PERSONAL INFORMATION
Name: Yunlong Lei
Gender: Male
Title: Professor
Position: Vice director
CONTACT INFORMATION
Email: leiyunlong@cqmu.edu.cn
Address: Yixueyuan Road 1#, Yuzhong District,
Chongqing, 400016, P.R.China
Phone: +86-02368485991
EDUCATION EXPERIENCE
2004.09-2008.06 Biotechnology, Bachelor, Sichuan University
2008.09-2013.06 Biochemistry and Molecular Biology, PhD, Sichuan University
WORKING EXPERIENCE
2021.11 till now, Chongqing Medical University, College of Basic Medical Sciences, Professor
2021.04 till now, Chongqing Medical University, Molecular Medicine and Cancer Research Center, Vice director
2018.09-2021.10, Chongqing Medical University, College of Basic Medical Sciences, Associate Professor
2013.07-2018.09, Chongqing Medical University, College of Basic Medical Sciences, Assistant Professor
RESEARCH INTERESTS
1. Redox signaling, metabolism and autophagy in cancer
2. Chemical proteomics identifying drug targets
HONOUR & AWARDS
1. The youth talent support program of Chongqing.
2. The First Prize of Natural Science Award of the Ministry of Education in 2020 (6/11).
PUBLICATIONS
1. Fan H, He Y, Xiang J, Zhou J, Wan X, You J, Du K, Li Y, Cui L, Wang Y, Zhang C, Bu Y, Lei Y*. ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy. Redox biology. 2022;53:102339.
2. Fan X, Wang Y, Jiang T, Liu T, Jin Y, Du K, Niu Y, Zhang C, Liu Z, Lei Y*, Bu Y*. B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2. Oncogene, 2021;40(37):5613-5625.
3. Zhou J#, Zhang L#, Wang M#, Zhou L, Feng XP, Yu LL, Lan J, Gao W, Zhang CD, Bu YQ, Huang CH, Zhang HY*, Lei YL*. CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer. Theranostics. 2019;9(19):5577-94.（
4. Yan, JH; Dou, XY; Zhou, J; Xiong, YF; Mo, L; Li, LH*; Lei, YL*. Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation. Journal of Experimental and Clinical Cancer Research, 2019, 38(1): 0-353.
5. Wang K#, Zhang T#, Lei Y#, Li X#, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Peng Y, Nice EC, et al. Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux. Autophagy. 2018; 14(2):269-282.
6. Zhou J, Liu H, Zhang L, Liu X, Zhang C, Wang Y, He Q, Zhang Y, Li Y, Chen Q, Zhang L, Wang K, Bu Y and Lei Y. DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis. Cell death & disease. 2018; 9(9):865.
7. Feng X, Zhou J, Li J, Hou X, Li L, Chen Y, Fu S, Zhou L, Li C and Lei Y. Tubeimoside I induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function. Cell death & disease. 2018; 9(11):1117.
8.Wan, X., J. Xiang, H. Fan, Y. Jiang, Y. Lu, C. Zhang, Y. Zhang, Q. Chen*, and Y. Lei*. Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma. Pharmaceuticals (Basel).2023; 16 (1).
9. Lei YL#, Wang K#, Li XF#, Li Y, Feng XP, Zhou J, Zhang Z, Huang CH and Zhang T. Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice. Clin Sci. 2019; 133(7):789-804.
10. Yuan K#, Lei Y#, Chen HN#, Chen Y#, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu M, Xiang R, Nice EC, Wei Y and Huang C. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. Cell death and differentiation. 2016; 23(4):616-627.
