PERSONAL INFORMATION
Name: Zhengzhou Ying
Gender: Male
Title: Associate Professor
CONTACT INFORMATION
Email: zying@cqmu.edu.cn
Address: No.1 Yixueyuan Road, Yuzhong District, Chongqing
Phone: +86-180-5433-0104
EDUCATION EXPERIENCE
2010-2015, PhD Student, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
2007-2009, Graduate Student, Huazhong Agricultural University, College of Animal Sciences & Technology, Wuhan, China.
2003-2007, Undergraduate Student, College of Life Science & Technology, Huazhong Agricultural University, Wuhan, China.
WORKING EXPERIENCE
2022-present, Associate Professor, Chongqing Medical University, Chongqing, China
2016-2021, Postdoctoral Researcher, MD Anderson Cancer Center, Texas, US
2009-2010, Research Associate, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
RESEARCH INTERESTS
Study of epigentic regulators in B cell activation
The COVID-19 pandemic has caused millions of deaths worldwide, and its course changed people's ways of life. As more and more people get vaccinated against COVID-19, the data sheds light on how the world contains the pandemic, which shows the importance and effectiveness of vaccines on protection to the pandemic. For individuals, B cells which are the center of the humoral immune response, produce the antibodies upon vaccine antigen recognition and binding. Following B cell receptor (BCR) cross-linking by binding of antigen, a complex cascade of signaling molecules transduces the signal from BCR to result in B-cell activation, proliferation and differentiation. And inappopriate B-cell activation may cause hypogammaglobulinemia, autoimmune disease, and lymphoma. Therefore, it's worth studying the regulators involving in B-cell activation, which will aid in understanding autoimmune diseases and lymphomagenesis as well as exploring the potential targets to humoral response regulation, autoimmune diseases and lymphoma treatment.
HONOUR & AWARDS
Sam and Freda Davis Fund Postdoc Fellowship (2019)
The National Scholarship For Ph.D (China) (2012)
PUBLICATIONS
1. Zhengzhou Ying, Taiping Chen. (2023). Mechanisms of DNA Methylation and Demethylation During Mammalian Development. Handbook of Epigenetics (3rd edition). https://doi.org/10.1016/B978-0-323-91909-8.00009-8.
2. Swanand Hardikar#, Zhengzhou Ying#, Yang Zeng, Hongbo Zhao, Bigang Liu, Nicolas Veland, Kevin McBride, Xiaodong Cheng, Taiping Chen. (2020). The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein & Cell. 11(3):214-218. doi:10.1007/s13238-019-00682-w. (Co-first author)
3. Yang Zeng, Ren Ren, Gundeep Kaur, Swanand Hardikar, Zhengzhou Ying, Lance Babcock, Esha Gupta, Xing Zhang, Taiping Chen, and Xiaodong Cheng. (2020). The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes & Development. doi:10.1101/gad.341925.120
4. Mei Mei, Ruidong Zhang, ZhongWei Zhou, Zhengzhou Ying, Jincheng Wang, Han Zhang, Huyong Zheng and Shilai Bao. (2019). PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia. Clinical Cancer Research. 25(8):2633-2643; doi: 10.1158/1078-0432.CCR-18-2342
5. Zhengzhou Ying, Taiping Chen. (2018). Cross Talk Between Noncoding RNAs and DNA Methylation and Demethylation in Cancer. Cancer and Noncoding RNAs. 10.1016/B978-0-12-811022-5.00017-6.
6. Chunyi Liu, Mei Mei, Qiuling Li, Peristera Roboti, Qianqian Pang, Zhengzhou Ying, Fei Gao, Martin Lowe, Shilai Bao. (2017). Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice. Proceedings of the National Academy of Sciences. 114 (2):346-351.
7. Zhengzhou Ying, Mei Mei, Peizhun Zhang, Chunyi Liu, Huacheng He, Fei Gao and Shilai Bao (2015). Histone arginine methylation by PRMT7 controls germinal center formation via regulating Bcl6 transcription. Journal of Immunology. 195(4):1538-47; doi: 10.4049/jimmunol.1500224.
8. Jing Zhang#, Zheng-zhou Ying#, Zhong-lin Tang, Liang-qi Long and Kui Li. (2012). MicroRNA-148a Promotes Myogenic Differentiation by Targeting the ROCK1 Gene. Journal of Biological Chemistry. 287(25):21093~21101; doi: 10.1074/jbc.M111.330381 (Co-first author)
