PERSONAL INFORMATION
Name: Fengjin Guo
Gender: Female
Title: Professor
CONTACT INFORMATION
Email: guo.fengjin@cqmu.edu.en
Address: No. 1, Yixueyuan Road, Yuzhong District, Chongqing 400016, China.
EDUCATION EXPERIENCE
2001-2006 MD, PhD, Clinical laboratory diagnosis; Chongqing Medical University, Chongqing, China
1990-1994 B. S., Cell Biology; Lanzhou University, Lanzhou, China
WORKING EXPERIENCE
2020- Present Distinguished Professor, Department of Cell Biology and Genetics, Chongqing Medical University
2009- Present Professor, Department of Cell Biology and Genetics, Chongqing Medical University
2007-2008 Associate Research Scientist, Department of Orthopaedic Surgery and cell biology, New York University School of Medicine, New York, NY
2004-2009 Associate Professor, Department of Cell Biology and Genetics, Chongqing Medical University
1999-2004 Lecturer, Department of Cell Biology and Genetics, Chongqing Medical University
1994-1999 Assistant, Department of Cell Biology and Genetics, Chongqing Medical University
RESEARCH INTERESTS
bone, cartilage development and genetics diseases, basics and clinical research of bone/joint damage, regeneration repair and Drug R & D.
HONOUR & AWARDS
2014 Natural Science Award of Chongqing (principal investigator)
2012 New Century Excellent Talent Support Project of Education Ministry of China
2012 Chongqing "Five four Youth Red-banner Pacesetter"
2011 University Excellent Talent Support Project of Chongqing Education Committee
MEMBERSHIP IN SCIENTIFIC ORGANIZATIONS
Vice chairman, bone nutrition and health special committee of Chinese Nutrition Society
Member, the Matrix Biology Special Committee of the Chinese Physiological Society
Lifetime member, International Chinese Musculoskeletal Research Society
Member, American Society for Bone and Mineral Research (ASBMR)
Director, ChongQing Society of Genetics,
Director, ChongQing Society of Cell Biology,
PUBLICATIONS
1. Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo#. Protection of IRE1α against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. Experimental & Molecular Medicine (IF=12.8, Q1), inpress.
2. Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin,Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng,Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi,Qiaoyan Tan , Yangli Xie, Fengjin Guo#.IRE1a regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization. Genes & Diseases (IF=7.243, Q2). Genes Dis. 2024 Dec 29;11(1):464-478.
3. Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo#. Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling. ACS Nano (IF=18.027, Q1). 2021 Oct 26;15(10): 15874-15891.
4.Xiaoli Li, Yuyou Yang, Li Liang, Mengtian Fan, Xingyue Li, Naibo Feng, Yiming Pan, Qiaoyan Tan, Qingbo Xu, Yangli Xie, Fengjin Guo#. Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA mRNA. International Journal of Biological Sciences (IF=10.75, Q1. 2022; 18(1): 315-330.
5. YimingPan,YuyouYang, MengtianFan, ChengChen, RongJiang, LiLiang, MenglinXian, BiaoKuang, NanaGeng, Naibo Feng, Lin Deng, Wei Zheng, Fengmei Zhang, Xiaoli Li, Fengjin Guo#. Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis. Genes Dis. (IF=7.243, Q2), 2022 Jun 13;10(4):1582-1595.
6. Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan , Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo#. Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway. J Mol Med (IF=5.606, Q2).2022 Aug; 100(8):1191-1207.
7. Naibo Feng, Fengjin Guo#. Nanoparticle-siRNA: A potential strategy for rheumatoid arthritis therapy? J Control Release (IF=10.8, Q1). 2020 Sep 10; 325: 380-393.
8. Qin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo#. The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK. FEBS J. 2020 Jun;287(11):2348-2366.
9. W Zheng, W Xie, D Yin, R Luo, M Liu, Fengjin Guo#. ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling. Cell Commun Signal. 2019 May 6;17(1):42.
10. W Xie, W Zheng, M Liu, Q Qin,Y Zhao, Z Cheng, Fengjin Guo#. BRF1 ameliorates LPS-induced inflammation through autophagy crosstalking with MAPK/ERK signaling. Genes Dis. 2018 Apr 27; 5(3):226-234.
11. FengJin Guo#, Han X, Wu Z, Cheng Z, Hu Q, Zhao Y,Wang Y, Liu Chuanju. ATF6a, a Runx2-activable transcription factor, is a new regulator of chondrocyte hypertrophy. J Cell Sci..2016;129: 717-728.
12. Fengjin Guo, Yongjie Lai, Qingyun Tian, Li Kong, Edward A. Lin, Chuan-ju Liu. Granulin-Epithelin Precursor (GEP) Binds Directly to ADAMTS-7 and ADAMTS-12 and Inhibits Their Degradation of Cartilage Oligomeric Matrix Protein. Arthritis & Rheumatism (IF=15.8, Q1), 2010, 62(7): 2023-2036.
13. JQ Feng*, Fengjin Guo*(co-first author), Jiang BC, Zhang Y, Liu CJ, et al. Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis. FASEB J. 2010 Jun;24(6):1879-1892.
14. Fengjin Guo#, Xiong Z, Han X, Liu C, Liu Y, Jiang R, Zhang P. XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor. J Cell Mol Med. 2014 Jun;18(6):1157-71.
15.Yunpeng Zhao, Cheng Qiu, Wenhan Wang, Jiangfan Peng, Xiang Cheng, Yangtao Shangguan, Mingyang Xu, Jiayi Li, Ruize Qu, Xiaomin Chen, Suyi Jia, Dan Luo, Long Liu, Peng Li, Fengjin Guo, Krasimir Vasilev, Liang Liu, John Hayball, Shuli Dong, Xin Pan, Yuhua Li, Linlin Guo, Lei Cheng, Weiwei Li. Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation. Theranostics. 2020 May 27;10(15):7015-7033.
16. L Kuang, J Wu, N Su, H Qi, H Chen, S Zhou, Y Xiong, X Du, Q Tan, J Yang, M Jin, F Luo, J Ouyang, B Zhang, Z Wang, W Jiang, L Chen, S Chen, Z Wang, P Liu, L Yin, F Guo, C Deng, D Chen, C Liu, Y Xie, Z Ni, L Chen. FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.Ann Rheum Dis. 2020 Jan;79(1):112-122.
17. R Gao, LQ Ma, X Du, TT Zhang, L Zhao, L Liu, JC Liu, F Guo, Z Cheng, H Huang.Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity. Oncotarget. 2016 Apr 26;7(17):23850-9.
18. L Kong, Q Tian, Fengjin Guo, MT Mucignat, CJ Liu, et al. Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth. Matrix Biol. 2010 May; 29(4):276-286.
19. Wei Tang, Yi Lu, Qingyun Tian, Yan Zhang, Fengjin Guo, Guangyi Liu, Nabeel Muzaffar Syed, Yongjie Lai, Edward Alan Lin, Li Kong, Jeffrey Su, Fangfang Yin, Aihao Ding, Alexandra Zanin-Zhorov, Michael L. Dustin, Jian Tao, Joseph Craft, ZhinanYin, Jian Q. Feng, Steven B. Abramson, Xiu-Ping Yu, Chuanju Liu. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. SCIENCE.2011 Apr 22; 332(6028):478-484.
