PERSONAL INFORMATION
Name: Youquan BU
Gender: Male
Title: Professor
Position: Director
CONTACT INFORMATION
Email: buyqcn@aliyun.com, buyqcn@cqmu.edu.cn
Address: 1# Yixueyuan Road, Yuzhong District, ChongQing 400016 China
Phone: +86-23-68485991(Office)
EDUCATION EXPERIENCE
September 2004 ~ July 2007, Ph.D in Medical Molecular Biology. ChongQing Medical University.
September 1998 ~ July 2001, MSc in Biochemistry and Molecular Biology. Southwest University.
WORKING EXPERIENCE
March 2009 ~ at present, Director, Department of Biochemistry and Molecular Biology, ChongQing Medical University.
April 2021 ~ at present, Director, Molecular Medicine and Cancer Research Center, ChongQing Medical University.
October 2013 ~ at present, Professor, Department of Biochemistry and Molecular Biology, ChongQing Medical University.
March 2005 ~ March 2007, visiting scholar, Division of Biochemistry, Chiba Cancer Center.
RESEARCH INTERESTS
Cancer genomics and epigenomics; Cancer bioinformatics; Lung cancer and colorectal cancer; Gene regulation network; Non-coding RNA.
HONOUR & AWARDS
ChongQing Society of Biochemistry and Molecular Biology (Council member); ChongQing Society of Cell Biology (Council member); Chinese Society of Biochemistry and Molecular Biology (Membership); Chinese Society for Cell Biology (Membership); Chinese Society of Biochemistry and Molecular Biology, Terminology Working Committee (Member & Secretary); Encyclopedia of Chinese Medicine (Biochemistry Volume Editorial Committee Member); China National Committee for Terminology in Science and Technology (Member for Biochemical and Molecular Biology); Genes & Diseases (Associate Editor); Chinese Journal of Biochemistry and Molecular Biology (Editorial board member).
PUBLICATIONS
1. Fan X#, Wang Y#, Jiang T#, Liu T#, Jin Y, Du K, Niu Y, Zhang C, Liu Z, Lei Y*, Bu Y*. B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2. Oncogene. 2021 Sep;40(37):5613-5625.
2. Du K#, Sun S#, Jiang T#, Liu T, Zuo X, Xia X, Liu X, Wang Y*, Bu Y*. E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. Int J Biol Sci. 2022 Jun 25;18(10):4151-4170.
3. Xu D#, Qiao D#, Lei Y, Zhang C, Bu Y*, Zhang Y*. Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer. Cancer Letters. 2022 Oct 10;546:215842.
4. Zuo X#, Meng P#, Bao Y, Tao C, Wang Y, Liu X, Bu Y*, Zhu J*. Cell cycle dysregulation with overexpression of KIF2C/MCAK is a critical event in nasopharyngeal carcinoma. Genes & Diseases. 2023 Jan;10(1):212-227.
5. Zhang L, Zhang Y, Lei Y, Li Y, Wei Z, Wang Y, Bu Y*, Zhang C*. Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma. J Biol Chem. 2020 Apr 17;295(16):5335-5349.
6. Zhang N, Jiang T, Wang Y, Wang S, Hu L, Bu Y*. BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis. Genes (Basel). 2020 Feb 19;11(2). pii: E217.
7. Liu X#, Liu T#, Hu L, Jiang T, Liu H, Wang Y, Lei Y, Zhu J, Bu Y*. Identification and characterization of the promoter of cancer-related gene LOXL2. Exp Cell Res. 2020 Feb 15;387(2):111786.
8. Hu L#, Chen Q#, Wang Y, Zhang N, Meng P, Liu T, Bu Y*. Sp1 Mediates the Constitutive Expression and Repression of the PDSS2 Gene in Lung Cancer Cells. Genes (Basel). 2019 Nov 27;10(12). pii: E977.
9. Wang Y, Zhang C, Mai L, Niu Y, Wang Y, Bu Y*. PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer. BMB Rep. 2019 Feb;52(2):157-162.
10. Xie M, Bu Y*. SKA2/FAM33A: A novel gene implicated in cell cycle, tumorigenesis, and psychiatric disorders. Genes & Diseases. 2019 Mar; 6(1):25-30.
11. Wang S, Wang K, Zhang C, Zhang W, Xu Q, Wang Y, Zhang Y, Li Y, Zhang Y, Zhu H, Song F, Lei Y*, Bu Y*. Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. Cell Death Dis. 2017 Oct 5;8(10):e3087.
12. Fan X, Wang Y, Jiang T, Cai W, Jin Y, Niu Y, Zhu H, Bu Y*. B-Myb mediates proliferation and migration of non-small-cell lung cancer via suppressing IGFBP3. Int J Mol Sci. 2018 May 16;19(5). pii: E1479.
13. Feng X, Zhang C, Zhu L, Zhang L, Li H, He L, Mi Y, Wang Y, Zhu J*, Bu Y*. DEPDC1 is required for cell cycle progression and motility in nasopharyngeal carcinoma. Oncotarget. 2017 Jun 29;8(38):63605-63619.
14. Wang Y#, Zhang C#, Jin Y#, Wang S, He Q, Liu Z, Ai Q, Lei Y, Li Yi, Song F, Bu Y*. Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. Sci Rep. 2017 Mar 15;7:44573.
15. Wang Y, Weng H, Zhang Y, Long Y, Li Y, Niu Y, Song F, Bu Y*. The PRR11-SKA2 bidirectional transcription unit is negatively regulated by p53 through NF-Y in lung cancer cells. Int J Mol Sci. 2017 Mar 1;18(3). pii: E534.
16. Jin Y, Zhu H, Cai W, Fan X, Wang Y, Niu Y, Song F*, Bu Y*. B-Myb is up-regulated and promotes cell growth and motility in non-small cell lung cancer. Int J Mol Sci. 2017 May 27;18(6).
17. Liu H, Liu X, Zhang C, Zhu H, Xu Q, Bu Y*, Lei Y*. Redox Imbalance in the Development of Colorectal Cancer. J Cancer. 2017 Jun 3;8(9):1586-1597.
18. Zhang C, Zhang Y, Li Y, Zhu H, Wang Y, Cai W, Zhu J, Ozaki T, Bu Y*. PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC). Biochem Biophys Res Commun. 2015 Mar 13;458(3):501-508.
19. Wang Y#, Zhang Y#, Zhang C#, Weng H#, Li Y, Cai W, Xie M, Long Y, Ai Q, Liu Z, Du G, Wang S, Niu Y, Song F, Ozaki T, Bu Y*. The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2015 Sep;1849(9):1133-1144.
20. Ji Y#, Xie M#, Lan H#, Zhang Y, Long Y, Weng H, Li D, Cai W, Zhu H, Niu Y, Yang Z, Song F, Bu Y*. PRR11 is a novel gene implicated in cell cycle progression and lung cancer. Int J Biochem Cell Biol. 2013 Mar;45(3):645-656.
