PERSONAL INFORMATION
Name: Wanyan Deng
Gender: Female
CONTACT INFORMATION
Email: dengwanyan@cqmu.edu.cn
EDUCATION EXPERIENCE
2006.9 – 2010.6 Biotechnology, Bachelor, Jianghan University
2010.9 – 2015.12 Microbiology, PhD, Southwest University
2013.10-2015.09 Microbiology, PhD (Joint)，University of Pennsylvania
WORKING EXPERIENCE
2022.12 - present, Professor, Chongqing Medical University
2019.01-2022.06, Postdoctor, Institut Pasteur Shanghai, Chinese Academy of Sciences.
2016.7-2018.12, Research associate, The Second Affiliated Hospital, Chongqing Medical University.
RESEARCH INTERESTS
Focus on pathogen-host interaction:1) reveal how the virulence factors of pathogens interfere with the host immune response. 2) study the molecular mechanism of host anti-pathogen immune response and reveal novel pathways and regulatory factors involved in host-pathogen interactions. 3) screen small molecule inhibitors for infectious and inflammatory diseases treatment.
PUBLICATIONS
1. Wanyan Deng*, Yang Bai*, Fan Deng*, Youdong Pan*, Shenglin Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, Rui Miao, Zhibin Zhang, Thomas S Kupper, Judy Lieberman and Xing Liu#. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature, doi:10.1038/s41586-021-04384-4 (2022).
2. Zengzhang Zheng*, Wanyan Deng*, Yang Bai*, Rui Miao*, Shenglin Mei, Zhibin Zhang, Youdong Pan,Yi Wang, Rui Min, Fan Deng, Zeyu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, Judy Lieberman#, Xing Liu#. The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia. Science 372, doi:10.1126/science.abg0269 (2021).
3. Wanyan Deng*, Tiwei Fu, Zhen Zhang, Xiao Jiang, Jianping Xie, Hang Sun, Peng Hu, Hong Ren, Peifu Zhou, Qi Liu, Quanxin Long#. L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake. Emerg Microbes Infect 9, 639-650, doi:10.1080/22221751.2020.1740611 (2020).
