PERSONAL INFORMATION
Name: Junxia Chen
Gender: Female
Title: Professor
CONTACT INFORMATION
Email: chjunxia@126.com
Phone: +86-68485868
EDUCATION EXPERIENCE
Ph.D. Biochemistry and Molecular Biology, Dalian Medical University; 09/2001-7/2004
M.S. Cell Biology, West China Medical University; 09/1988~07/1991
B.S. Biology, Southwestern Normal University; 09/1982~07/1986
WORKING EXPERIENCE
Assistant, July 10, 1986-Aug 31, 1988, College of Applied Technology, Chongqing Medical University.
Associate professor, Lecturer, Assistant, July. 1991-May 20, 2005, Dalian Medical University.
Professor, associate professor, May 21, 2005-Now, Basic Medical College, Chongqing Medical University.
RESEARCH INTERESTS
Study on the Function and Mechanism of NoncodingRNA in Tumors
HONOUR & AWARDS
Has won multiple awards for excellent thesis advisor at the municipal and school levels, as well as excellent graduate supervisor. Also, has won the first prize in the 4th National College Students' Basic Medical Innovation Forum and Experimental Design Competition as a mentor.
PUBLICATIONS
1. Rui Yang , Hang Chen, Lei Xing, Bin Wang, Mengting Hu, Xiaoqiang Ou, Hong Chen, Yumei Deng, Dawei Liu, Rong Jiang, Junxia Chen* . Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10. Mol Cancer. 2022, 21(1):88.(IF: 37. 3).
2. Xiaosong Wang, Lei Xing, Rui Yang, Hang Chen, Min Wang, Rong Jiang, Luyu Zhang, Junxia Chen*. The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC. Mol Cancer. 2021, 20(1):91. (IF: 41. 444).
3. Zheng X, Huang M, Xing L, Yang R, Wang X, Jiang R, Zhang L, Chen J*. The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer. Mol Cancer. 2020, 19(1):73.(IF: 27. 401),
4. Chen H, Yang R, Xing L, Wang B, Liu D, Ou X, Deng Y, Jiang R, Chen J*. Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation. Int J Biol Sci. 2022, 18(9):3888-3907. (IF:9.2 ).
5. Wang B, Chen H, Deng Y, Chen H, Xing L, Guo Y, Wang M, Chen J*. CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway. J Transl Med. 2023, 21(1):186. (IF:7.4 ).
6. Zhong Z, Huang M, Lv M, He Y, Duan C, Zhang L, Chen J*. Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progressionthrough modulating VEGFA/VEGFR2 signaling pathway. Cancer Lett. 2017, 10;403:305-317. (IF: 6. 375).
7. Xing L, Yang R, Wang X, Zheng X, Yang X, Zhang L, Jiang R, Ren G, Chen J*. The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis.Aging (Albany NY). 2020, 12(11):10983-11003.(IF:5.682 ).
8. Yang R, Xing L, Wang M, Chi H, Zhang L, Chen J*. Comprehensive Analysis of Differentially Expressed Profiles of lncRNAs/mRNAs and miRNAs with Associated ceRNA Networks in Triple-Negative Breast Cancer. Cell Physiol Biochem. 2018, 50(2):473-488. (IF: 5.5).
9. Wang B, Xiao H, Yang X, Zeng Y, Zhang Z, Yang R, Chen H, Chen C, Chen J*. A novel immune-related microRNA signature for prognosis of thymoma. Aging (Albany NY). 2022, 14(11):4739-4754. 15. (IF:5.2).
10. Zhuang X, Lv M, Zhong Z, Zhang L, Jiang R, Chen J*. Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladdercancer through signaling ILK pathways. J Exp Clin Cancer Res. 2016, 30;35(1):130. (IF: 5. 189).
11. Lv M, Zhong Z, Huang M, Tian Q, Jiang R, Chen J*. lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA. Biochim Biophys Acta Mol Cell Res. 2017,1864(10):1887-1899.(IF:4.651 ).
12. Zhong Z, Lv M, Chen J*. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 2016, 36:30919. (IF: 4. 259).
13. Chi H, Yang R, Zheng X, Zhang L, Jiang R, Chen J*. LncRNA RP11-79H23.3 Functions as a Competing Endogenous RNA to Regulate PTEN Expression through Sponging hsa-miR-107 in the Development of Bladder Cancer.Int J Mol Sci. 2018, 19(9):2531.(IF: 4.183).
14. Lv M, Zhong Z, Chi H, Huang M, Jiang R, Chen J*. Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin β1 Signaling Pathways in Bladder Carcinoma. .Int J Mol Sci. 2016, 18(1):78. (IF:3.226 ).
15. Wang B, Chen H, Yang R, Xing L, Chen C, Chen J*. LncRNA RP11-551L14.4 suppresses breast cancer development by inhibiting the expression of miR-4472.
Peer J. 2022, 10:e14482.(IF:2.7 ).
