PERSONAL INFORMATION
Name: Juan Chen
Gender: Female
Title: Professor
Position: Vice president of College of Laboratory Medicine in Chongqing Medical University; Vice director of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University
CONTACT INFORMATION
Email: chenjuan2014@cqmu.edu.cn
Address: 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P.R.China
Phone: +86-13883874026
EDUCATION EXPERIENCE
1999.09-2004.07: BS, Clinical Medicine, Chongqing Medical University
2004.09-2007.07: MS, infectiology, Chongqing Medical University
2007.09-2011.02: Ph.D, Anatomical and Cellular Pathology, The Chinese University of Hong Kong
WORKING EXPERIENCE
2022.12 to present: Vice president of College of Laboratory Medicine in Chongqing Medical University; Vice director of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University; Professor; Research Fellow
2022.01-2022.12 Vice president of College of Laboratory Medicine in Chongqing Medical University; Vice director of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University; Research Fellow
2021.01-2021.12: Vice director of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University; Research Fellow
2015.11-2020.12: Research Fellow of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University
2011.09-2015.10: Associate Research Fellow of Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) in Chongqing Medical University
RESEARCH INTERESTS
Professor Chen has been engaged in research on the pathogenesis and prevention of hepatitis B, the pathogenesis of NAFLD/virus-associated HCC.
She has been continuously funded by the National Natural Science Foundation of China for seven times including outstanding youth fund project, international cooperation project and four general programs. In addition, she has been in charge of key research and development project of Ministry of Science and Technology.
HONOUR & AWARDS
1. National Natural Science Foundation for young talent
2. Youth Scholars of the Yangtze River, Ministry of Education
3. Young Female Scientist Award in China
4. Youth Science and Technology Award in China
5. National "March 8th" Red Banner
6. The First Prize of Chongqing Natural Science Award
7. The First Prize of Tianjin Science and Technology Progress Award
8. Chongqing elite innovation and entrepreneurship leading talents
9. Chongqing University excellent talent support program a “Ba Yu scholars
PUBLICATIONS
1. Quan-Xin Long*, Xiao-Jun Tang*, Qiu-Lin Shi*, Qin Li*, Hai-Jun Deng*, Jun Yuan, Jie-Li Hu, Wei Xu, Yong Zhang, Fa-Jin Lv, Kun Su, Fan Zhang, Jiang Gong, Bo Wu, Xia-Mao Liu, Jin-Jing Li, Jing-Fu Qiu#, Juan Chen#, Ai-Long Huang#. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine. 2020; 26(8):1200-1204. IF:53.440.
2. Quan-Xin Long*, Bai-Zhong Liu*, Hai-Jun Deng*, Gui-Cheng Wu*, Kun Deng*, Yao-Kai Chen*, Pu Liao, Jing-Fu Qiu, Yong Lin, Xue-Fei Cai, De-Qiang Wang, Yuan Hu, Ji-Hua Ren, Ni Tang, Yin-Yin Xu, Li-Hua Yu, Zhan Mo, Fang Gong , Xiao-Li Zhang, Wen-Guang Tian, Li Hu, Xian-Xiang Zhang, Jiang-Lin Xiang , Hong-Xin Du, Hua-Wen Liu, Chun-Hui Lang, Xiao-He Luo, Shao-Bo Wu, Xiao-Ping Cui, Zheng Zhou, Man-Man Zhu, Jing Wang, Cheng-Jun Xue, Xiao-Feng Li, Li Wang, Zhi-Jie Li, Kun Wang, Chang-Chun Niu, Qing-Jun Yang, Xiao-Jun Tang, Yong Zhang, Xia-Mao Liu, Jin-Jing Li, De-Chun Zhang, Fan Zhang, Ping Liu, Jun Yuan, Qin Li, Jie-Li Hu#, Juan Chen#, Ai-Long Huang#. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nature Medicine. 2020; 26(6): 845-848. IF: 53.440.
3. Sheng-Tao Cheng*, Jie-Li Hu, Ji-Hua Ren, Hai-Bo Yu, Shan Zhong, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Wei-Xian Chen, Hong-Mei Xu, Zhen-Zhen Zhang, Xue-Fei Cai, Yuan Hu, Wen-Lu Zhang, Quan-Xin Long, Fang Ren, Hong-Zhong Zhou, Ai-Long Huang#, Juan Chen#. Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx. Journal of Hepatology. 2021; 74(3):522-534. IF: 30.083.
4. Hong-Zhong Zhou*, Fan Li*, Sheng-Tao Cheng*, Yong Xu*, Hai-Jun Deng, Da-Yong Gu, Jin Wang, Wei-Xian Chen, Yu-Jiao Zhou, Min-Li Yang, Ji-Hua Ren, Lu Zheng#, Ai-Long Huang#, Juan Chen#. DDX17-regulated alternative splicing that produced an oncogenic isoform of PXN-AS1 to promote HCC metastasis. Hepatology. 2022;75(4):847-865. IF: 17.425.
5. Li Zhou*, Ji-Hua Ren*, Sheng-Tao Cheng*, Hong-Mei Xu, Wei-Xian Chen, Da-Peng Chen, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yi Liu, Xue-Fei Cai, Hua Tang, Hai-Bo Yu, Jie-Li Hu, Yuan Hu, Hong-Zhong Zhou, Fang Ren, Lin He, Zhong-Wen Hu, Hui Jiang, Hong-Yan Xu, Ai-Long Huang#, Juan Chen#. A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A. Hepatology. 2019; 69(5):1885-1902. IF: 17.425.
6. Ji-Hua Ren*, Jie-Li Hu, Sheng-Tao Cheng, Hai-Bo Yu, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong-Feng Yang, Ying Huang, Yi Liu, Wei-Xian Chen, Xue-Fei Cai, Hua Tang, Yuan Hu, Wen-Lu Zhang, Xiang Liu, Quan-Xin Long, Li Zhou, Na-Na Tao, Hong-Zhong Zhou, Qiu-Xia Yang, Fang Ren, Lin He, Rui Gong, Ai-Long Huang #, Juan Chen#. SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases. Hepatology. 2018; 68(4):1260-1276. IF: 17.425.
7. Juan Chen*, Anthony W H Chan, Ka-Fai To, Weixian Chen, Zhenzhen Zhang, Jihua Ren, Chunli Song, Yue-Sun Cheung, Paul B S Lai, Suk-Hang Cheng, Margaret H L Ng, Ailong Huang#, Ben C B Ko#. SIRT2 Overexpression in Hepatocellular Carcinoma Mediates Epithelial to Mesenchymal Transition by Protein Kinase B/Glycogen Synthase Kinase-3b/bCatenin Signaling. Hepatology. 2013; 57(6):2287-98. IF: 17.425.
8. Fang Ren*, Junchi Hu, Yongjun Dang, Haijun Den, Jihua Ren, Shengtao Cheng, Ming Ta, Hui Zhang, Xin He, Haibo Yu, Juan Zhang, Zhenzhen Zhang, Weixian Chen, Jieli Hu, Xuefei Cai, Yuan Hu, Ailong Huang, Juan Chen#. J Med Virol. 2023;95(3):e28578. IF: 20.69.
9. Long-Kuan Ran*, Yong Chen*, Zhen-Zhen Zhang*, Na-Na Tao, Ji-Hua Ren, Li Zhou, Hua Tang, Xiang Chen, Ke Chen, Wan-Yu Li, Ai-Long Huang#, Juan Chen#.SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway. Clinical Cancer Research. 2016; 22(13):3372-82. IF: 12.531.
10. Quan-Xin Long *, Yan-Jun Jia*, Xin Wang*, Hai-Jun Deng*, Xiao-Xia Cao*, Jun Yuan, Liang Fang, Xu-Rong Cheng, Chao Luo, An-Ran He, Xiao-Jun Tang, Jie-Li Hu, Yuan Hu, Ni Tang, Xue-Fei Cai, De-Qiang Wang, Jie Hu, Jing-Fu Qiu, Bei-Zhong Liu, Juan Chen#, Ai-Long Huang#. Immune memory in convalescent patients with asymptomatic or mild COVID-19. Cell Discovery. 2021; 7(1): 18. IF: 38.09.
