PERSONAL INFORMATION
Name: Jinyong Luo
Gender: Male
Title: Professor
CONTACT INFORMATION
Email: luojinyong@cqmu.edu.cn
Address: College of Laboratory Medicine, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P.R. China
Phone: +86-23-68485240
EDUCATION EXPERIENCE
1994-1999, Chongqing Medical Universtiy, Bachelor.
1999-2002, Chongqing Medical Universtiy, Master.
2005-2008, Chongqing Medical Universtiy, PhD.
WORKING EXPERIENCE
2002-Presnt, Chongqing Medical Universtiy
2016-2018, the University of Chicago
RESEARCH INTERESTS
Our research interests include mesenchymal stem cells and fracture repair, and the identification of anti-tumor natural products
PUBLICATIONS
1. Xiaoxuan Wang, Lijuan Luo, Jingtao Xu, Qiuping Lu, Haichao Xia, Yanran Huang, Lulu Zhang, Liping Xie, Habu Jiwa, Shiqiong Liang, Xiaoji Luo, Jinyong Luo. Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways. Genes & Diseases. 2023;11(2):1050-1065. doi: 10.1016/j.gendis.2023.03.031. eCollection 2024 Mar.
2. Qiuping Lu, Huakun Huang, Xiaoxuan Wang, Lijuan Luo, Haichao Xia, Lulu Zhang, Jingtao Xu, Yanran Huang, Xiaoji Luo, Jinyong Luo. Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways. Pharmacol Res. 2023;191:106760. doi: 10.1016/j.phrs.2023.106760. Online ahead of print. Haichao Xia, Yanran Huang, Lulu Zhang, Lijuan Luo, Xiaoxuan Wang, Qiuping Lu, Jingtao Xu, Chunmei Yang, Habu Jiwa, Shiqiong Liang, Liping Xie, Xiaoji Luo, Jinyong Luo. Inhibition of Macropinocytosis Enhances the Sensitivity of Osteosarcoma Cells to Benzethonium Chloride. Cancers (Basel). 2023;15(3):961.
3. Huakun Huang, Qiuping Lu, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo. TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9. Cell Death Discov. 2022;8(1):499.
4. Huakun Huang, Qiuping Lu, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo. Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways. Chem Biol Interact. 2022;365:110068.
5. Caihong Ye, Mengqi Wei, Huakun Huang, Yuping Wang, Lulu Zhang, Chunmei Yang, Yanran Huang, Jinyong Luo. Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways. Biol Chem. 10;403(10):929-943.
6. Jingtao Xu, Xiaoxuan Wang, Lijuan Luo, Haichao Xia, Qiuping Lu, Yanran Huang, Yuping Wang, Jun Zhang, Habu Jiwa, Runhan Zhao, Chuang Xiong, Jinyong Luo, Xiaoji Luo. Neferine inhibits the growth of human osteosarcoma cells through activating P38/JNK and suppressing Wnt/β-catenin signaling pathway. Journal of Functional Foods. 2022;97:105262.
7. Chunmei Yang, Lulu Zhang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo, Jinyong Luo. Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways. Genes Dis. 2022;9(2): 466-478.
8. Mengqi Wei, CaihongYe, Huakun Huang, ChunmeiYang, Lulu Zhang, Yanran Huang, Yuping Wang, Xiaoji Luo, Jinyong Luo. Acacetin inhibits the tumor growth of human osteosarcoma cells through regulating Wnt/β-catenin and JNK signaling pathways. Journal of Functional Foods. 2022;93:105103.
9. Yuping Wang, Jin Chen, Yanran Huang, Shengdong Yang, Tao Tan, Nan Wang, Jun Zhang, Caihong Ye, Mengqi Wei, Jinyong Luo, Xiaoji Luo. Schisandrin B suppresses osteosarcoma lung metastasis in vivo by inhibiting the activation of the Wnt/β‑catenin and PI3K/Akt signaling pathways. Oncol Rep. 2022;47(3):50.
10. Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yuping Wang, Xiaoji Luo, Jinyong Luo. Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway. Biomed Pharmacother. 2021;134:111155.
11. Ping Zhang, Xiaohui Yuan, Tingting Yu，Huakun Huang, Chunmei Yang, Lulu Zhang, Shengdong Yang, Xiaoji Luo, Jinyong Luo. Lycorine inhibits cell growth, migration, invasion and mainly exerted in vitro cytostatic effects in human colorectal cancer possibly through activating ROS/p38 and AKT pathways. Oncol Rep. 2021;45(4):19.
12. Yanran Huang, Jin Chen, Shengdong Yang, Tao Tan, Nan Wang, Yuping Wang, Lulu Zhang, Chunmei Yang, Huakun Huang, Jinyong Luo, Xiaoji Luo. Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways. Drug Des Devel Ther. 2020;14:4625-4637.
13. Xiao-Hui Yuan, Ping Zhang, Ting-Ting Yu, Hua-Kun Huang, Lu-Lu Zhang, Chun-Mei Yang, Tao Tan, Sheng-Dong Yang, Xiao-Ji Luo, Jin-Yong Luo. Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/β-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway. Am J Transl Res. 2020;12(9): 5381–5398.
14. Shengdong Yang, Jin Chen, Tao Tan, Nan Wang, Yanran Huang, Yuping Wang, Xiaohui Yuan, Ping Zhang, Jinyong Luo, Xiaoji Luo. Evodiamine Exerts Anticancer Effects Against 143B and MG63 Cells Through the Wnt/β-Catenin Signaling Pathway. Cancer Manag Res. 2020;12:2875-2888. Liu X, Ji C, Xu L, Yu T, Dong C, Luo J. Hmox1 promotes osteogenic differentiation at the expense of reduced adipogenic differentiation induced by BMP9 in C3H10T1/2 cells. 2018;119(7):5503-5516.
15. Wang Y, Feng Q, Ji C, Liu X, Li L, Luo J. RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2017;40(6):1991-1999.
16. Ji C, Liu X, Xu L, Yu T, Dong C, Luo J. Runx1 plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12 and MEFs. Int J Mol Sci. 2017;18(7).
17. Zhang H, Li L, Dong Q, Wang Y, Feng Q, Ou X, Zhou P, He T, Luo J. Activation of PKA/CREB Signaling is involved in BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells. Cell Physiol Biochem. 2015;37(2):548-562. Liu Y, Wang W, Xu J, Li L, Dong Q, Shi Q, Zuo G, Zhou L, Weng Y, Tang M, He T, Luo J. Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Oncol Rep. 2013;30(4):1723-1730.
18. Song T, Wang W, Xu J, Zhao D, Dong Q, Li L, Yang X, Duan X, Liang Y, Xiao Y, Wang J, He J, Tang M, Wang J, Luo J. Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2. Int J Biochem Cell Biol. 2013;45(8):1639-1646.
19. Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, Dong Q, Xiao Y, Duan XL, Yang X, Liang YW, Song T, Tang M, Zhao D, Luo JY. Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep. 2013;46(8):422-427.
20. Xu DJ, Zhao YZ, Wang J, He JW, Weng YG, Luo JY. Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. BMB Rep. 2012;45(4):247-252. Luo J, Tang M, Huang J, He BC, Gao JL, Chen L, Zuo GW, Zhang W, Luo Q, Shi Q, Zhang BQ, Bi Y, Luo X, Jiang W, Su Y, Shen J, Kim SH, Huang E, Gao Y, Zhou JZ, Yang K, Luu HH, Pan X, Haydon RC, Deng ZL, He TC. TGFβ/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem. 2010;285(38):29588-29598.
21. Wu N, Zhao Y, Yin Y, Zhang Y, Luo J. Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenicdifferentiation of C3H10T1/2 mesenchymal stem cells. Acta Biochimica et Biophysica Sinica. 2010;42(10):699-708
22. Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nature Protocols. 2007; 2(5): 1236-1247
23. Luo J, Chen J, Deng ZL, Luo X, Song WX, Sharff KA, Tang N, Haydon RC, Luu HH, He TC. Wnt signaling and human diseases: what are the therapeutic implications? Laboratory Investigation. 2007;87(2): 97-103
