PERSONAL INFORMATION
Name: Aishun JIN, Ph.D.
Gender: Female
Title: Director, Department of Immunology,
College of Basic Medicine
Position: Professor
CONTACT INFORMATION
Email: aishunjin@cqmu.edu.cn
EDUCATION EXPERIENCE
Bachelor, Preventive Medicine, College of Public Health, Harbin Medical University, Harbin, P.R.China. 1988
Ph.D., Department of Hematology /Oncology, Tokyo Medical and Dental University, Tokyo, Japan 2006
WORKING EXPERIENCE
2017-present Professor, Department of Immunology, College of Basic Medicine, Chongqing Medical University, P.R.China
2010-2017 Professor, Department of Immunology, College of Basic Medicine, Harbin Medical University, P.R.China
2006-2010 Post-doctoral fellow, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
2000-2002 Visiting research fellow Department of Immunology and Biochemistry, Institute of Medical Science, University of Tokyo, Tokyo, Japan
1988-1999 Institute of Viral Diseases, Center for Disease Control (CDC) of HeilongJiang Province, Heilongjiang, P.R.China
RESEARCH INTERESTS
Research in JIN’s laboratory focuses on the molecular mechanisms of T/B lymphocyte activation and development in the field of basic medicine, and translational research of TCR-T cell immunotherapy and development of Ab drug for solid tumors.
HONOUR & AWARDS
Chongqing Talents & Innovation Leader
PUBLICATIONS
Tumor Immunology
1. Siyin Chen; Jing Zhang; Meiying Shen; Xiaojian Han; Shenglong Li; Chao Hu; Wang Wang; Luo Li; Li Du; Da Pang; Kun Tao; Aishun Jin. p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-β. International Immunopharmacology, 2021, 98: 107848.
2. Li Du; Yaru Nai; Meiying Shen; Tingting Li; Jingjing Huang; Xiaojian Han; Wang Wang; Da Pang; Aishun Jin. IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities. Frontiers in Molecular Biosciences, 2021, May ( 8) 675179
3. Yaru Nai; Li Du; Meiying Shen; Tingting Li; Jingjing Huang; Xiaojian Han; Feiyang Luo; Wang Wang; Da Pang; Aishun Jin. TRAIL-R1-targeted CAR-T cells exhibit dual antitumor efficacy. Frontiers in Molecular Biosciences, 2021, 8: 756599.
4. FengXia Gao; SiRong He; AiShun Jin. MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma.Genes & Diseases, 2020, 20(20)
5. Lu Guo, Xin Sun, Zhichao Hao, Jingjing Huang, Xiaojian Han, Yajie You, Yaying Li, Meiying Shen, Tatsuhiko Ozawa, Hiroyuki Kishi, Atsushi Muraguchi, and Aishun Jin*. Identification of Novel Epitopes with Agonistic Activity for the Development of Tumor Immunotherapy Targeting TRAIL-R1. Journal of Cancer 2017 8(13): 2542-2553
6. Hao Z, Han X, Sun X, Shen M, Huang J, Li Y, Ozawa T, Pang D, Jin S, Kishi H, Muraguchi A, Jin A*. Fully human monoclonal antibodies to TRAIL-R1 enhance TRAIL-induced apoptosis via activation of caspase-8 pathway. Biochem Biophys Res Commun.2016 Jun 24;475(2):238-44.
7. Kobayashi E, Mizukoshi E, Kishi H, Ozawa T, Hamana H, Nagai T, Nakagawa H, Jin A, Kaneko S, Muraguchi A.A new cloning and expression system yields and validates TCRs from blood lymphocytes of patients with cancer within 10 days. Nat Med. 2013 Nov;19(11):1542-6.
8. Jin A*, Ozawa T, Tajiri K, Obata T, Kishi H*, Muraguchi A.Rapid isolation of antigen-specific antibody-secreting cells using a chip-based immunospot array. Nat Protoc. 2011 May;6(5):668-76.
9. Jin A*, Ozawa T, Tajiri K, Lin Z, Obata T, Ishida I, Kishi H*, Muraguchi A.Generation of TRAIL-receptor 1-specific human monoclonal Ab by a combination of immunospot array assay on a chip and human Ab-producing mice. Eur J Immunol. 2010 Dec;40(12):3591-3.
10. Jin A, Ozawa T, Tajiri K, Obata T, Kondo S, Kinoshita K, Kadowaki S, Takahashi K, Sugiyama T, Kishi H, Muraguchi A.A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood. Nat Med. 2009 Sep;15(9):1088-92.
11. A Jin, T Kurosu, D Mizuchi, A Arai,H Fujita, M. Httori, N Minato and O Miura. BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis and adhesion. Oncogene (2006) 25,4332-4340.
SARS-CoV-2 新冠病毒中和抗体及中和机制研究
12. Xiaojian Han; Yingming Wang; Shenglong Li; Chao Hu; Tingting Li; Chenjian Gu; Kai Wang; Meiying Shen; Jianwei Wang; Jie Hu; Ruixin Wu; Aishun Jin. A Rapid and Efficient Screening System for Neutralizing Antibodies and Its Application for SARS-CoV-2, frontiers in immunology, 2021, 2021 Mar 22
13. Tingting Li; Xiaojian Han; Chenjian Gu; Hangtian Guo; Huajun Zhang; Yingming Wang; Chao Hu; Kai Wang; Fengjiang Liu; Feiyang Luo; Yanan Zhang; Jie Hu; Wang Wang; Shenglong Li; Yanan Hao; Meiying Shen; Jingjing Huang; Yingyi Long; Shuyi Song; Ruixin Wu; Song Mu; Qian Chen; Youhua Xie; Haitao Yang; Bo Zhang; Ailong Huang; Aishun Jin. Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.Nature communications, 2021, 12(1): 6304
14. A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding.Yingyi Long; Shuyi Song; Feiyang Luo; Xiaojian Han; Chao Hu; Yingming Wang; Shenglong Li; Wang Wang; Huajun Zhang; Bo Zhang; Tingting Li; Aishun Jin. Biochemical and Biophysical Research Communications, 2021, 571: 152-158.
15. Chao Hu; Meiying Shen; Xiaojian Han; Qian Chen; Luo Li; Siyin Chen; Jing Zhang; Fengxia Gao; Wang Wang; Yingming Wang; Tingting Li; Shenglong Li; Jingjing Huang; Jianwei Wang; Ju Zhu; Dan Chen; Qingchen Wu; Kun Tao; Da Pang; Aishun Jin. Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants. Genes & Diseases, 2022, 9(1): 216-2295.
16. Shenglong Li; Wang Wang; Tingting Li; Xiaojian Han; Chao Hu; Yingming Wang; Meiying Shen; Li Du; Yaru Nai; Jianwei Wang; Aishun Jin. Immune characteristics analysis reveals two key inflammatory factors correlated to the expressions of SARS-CoV-2 S1-specific antibodies.Genes & Diseases, 2020, 2020 Dec 23(2020 Dec 23)
17. Luo Li; Qian Chen; Xiaojian Han; Meiying Shen; Chao Hu; Siyin Chen; Jing Zhang; Yingming Wang; Tingting Li; Jingjing Huang; Shenglong Li; Yanan Hao; Aishun Jin.T cell immunity evaluation and immunodominant epitope TCR identification to SARS-CoV-2 spike glycoprotein in COVID-19 convalescent patients. frontiers in cell and developmental biology, 2021, 3(9): 696662
18. Fengxia Gao; Jingjing Huang; Tingting Li; Chao Hu; Meiying Shen; Song Mu; Feiyang Luo; Shuyi Song; Yanan Hao; Wang Wang; Xiaojian Han; Chen Qian; Yingming Wang; Ruixin Wu; Luo Li; Shenglong Li; Aishun Jin. A highly conserved peptide vaccine candidate activates both humoral and cellular immunity against SARS-CoV-2 variant strains. frontiers in immunology, 2021, 12: 789905
