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College of Laboratory Medicine -- Professor WANG Hong

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PERSONAL INFORMATION

Name: Hong Wang

Gender: femal

Title: Professor

 

CONTACT INFORMATION

Email: wanghongljf@cqmu.edu.cn

Address: Collage of Laboratory Medicine, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing, PR China, Zip code 400016

Phone: +86-68485388

 

EDUCATION EXPERIENCE

Chongqing Medical University , Ph.D in clinical laboratory medicine, Chongqing, (2009 -2012)

Chongqing Medical University,  M.D in clinical laboratory medicine, Chongqing, (2003 -2006)

Chongqing Medical University, B.A  in  clinical laboratory medicine, Chongqing, (1992 -1997)

 

WORKING EXPERIENCE

2004-present  Research work and daily management of Key Laboratory Of  Diagnostic Medicine Designated by the Ministry of Education, CQMU, China

2007-2010 Assisted in undergraduate course of Clinical Laboratory Instruments, CQMU, China

2004-2006 Assisted in undergraduate course of Clinical Hematology, CQMU, China

1997-2003 Assisted in undergraduate course of Laboratory Diagnosis, CQMU, China

 

RESEARCH INTERESTS

Interaction between host immune cells and Streptococcus pneumoniae 

  • Worked on  whether heat shock protein of Streptococcus pneumoniae was involved in bacterial virulence

  • Tested  the strong natural immune reactions elicited by Streptococcus pneumoniae

 

Molecular Diagnose of Mycobacterium Tuberculosis

  • Designed primer of  M. Tuberculosis DNA

  • Established a new real-time PCR assay of M. Tuberculosis

 

HONOUR & AWARDS

Chongqing Science and Technology Awards, Chongqing Science and Technology Committee, 2012 Pathogenic mechanism of Streptococcus pneumonia  

 

PUBLICATIONS

  1. Sijia Cao 1, Xiaoyun Dou 2, Xuemei Zhang , Yuting Fang, Zihan Yang , Yinting Jiang , Xiaoling Hao3, Ziyuan Zhang, Hong Wang. Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.Mol Immunol 2021 Dec;140:87-96. doi: 10.1016/j.molimm.2021.09.011. 

  2. Jiang Y, Liao H, Zhang X, Cao S, Hu X, Yang Z, Fang Y, Wang H. IL-33 synergistically promotes the proliferation of lung cancer cells in vitro by inducing antibacterial peptide LL-37 and proinflammatory cytokines in macrophages.Immunobiology. 2020 Nov 3;225(6):152025. doi: 10.1016/j.imbio.2020.152025.

  3. Hu X, Peng X, Lu C, Zhang X, Gan L, Gao Y, Yang S, Xu W, Wang J, Yin Y, Wang H.Type I IFN Expression is Stimulated by Cytosolic MtDNA Released from Pneumolysin-Damaged Mitochondria Via the STING Signaling Pathway in Macrophages. FEBS J. 2019 Dec;286(23):4754-4768. doi: 10.1111/febs.15001.

  4. Yang S, Yin Y, Xu W, Zhang X, Gao Y, Liao H, Hu X, Wang J, Wang H.Type I interferon induced by DNA of nontypeable Haemophilus influenza modulates inflammatory cytokine profile to promote susceptibility to this bacterium.Int Immunopharmacol. 2019 Sep;74:105710. doi: 10.1016/j.intimp.2019.105710.

  5. Gao Y, Xu W, Dou X, Wang H, Zhang X, Yang S, Liao H, Hu X, Wang H.Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells.Front Microbiol . 2019 Mar 28;10:630. doi: 10.3389/fmicb.2019.00630.

  6. Jin Cui, Chenyu Ma, Guo Ye, Yong Shi, Wenchun Xu, Liang Zhong, Jian Wang, Yibing Yin, Xuemei Zhang, Hong Wang. DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK. Molecular Immunology.2017March;83: 137-146

  7. Dong J, Wang J, He Y, Li C, Zhou A, Cui J, Xu W, Zhong L, Yin Y, Zhang X, Wang H. GHIP in Streptococcus pneumoniae is involved in antibacterial resistance and elicits a strong innate immune response through TLR2 and JNK/p38MAPK. FEBS J. 2014 Sep;281(17):3803-15

 

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