PERSONAL INFORMATION
HE, GUIQIONG
Degrees/ Credentials : MD, PhD
Titles: Professor; Department of Anatomy,
Basic Medical College, CQMU
Director; Institute of Neuroscience,
Basic Medical College, CQMU
Address: Rm706 , 7 th floo r , Library Building,
No. 1 Yi Xue Yuan Road, Yu Zhong District,
Chongqing, 400016
Phone: 86- 13220276708
Email: guiqionghe@cqmu.edu.cn
EDUCATION EXPERIENCE
2004-2007 University of British Columbia, Vancouver, BC, Canada
Chongqing Medical University, Chongqing, China
PhD in Neurology, Advisor: Sun Shanquan(CQMU), Song Weihong (UBC)
1997-2000 Chongqing Medical University, Chongqing, China
MD in Human Anatomy, Advisor: Sun Shanquan
1991- 1996 Chongqing Medical University, Chongqing, China
Bachelor in Clinical Medicine
TEACHING EXPERIENCE
1997- at present Department of Anatomy, Chongqing Medical University, Chongqing, China
Assistant lecturer, Lecturer, Associate professor and professor in Human Anaotmy
Teaching Chinese students: Systematic Anatomy, Regional Anatomy, Neuroanatomy, Sectional Anatomy, Anaesthetic Anatomy, Integrated Medical Courses. Teaching International students: Systematic Anatomy, Regional Anatomy, from 2001
2000 .7 - 12 The Chinese University of HongKong, Hongkong, China
Visiting Scholar, Human Anatomy
2019 .9- 10 The University of Leicester, Leicester, United Kingdom
Visiting Scholar, Integrated Medical Courses
RESEARCH EXPERIENCE AND INTERESTS
2004- 2006 University of British Columbia, Vancouver, BC, Canada
Visiting Scholar in Neuroscience. Advisor: Song Weihong
Research: The neuropathogenesis and therapy of Alzheimer's disease
2008 - at present Institute of Neuroscience, Chongqing Medical University, Chongqing, China
Director, PI. The molecular mechanisms and treatment of neurodegenerative disease
HONOUR OR AWARDS
Ministry of Education"Outstanding Talents of the New Century" award
Advanced individual in Chongqing oversea Abroad Program
COMPILING TEXTBOOKS
1. 《Systematic Anatomy》, bilingual edition, Science Press. Writing part: The meninges and blood vessels of spinal cord and brain and circulation of CSF. Chief Editor: Liu Zhiyu (2009)
2 . 《 Systematic Anatomy》, Science Press. Writing part: The nervous pathway. Chief Editor: Kang
Jian (2009)
3. 《 Introduction to Basic Medicine 》 , People's Medical Publishing House. Writing part: The nervous system and sensory organs. Chief Editor: Deng Shixiong (2012)
4. 《 Regional Anatomy 》 ,8th edition, People's Medical Publishing House. Writing part: Case analysis. Chief Editor: Liu Shuwei (2013)
5 . 《Systematic Anatomy》, Science Press. Writing part: The general description of nervous system, the central nervous system, and the nervous pathway. Chief Editor: Sun Jun(2014)
6 . 《 Regional Anatomy》, People' s Medical Publishing House. Writing part: Thorax. Chief Editor: Zhang Shaoxiang (2015)
7 . Integrated Medical Course Textbooks: 《 Sensory organs disease 》, People' s Medical Publishing House. Writing part: Ear. Chief Editor: Hu Guohua, Zhou Shanbi (2016)
8 . Integrated Medical Course Textbooks:《Nervous system disease and mental disease》,
People's Medical Publishing House. Writing part: Cerebrum. Chief Editor: Xie Peng (2017)
9. 《 Regional Anatomy 》 ,9th edition, People's Medical Publishing House. Writing part: Case analysis. Chief Editor: Li Ruixi (2018)
10. 《 Systematic Anatomy 》,2th edition, Science Press. Writing part: Nervous Pathway. Chief Editor: Cai changping (2019)
11 . 《 Systematic Anatomy 》, English edition, Xian Jiaotong University Press. Writing part: The Spinal cord. Chief Editor: Feng Gaifeng (2020)
12. 《Regional Anatomy》,2th edition, Science Press. Writing part: Supra-colic region. Chief Editor: Cai changping (2021)
PUBLICATIONS (REPRESENTATIVES)
1. He J#, Liu Y#, Li J, Zhao Y, Jiang H, Luo S*, He G*. Intestinal changes in permeability, tight junction and mucin synthesis in an Alzheimer’s disease model mice. International Journal of Molecular Medicine （IJMM） (accepted)
2. Li J#, Wang L#, Zeng Q, He J, Tang Q, Wang K*, He G*. MKP- 1 regulates inflammatory activation of microglia against Alzheimer's disease. CNS Neurosci Ther, 2023 (in press)
3. Long Z#, Ge C#, Zhao Y, Liu Y, Zeng Q, Tang Q*, Dong Z*, He G*. HDAC6 inhibition by VPA increases V-ATPase assembly and lysosomal acidification in Alzheimer's disease
models. Biomedicine & Pharmacotherapy, 2023 (revised)
4. Zhang R, Jiang H, Liu Y, He G*.Structure, function, and pathology of Neurexin-3.Genes Dis.
2022 Apr 30;10(5):1908- 1919. doi: 10. 1016/j.gendis.2022.04.008. eCollection 2023 Sep.
5. Jiang H, Feng Y, He G, Liu Y*, Li X*. Analysis of the expression and distribution of protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 in the normal adult mouse
brain.Front Neuroanat. 2023 Jan 6;16:1043924. doi: 10.3389/fnana.2022.1043924. eCollection 2022.
6. Yang Q, Song D, Xie Z, He G, Zhao J, Wang Z, Dong Z, Zhang H, Yang L, Jiang M, Wu Y, Shi Q, Li J, Yang J, Bai Z, Quan Z, Qing H. Optogenetic stimulation of CA3 pyramidal
neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice. Prog Neurobiol. 2022 Feb;209:102209. doi: 10. 1016/j.pneurobio.2021.102209. Epub 2021 Dec 22.
7. Lin S, Zhou FQ, Cheng JB, Sun XD, He G. Editorial: The role of astrocyte in vascular aging. Front Aging Neurosci. 2022 Aug 3;14:961288. doi: 10.3389/fnagi.2022.961288. eCollection 2022.
8. MacPherson MJ, Erickson SL, Kopp D, Wen P, Aghanoori MR, Kedia S, Burns KML,
Vitobello A, Tran Mau-Them F, Thomas Q, Gold NB, Brucker W, Amlie-Wolf L, Gripp KW, Bodamer O, Faivre L, Muona M, Menzies L, Baptista J, Guegan K, Male A, Wei XC, He G, Long Q, Innes AM, Yang G. Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates. Cell Rep. 2021 Jun 8;35(10):109226. doi: 10. 1016/j.celrep.2021.109226.
9. Feng Y, Jiang H, Li G, He G, Li X. Decreased expression of protein O-linked mannose β- 1,2- N-acetylglucosaminyltransferase 1 contributes to Alzheimer's disease-like pathologies.J
Neurophysiol. 2022 Apr 1;127(4):1067- 1074. doi: 10. 1152/jn.00362.2021. Epub 2022 Mar 23.
10. Qiu Y, Zhao YY, Long ZM, Song AJ,Huang P, Wang KJ, Xu L, Molloy DP, He G*.
Liquiritigenin Promotes Osteogenic Differentiation And Prevents Bone Loss Via Inducing Auto-lysosomal Degradation And Inhibiting Apoptosis. Genes Dis. 2021 Jul 13;10(1):284- 300. doi: 10. 1016/j.gendis.2021.06.008. eCollection 2023 Jan.
11. Ren M#, Feng M#, Long Z, Ma J, Peng X*, He G*.Allergic asthma-induced cognitive
impairment is alleviated by Dexamethasone. Front Pharmacol. 2021 Jun 23;12:680815. doi: 10.3389/fphar.2021.680815.
12. Zhou W, Xiao D, Zhao Y, Tan B, Long Z*, Yu L*, He G*.Enhanced Autolysosomal
Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease. Front Aging Neurosci. 2021 Feb 23;13:629891. doi:
10.3389/fnagi.2021.629891.
13. Zhao YY# ,Long ZM#, Liu YJ, Luo M, Qiu Y, Idris NFB, Song AJ, Wang KJ* and He G*.
Dihydroartemisinin Ameliorates Decreased Neuroplasticity-Associated Proteins and
Excessive Neuronal Apoptosis in APP/PS1 Mice. Curr Alzheimer Research, 2020;17(10):916 -925 doi: 10.2174/1567205017666201215124746
14. Du Y, Luo M, Du Y, Xu M, Yao Q, Wang K, He G*. Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice. Neurotox Res. 2021 Apr;39(2):349-358. doi: 10. 1007/s12640-020-00284-z
15. Li YZ#, Liu YJ#, Zhang W, Luo SF, Zhou X, He G*. Combined treatment with valproic acid and estrogen exerts neuroprotective effect on ovariectomized Alzheimer’s disease mouse
models. Neural Regen Res, 2021 Oct1, 16(10):2078-2085
16. Luo M#, Zeng QH#, Jiang K, Zhao YY, Long ZM, Du YH, Wang KJ, He G*. Estrogen
deficiency exacerbates learning and memory deficits in APP/PS1 double transgenic female mice associated with glucose metabolism disorder. Genes Dis. 2021 Feb 16;9(5):1315- 1331. doi: 10. 1016/j.gendis.2021.01.007. eCollection 2022 Sep.
17. Du Y, Du Y, Zhang Y, Huang Z, Fu M, Li J, Pang Y, Lei P, Wang YT, Song W*, He G*,
Dong Z*. MKP- 1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer's disease models. Signal Transduct Target Ther. 2019 Dec 6;4:58. doi: 10. 1038/s41392-019-
0091-4. eCollection 2019.
18. Rodrigues DC, Harvey EM, Suraj R, Erickson SL, Mohammad ML, Ren M, Liu H, He G, Kaplan DR, Ellis J, Yang G. Methylglyoxal Couples Metabolic and Translational Control of Notch Signalling in Mammalian Neural Stem Cells. Nat Commun. 2020 Apr 24;11(1):2018. doi: 10. 1038/s41467-020- 15941-2.
19. Long Z, Chen J, Zhao Y, Zhou W, Yao Q, Wang Y, He G*. Dynamic Changes of Autophagic Flux Induced by Abeta in the Brain of Postmortem Alzheimer's Disease Patients, Animal
Models and Cell Models. Aging (Albany NY), 2020 Jun 13;12(11):10912- 10930. doi: 10. 18632/aging.103305.
20. Zhao Y, Long Z, Ding Y, Jiang T, Liu J, Li Y, Liu Y, Peng X, Wang K, Feng M*, He G*. Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through
Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance. Front Aging Neurosci, 2020 Mar 2;12:47. doi: 10.3389/fnagi.2020.00047.
21. Cao Z, Wang Y, Long Z, He G*. Interaction between autophagy and the NLRP3
inflammasome. Acta Biochim Biophys Sin (Shanghai), 2019 Nov 18;51(11): 1087- 1095. doi:
10. 1093/abbs/gmz098.
22. Chen J, Long Z, Li Y, Luo M, Luo S, He G*. Alteration of the Wnt/GSK3β/β‑catenin
signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model. Int J Mol Med ， 2019 Jul;44(1):313-323. doi: 10.3892/ijmm.2019.4198.
23. Zeng Q#, Long Z#, Feng M, Zhao Y, Luo S, Wang K, Wang Y, Yang G, He G*. Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer's Disease .Front Aging Neurosci. 2019 Mar 26;11:62. doi: 10.3389/fnagi.2019.00062.
24. Yao Q#, Feng M#, Yang B, Zhang W, He G, Wang K*. Effects of estrogen deficiency on senile plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice. ACTA BIOCH BIOPH SIN, 2018 May 1; 50(5):447-455.doi: 10. 1093/abbs/gmy032.
25. Feng J, Wang J, Du Y, Liu Y, Zhang W, Chen J, Liu Y, Zheng M, Wang K, He G*.
Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing
NLRP3 inflammasome activation in APP/PS1 transgenic mice. CNS Neurosci Ther. 2018 Dec;24(12):1207- 1218. doi: 10. 1111/cns.12983. Epub 2018 Jun 4.
26. Qin W, Luo M, Wang K, Yang M, Sheng H, He G*. A combined treatment with erythrocyte lysis solution and Sudan Black B reduces tissue autofluorescence in double-labeling
immunofluorescence. J Microscopy (Oxf). 2018 Dec 1;67(6):345-355. doi: 10. 1093/jmicro/dfy038.
27. Deng Y, Wang J, He G, Qu F, Zheng M. Mobilization of endothelial progenitor cell in patients with acute ischemic stroke. Neurol Sci. 2018 Mar;39(3):437-443
28. Wang LX, Du YH, Wang KJ, Xu G, Luo SF, He G*. Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice. Exp Neurol. 2016
Sep;283(Pt A):353-64. doi: 10. 1016/j.expneurol.2016.07.006.
29. Long Z, Zeng Q, Wang K, Sharma A, He G*. Gender differences of valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mouse models of Alzheimer’s disease, 2016, ACTA BIOCH BIOPH SIN. 2016 Oct;48(10):930-938.
30. Zeng Q, Zheng M, Zhang T, He G*. Hippocampal neurogenesis in the APP/PS1/Nestin-GFP triple transgenic mouse model of Alzheimer’s disease. Neuroscience, 2016 Feb 9, 314: 64-74, doi:10. 1016/j.neuroscience.2015. 11.054
31. Long ZM, Zhao L, Jiang R, Wang KJ, Luo SF, Zheng M, Li XF, He G*. Valproic acid modifies synaptic structure and accelerates neurite outgrowth via the glycogen synthase kinase 3β signaling pathway in an Alzheimer's disease model. CNS Neurosci Ther. 2015 Nov;21(11):887-97. doi: 10. 1111/cns.12445. Epub 2015 Sep 19. (IF:4.06)
32. Chu Y, Peng X, Long Z, Wang K, Luo S, Sharma A, He G*. Acta Biochim Biophys Sin (Shanghai). 2015 Apr;47(4):258-66. doi: 10. 1093/abbs/gmv010. Epub 2015 Mar 2.
33. Long ZM, Zheng M, Zhao L, Xie P, Song C, Chu YL, Song W, He G*. Valproic acid
attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer’s disease mice model. Curr Alzheimer Res. 2013 Mar;10(3):261-9. (PMID:23036022) （IF：3.95）
34. Gao BB, Long ZM, Zhao L, He G*. Effect of normobaric hyperoxia on behavioral deficits and neuropathology in Alzheimer’s Disease mouse model. J. Alzheimer Disease, 2011 ，27: 317-326 Chen B, B
35. romley-Brits K., He G., Cai F., Zhang X., and Song W. Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimer’s Disease Mouse Model. Current Alzheimer’s Disease.2010, 7:255-261
36. He G, Song W. A study on the degradation pathway of Aph- 1 and Nicastrin, two critical components of gamma- secretase complex. J Neurochem, 2009 ，109 ，298-299
37. Qing H#, He G#, Ly PTT#, Fox CJ, Staufenbiel M, Cai F, Zhang Z, Wei S, Sun X, Chen C, Zhou W, Wang K, and Song W Valproic acid inhibits Aβ production, neuritic plaque
formation and behavioral deficits in Alzheimer’s Disease mouse models. J Exp Med. 2008 Nov 24;205(12):2781-9. doi: 10. 1084/jem.20081588. Epub 2008 Oct 27
38. He G, Qing H, Tong Y, Cai F, Ishiura S, and Song W. Degradation of Nicastrin involves both proteasome and lysosome. J.Neurochem, 2007, 101, 982-992 (IF:4.5)
39. He G, Qing H, Cai F, Kwok C, Xu H, Yu G, Berstein A, and Song W. Ubiquitin-proteasome pathway mediates degradation of Aph- 1. J Neurochem, 2006, 99, 1403- 1412
40. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, and Song W. Hypoxia facilitates Alzheimer’s Disease pathogenesis by upregulating BACE1 gene
expression. PNAS, 2006, 103(49), 18727- 18732
41. Sun X, He G, and Song W. BACE2, as a novel APP θ-secrtase is not responsible for Alzheimer’s disease pathogenesis in Down syndrome. FASEB J.,2006,20, 1369- 1376
42. Li Y, Zhou W, Yi G, He G, and Song W. Control of APP processing and Aβgeneration level by BACE1 enzymatic activity and transcription. FASEB J., 2006, 20:285-292
