autophagy. J Hazard Mater. 2018, 15;358:101-112. doi: 10.1016/j.jhazmat.2018.06.042
7. Mu Xinyi#, Wen Jia#, Chen Qian, Wang Zhengpin, Wang Yijing, Guo Meng, Yang Yi, Xu JinRui, Wei Zhiqing, Xia Guoliang, Yang Mengye,Wang Chao*, Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biology Open (2018) 7, bio035626. doi: 10.1242/bio.035626
8. Mu Xinyi# , Liao Xinggui, Chen Xuemei, Li Yanli, Wang Meirong, Shen Cha, Zhang Xue, Wang Yingxiong, Liu Xueqing,H, Junlin*, DEHP exposure impairs mouse oocyte cyst breakdown and primordial follicle assembly through estrogen receptor-dependent and independent mechanisms. J Hazard Mater, 2015, 298：232-240. doi: 10.1016/j.jhazmat.2015.05.052
9. Mu Xinyi#, Wen Jing, Guo Meng, Wang Jianwei, Li Ge, Wang Zhengpin, Wang Yijing, Teng Zhen, Cui Yan, Xia Guoliang*, Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells., Journal of Cellular Physiology, 2013, 228（3）：627-639. doi: 10.1002/jcp.24172
10. Zhu Jiahong# ,Mu Xinyi#, Zeng Jin, Xu Chunyan, Liu Jun, Zhang Mengsi, Li Chengpeng, Chen Jie, Li Tinyu, Wang Yaping*, Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLos One, 2014, 9（6）：e101291-e101291. doi: 10.1371/journal.pone.0101291
11. Mu Xinyi#, Zhang Yanyan, Li Jing, Xia Jieyu, Chen Xiongbin, Jing Pengwei, Song Xiaoying, Wang Lu, Wang Yaping *, Angelica Sinensis Polysaccharide prevents hematopoietic stem cells senescence in Dgalactose- induced aging mouse model., Stem cell international. 2017:3508907. doi: 10.1155/2017/3508907.
