PERSONAL INFORMATION
Name: Mingwei Liu (Spencer liu)
Gender: Male
Title: Ph. Dr & Associate professor
Position: Head of the Teaching and Research Section,
Executive Director of Chongqing Bioinformatics Society
CONTACT INFORMATION
Website: https://mlab.liumwei.org
ORCD: https://www.researchgate.net/profile/Mingwei-Liu-3
Email: liumingwei@cqmu.edu.cn
Address: No.1, Yiyuanyuan Road, Yuzhong District, Chongqing, PRC. China
Phone: +86-68485240
EDUCATION EXPERIENCE
1997.9-2001.7, Bachelor in Biotechnology from Agricultural College of Sichuan Agricultural University
2001.9-2006.7, Ph.D. in Biochemistry and Molecular Biology, School of Agriculture, Sichuan Agricultural University
2010.10-2011.10, Visiting Scholar, Research Center for Shanghai Bioinformation Technology
WORKING EXPERIENCE
2007-present, teacher and researcher at Chongqing Medical University.
2015-present, tutor and supervisor for undergraduates on the innovation and entrepreneurship.
2016-present, researcher and practitioner of education informatization by Open-source technology.
2016-present, advisor for masters on clinical laboratory diagnostics and medical technology.
RESEARCH INTERESTS
Oncological Bioinformatics and Clinical Translation, including identification of tumor biomarkers with corroborative semantic knowledge and omics data analysis in the context of clinical data, insights into molecular immunotherapy, as well as the deep investigation of the relationship between tumor genes, expression variations, molecular typing, molecular mechanisms, function networks, tumorigenesis, cancer developments, and clinical phenotypes.
l Robust analysis methods and strategies for omics data
l Characteristics and models of tumor microenvironment and immune ecological network
l exosome-derived biomarkers for tumor liquid biopsy diagnostic and therape.
Medical laboratory artificial intelligence (AI), focusing on AI-assisted processing and mining for test panels and disease diagnosis models, and AI-assisted cell morphology.
l Intelligent POCT and Data Applications
l Semantic Biology and Biomarker Ontology
l Tumor knowledge graph and omics knowledge
l AI-assisted morphology of blood and bone cells
l AI-assisted analysis of tangible components (sperm, vagina, thin layer cells, feces)
l AI-assisted diagnosis of smear diseases (blood, bone marrow)
HONOUR & AWARDS
2023-2025, Future Medical Youth Innovation Team of Chongqing Medical University, (Deputy Team Leader)
2018-2021, Construction and Multi field Application of Shared Big Data Artificial Intelligence Diagnosis Platform. Natural Science Foundation of Chongqing Municipal Science and Technology Commission Foundation: NO. cstc2018jscx mszdX0022 (The Main Executor)
2018-2021, Research and Application of an Integrated Technology for Nucleic Acid Preprocessing. Natural Science Foundation of Chongqing Municipal Science and Technology Commission: NO. cstc2018jscx-msybX0010 (The Main Executor)
2016-2019, Accurate and Rapid Detection Method for SNPs Based on UDG-mediated PCR, Magnetic Nanoenrichment, and Chain Displacement Reaction. National Science Foundation of China (NSFC): NO. 81672112 (The Main Executor)
2015-2018, A Novel Mineralized Nanoprotein Vaccine Against Streptococcus pneumoniae: Construction, Thermal Stability, and Immunoprotective Effects of the Vaccine. National Science Foundation of China (NSFC): NO. 81571622 (The Main Executor)
2012-2015, Research on the Mechanism of Neutrophil Extracellular Traps (NETs) in Treating Pneumococcal Otitis Media. Natural Science Foundation of Chongqing Municipal Science and Technology Commission Foundation: NO.cstc2012jjA10014 (The Main Executor)
2015-2017, Research on the Construction Technology Platform of Online Course Content Based on HTML5 Rich Media Interaction Technology. Chongqing Medical University Teaching and Reforming Foundation: NO. JY150203 (The Principal)
2012-2015, Genomics and Bioinformatics-based Study on Virulence Factor Variability and Virulome of Multiple Serotypes of Streptococcus pneumoniae, Chongqing Municipal Science and Technology Commission Foundation: NO: cstc2012jjA0016 (The Principal)
2007-2009, Construction and Development of Rapid Deployment System, BioInfoServOS for the Bioinformation Platform. Chongqing Medical University: NO. XBYB2007103 (The Principal)
2011-2014, Chongqing Municipal Commission of Science and Technology General Project: High throughput screening of antibacterial traditional Chinese medicine lead compounds targeting YycG protein in the TCS system, NO. cstc2011jjA10063 (The Main Executor)
2009-2010, Chongqing Medical University: Research and development of a three-dimensional virtual simulation system for urine analyzer. Chongqing Medical University Teaching and Reforming Foundation (The Main Executor)
PUBLICATIONS
Fei Long†, Haodong Ma†, Youjin Hao†, Luyao Tian, Yinghong Li, Bo Li, Juan Chen, Ying Tang, Jing Li, Lili Deng, Guoming Xie* and Mingwei Liu* (2023) . A novel exosome-derived prognostic signature and risk stratification for breast cancer based on multi-omics and systematic biological heterogeneity. Computational and Structural Biotechnology Journal, 21:3010-3023. (doi: 10.1016/j.csbj.2023.05.013, IF 6.0, Q2;).
Luyao Tian†, Fei Long†, Youjin Hao, Bo Li, Yinghong Li, Ying Tang, Jing Li, Qi Zhao, Juan Chen* and Mingwei Liu* (2022). A Cancer Associated Fibroblasts-Related Six-Gene Panel for Anti-PD-1 Therapy in Melanoma Driven by Weighted Correlation Network Analysis and Supervised Machine Learning. Frontiers in Medicine, 1024 (IF 5.058, Q3;).
Fei Long†, Luyao Tian†, Zixuan Chai, Jing Li, Ying Tang and Mingwei Liu* (2022). Identification of stage-associated exosome miRNAs in colorectal cancer by improved robust and corroborative approach embedded miRNA-target network. Frontiers in Medicine, 2904 (IF 5.058, Q3; ).
Xuanyi Wang†, Zixuan Chai†, Guizhi Pan†, Youjin Hao, Bo Li, Ting Ye, Yinghong Li, Fei Long, Lixin Xia* and Mingwei Liu* (2021). ExoBCD: a comprehensive database for exosomal biomarker discovery in breast cancer. (doi: 10.1093/bib/bbaa088; IF 13.994, Q1; )
Xuanyi Wang†, Zixuan Chai†, Yinghong Li, Fei Long, Youjin Hao, Guizhi Pan, Mingwei Liu* and Bo Li* (2020), Identification of potential biomarkers for anti-PD-1 therapy in melanoma by weighted correlation network analysis[J]. Genes, 11(4), 435. (doi:10.3390/genes11040435; IF: 4.141, Q2;).
Yafei Wu†, Tao Song†, Mingwei Liu†, Qingling He, Lei Chen, Yamin Liu, Dongsheng Ni, Jianing Liu, Yanxia Hu, Yuping Gu, Qianyin Li, Qin Zhou* and Yajun Xie* (2019). PPARG negatively modulates Six2 in tumor formation of clear cell renal cell carcinoma. DNA and cell biology, 38(7), 700-707(doi: 10.1089/dna.2018.4549, IF: 3.550, Q2;).
