PERSONAL INFORMATION
Zhijie Han, Ph.D.
Associate Professor, Master's Supervisor,
Hong Kong Scholar
Department of Bioinformatics,
School of Basic Medicine,
Chongqing Medical University
No. 1 Yixueyuan Road, Yuzhong, Chongqing, China
E-mail: zhijiehan@cqmu.edu.cn
EDUCATION EXPERIENCE
2020 Ph.D. in Bioinformatics, Innovative Drug Research Center, Chongqing University, China. Doctoral thesis: “Identification and Function Analysis of Multiple Sclerosis Related LncRNAs Based on GWAS and RNA-seq Data” .
2016 M.S. in Bioinformatics, Key Laboratory for Biological Big Data of Ministry of Education, Harbin Institute of Technology, China. Master thesis: “Meta analysis and Biologiical Pathway GSEA Research of Lung Cancer GWAS Data” .
2012 B.S. in Biological Science, College of Life Science, Guizhou University, China. Undergraduate thesis: “Using mathematical modeling to analyze the mortality of Tetranychus urticae infested by Hirsutella thompsonii” .
WORKING EXPERIENCE
Jul, 2020 - now, Associate Professor, Department of Bioinformatics, School of
Basic Medicine, Chongqing Medical University.
Feb, 2013 - Dec, 2013, Research Assistant, Burn Institute, Army Medical University.
Jul, 2010 - Dec, 2012, Research Assistant, Institute of Fungus Resources, Guizhou University
RESEARCH INTERESTS
Based on bioinformatics approaches, the research interests focus on the pathogenesis of human central nervous system (CNS) and neurological disorders (e.g. Alzheimer's disease, multiple sclerosis, etc.) at the genomic and transcriptomic levels. These mainly involve genomic and transcriptomic data analysis, next generation sequencing data analysis, single cell sequencing data analysis, GWAS, SNP, lncRNA, eQTL, meta-analysis,
Mendelian randomization, algorithm, and database development.
PROFESSIONAL AFFILIATIONS
Topic Editor of Frontiers in Immunology
Topic Editor of Frontiers in Pharmacology
Topic Editor of Frontiers in Public Health
Topic Editor of Frontiers in Neuroscience
Topic Editor of Frontiers in Genetics
Topic Editor of Frontiers in Neurology
Topic Editor of Frontiers in Neuroinformatics
Editorial Board Member of Exploratory Research and Hypothesis in Medicine
Editorial Board Member of Journal of Geriatric Medicine
Committee Member of Neural Regeneration and Repair Committee of Chinese Research Hospital Association
Committee Member of Chongqing Bioinformatics Association
GRANTS/HONORS/AWARDS
Research on the comprehensive QTL study of genome-wide regulation of lncRNAs by SNPs in human brain by integrating multi-omics data, National Natural Science Foundation of China (Grant No. 32200446): 2023.01-2025.12, 300 000 Yuan (RMB) in China.
Constructing a gene expression regulation map of the human brain and precise treatment of cognitive function alteration, CQMU Program for Youth Innovation in Future Medicine (Grant No. W0147): 2023.01-2025.12, 500 000 Yuan (RMB) in
China.
Research on the mechanism of COVID- 19 on the risk of common neurological diseases based on the MR CAUSE method and scRNA-seq analysis, Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202100402): 2021.10-2024.09, 40 000 Yuan (RMB) in China.
The start-up fund of Chongqing Medical University (Grant No. R1017): 2020.09- 2024.08, 300 000 Yuan (RMB) in China.
Hong Kong Scholars Program, Ministry of Human Resources and Social Security of the People's Republic of China/ The Government of HKSAR, 2023.
Zhang Xijun Foundation 16th National Youth Academic Paper Outstanding Wall
Paper Award, Chinese Association for Physiological Sciences, 2021.
Highly Cited Award of WILEY Publishing, USA, 2019.
National scholarship for Postgraduates of China, 2015.
3rd Prize of Contemporary Undergraduate Mathematical Contest in Modeling (CUMCM) of China, 2011.
3rd Prize of Contemporary Undergraduate Mathematical Contest in Modeling (CUMCM) of China, 2010.
PUBLICATIONS
1.Huang L, Wang Y, Tang Y, He Y, Han Z* Lack of causal relationships between Chronic Hepatitis C virus infection and Alzheimer's disease. Front Genet. 2022,
13:828827.
2. Yang Z, He Y, Wang Y, Huang L, Tang Y, He Y, Chen Y, Han Z* Genome-Wide Analysis for the Regulation of Gene Alternative Splicing by DNA Methylation Level
in Glioma and Its Prognostic Implications. Front Genet. 2022, 13:799913.
3. He Y, Huang L, Tang Y, Yang Z, Han Z* Genome-wide Identification and Analysis of Splicing QTLs in Multiple Sclerosis by RNA-Seq Data. Front Genet. 2021,
12:769804.
4. He Y, Wang L, Tang J*, Han Z* Genome-wide identification and analysis of the methylation of lncRNAs and prognostic implications in the glioma. Front Oncol.
10:607047.
5. Han Z, He D, et al. Genetic variant rs7820258 regulates the expression of indoleamine 2,3-dioxygenase 1 in brain regions. Proc. Natl. Acad. Sci. U.S.A. 2020,
117: 24035-24036.
6. Han Z, Xue W, et al. Genome-wide identification and analysis of the eQTLlncRNAs
in multiple sclerosis based on RNA-seq data. Brief Bioinform. 2020, 21: 1023- 1037.
7. Han Z, Wei B, et al. PARK16 rs708730 polymorphism decreases Parkinson’s Disease risk in European ancestry population: a meta-analysis. Journal of Geriatric Medicine.
2019; 1:15-22.
8. Han Z, Hua J, et al. Integrating the RNA-seq data from various studies to explore
multiple sclerosis-related lncRNAs and their functions. Front Genet. 2019; 10: 1136.
9. Han Z, Xue W, et al. Identification of key long non-coding RNAs in the pathology of Alzheimer's Disease and their functions based on genome-wide associations study,
microarray, and RNA-seq data. J AlzheimersDis. 2019; 68: 339-355.
10. Han Z, Xue W, et al. Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis. CNS
Neurosci Ther. 2018; 24: 1253- 1263.
11. Han Z, Qu J, et al. Genetic variant rs755622 regulates expression of the multiple sclerosis severity modifier D-dopachrome tautomerase in a sex-specific way. Biomed
ResInt. 2018; 2018: 8285653.
12. Han Z, Qu J, et al. Analyzing 74,248 samples confirms the association between CLU rs11136000 polymorphism and Alzheimer's Disease in caucasian but not Chinese
population. Sci Rep. 2018; 8: 11062.
13. Han Z, Jiang Q, et al. Analyzing large-scale samples confirms the association between the rs1051730 polymorphism and lung cancer susceptibility. Sci Rep. 2015;5: 15642.
14. Han Z, Qu J, et al. Using mathematical modeling to analyze the mortality of Tetranychus urticae infested by Hirsutella thompsonii. Chinese Journal of Applied
Entomology. 2013; 50: 406-412.
15. Yang S, Yi L, Xia X, Chen X, Hou X, Zhang L, Yang F, Liao J, Han Z, Fu Y. Transcriptome comparative analysis of amygdala-hippocampus in depression: A rat model induced by chronic unpredictable mild stress (CUMS). Journal of Affective
Disorders. 2023; 334:258-270.
16. Tang, J, Wang, Y, Fu, J, Wu, X, Han Z, Wang C, Guo M, Wang Y, Ding Y, Yang B,
Zhu F. Functional characterization of disease/comorbidity-associated lncRNA.
Quantitative Biology. 2021; 9.
17. Ding W, Xu L, Zhang L, Han Z, Jiang Q, Wang Z, Jin S. Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus. BMC Med
Genet. 2018; 19: 38.
18. Tan R, Wang J, Wu X, Wan G, Wang R, MaR, Han Z, Zhou W, Jin S, Jiang Q ERDS- pe: A paired hidden Markov model for copy number variant detection from whole- exome sequencing data. In: Bioinformatics and Biomedicine (BIBM), 2016 IEEE International Conference on, 2016. IEEE, pp 141- 144.
19. Jiang Q, Wang J, Wu X, Ma R, Zhang T, Jin S, Han Z, Tan R, Peng J, Liu G, Li Y, Wang Y. LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. Nucleic Acids Res. 2015; 43: D193- 196.
