PERSONAL INFORMATION
Name: Xianjun Chen
Gender: Male
Title: Associate professor
CONTACT INFORMATION
Email: chenxianjun@cqmu.edu.cn
Address: 1 Yixueyuan Rd, Yuzhong District, Chongqing
Phone: +86-18623149737
EDUCATION EXPERIENCE
WORKING EXPERIENCE
2018-2019 Assistant Researcher, Mental Diseases Prevention and Treatment Institute of PLA
2020- Associate Researcher, Chongqing Medical University, Department of Physiology
RESEARCH INTERESTS
I am very interested in oligodendrocyte and myelin dynamics in normal brain function, development and brain diseases. Our current research focuses on how genetic and epigenetic risk factors affect myelination and contribute to the white matter etiology of major mental illnesses.
PUBLICATIONS
1. Haoqian Wu, Xianjun Chen, Bin Yu, Jieqiong Zhang, Xingmei Gu, Wei Liu, Feng Mei, Jian Ye, Lan Xiao. Deficient deposition of new myelin impairs adult optic nerve function in a murine model of diabetes, Glia, 2023, Jan 20. (co-first)
2. Mei Li, Lan Xiao, Xianjun Chen. Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia, Frontiers in Cellular Neuroscience, 2022, 16 (823708). (co-corresponding)
3. Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen and Lan Xiao. DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice, Frontiers in Neuroscience, 2021, 15 (659853).
4. Xianjun Chen, Hao Liu, Jingli Gan, Xiaorui Wang, Guangdan Yu, Tao Li, Xuejun Liang, Bin Yu and Lan Xiao. Quetiapine Modulates Histone Methylation Status in Oligodendroglia and Rescues Adolescent Behavioral Alterations of Socially Isolated Mice, Frontiers in Psychiatry, 2020, 10 (984).
5. Xianjun Chen, Fei Wang, Jingli Gan, Zhonghua Zhang, Xuejun Liang, Tao Li, Nanxin Huang, Xiaofeng Zhao, Feng Mei, Lan Xiao. Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice, Neuroscience Bulletin, 2020, 36(4): 419–426.
6. Xianjun Chen, Huifeng Duan, Lan Xiao and Jingli Gan. Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders, Frontiers in Genetics, 2018, 9 (565).
7. Xianjun Chen, Li Ku, Ruyi Mei, Guanglu Liu, Chongchong Xu, Zhexing Wen, Xiaofeng Zhao, Fei Wang, Lan Xiao and Yue Feng. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development, Translational Psychiatry, 2017, 7 (1293).
8. Xianjun Chen, Weiguo Zhang, Tao Li, Yu Guo, Yanping Tian, Fei Wang, Shubao Liu, Hai-Ying Shen, Yue Feng, Lan Xiao. Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice, Frontiers in Cellular Neuroscience, 2015, Dec 15;9:467.
9. Fei Wang, Yu-Jian Yang, Nian Yang, Xianjun Chen, Nan-Xin Huang, Jun Zhang, Yi Wu, Zhi Liu, Xing Gao, Tao Li, Guang-Qiang Pan, Shu-Bao Liu, Hong-Li Li, Stephen P J Fancy, Lan Xiao, Jonah R Chan, Feng Mei. Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia, Neuron, 2018 Aug 22;99(4):689-701.
10. Guangdan Yu, Yixun Su, Chen Guo, Chenju Yi, Bin Yu, Hui Chen, Yihui Cui, Xiaorui Wang, Yuxin Wang, Xiaoying Chen, Shouyu Wang, Qi Wang, Xianjun Chen, Xuelian Hu, Feng Mei, Alexei Verkhratsky, Lan Xiao, Jianqin Niu. Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model, Molecular Psychiatry, 2022 Dec;27(12):5154-5166.
