PERSONAL INFORMATION
Name: Zhou Lan
Gender: Female
Nationality: P.R.China
CONTACT INFORMATION
Email: zhoulan@cqmu.edu.cn or zhoulan0111@foxmail.com
EDUCATION EXPERIENCE
1979.9-1984.8 M.D. (Diploma in Medicine), School of Medicine, Chongqing Medical University, Chongqing, China 400016
1986.9-1989.7 M.S. in Pathophysiology, Department of Pathophysiology, Chongqing Medical University, Chongqing, China 400016
1994.9-1997.7 Ph.D. in Clinical Laboratory Diagnostics, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China, 400016
WORKING EXPERIENCE
1984-1986: Resident and Chief Resident, The Tuberculosis Prevention and Treatment Center, Sichuan Academy of Medical Sciences, P. R. China.
1989-1997: Assistant Professor /lecturer, Department of Pathophysiology, School of Basic Medical Sciences, Chongqing Medical University
1997-2000: Associate Professor and Chairman, Department of Molecular Biology, School of Basic Medical Sciences, Chongqing Medical University
2000-2003: Research Associate, Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center
2003-2007: Professor of Molecular Biology, College of Biomedical Engineering, Chongqing Medical University
2007-10-present: Professor of Molecular Biology, Key Laboratory of Diagnostic Medicine (Designated by Ministry of Education), College of Laboratory Medicine, Chongqing Medical University
RESEARCH INTERESTS
1.The interactions and molecular mechanisms among S100 family members, colorectal carcinoma and other tumors
2.The relationships and molecular mechanisms among Fusobacterium nucleatum, Macrophage, Neutrophil extracellular traps and their effects on colorectal carcinoma progression
HONORS AWARDS
Recipient of Outstanding young and middle-aged backbone teachers in Chongqing colleges and universities, given by the Ministry of the Higher Education of Chongqing Municipality, P.R. China, 2004.
Received the National Second Place Award for Scientific and Technological Advancement, awarded by the Ministry of Public Health, P.R. China in 1993.
Received the Provincial Second Place Prize for Scientific and Technological Advancement, awarded by Sichuan Provincial Government, P. R. China in 1990.
PUBLICATION
1. Xuehua Kong†, Yu Zhang†, Linwei Xiang†, Yan You , Yaqian Duan , Yuqing Zhao , Shue Li , Rui Wu , Jiangbo Zhang , Lan Zhou* and Liang Duan* Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression J Exp Clin Cancer Res 2023;
DOI 10.1186/s13046-023-02817-8
2.Yan Liu †, Xuehua Kong †, Yan You , Linwei Xiang , Yan Zhang , Rui Wu , Lan Zhou * and Liang Duan * S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis
in Macrophages Facilitates Liver Fibrosis Progression Cells 2022, 11, 3579. doi:10.3390/cells11223579
3.Lijun Hu†,Yan Liu†,Xuehua Kong, Rui Wu, Qi Peng,Yan Zhang,Lan Zhou*,Liang Duan* Fusobacterium nucleatum Facilitates M2 Macrophage Polarization and Colorectal Carcinoma Progression by Activating TLR4/NF-kB/S100A9 Cascade
Frontiers in Immunology 2021; Vol.12:658681 doi: 10.3389/fimmu. 2021.658681
4. Qi Peng, Yan Liu, Xuehua Kong, Jie Xian, Lin Ye, Li Yang, Shuliang Guo, Yan Zhang , Lan Zhou* and Tingxiu Xiang* The Novel Methylation Biomarker SCARA5 Sensitizes Cancer Cells to DNA Damage Chemotherapy Drugs in NSCLC Front Oncol. 2021 Jun 4;11:666589. doi: 10.3389/fonc.2021.666589. eCollection 2021.PMID: 34150631
5. Qin Hu, Feifei Zhang, Liang Duan, Bo Wang, Yuanyuan Ye, Pu Li, Dandan Li, Shengjun Yang, Lan Zhou* and Weixian Chen*. E-cadherin plays a role in hepatitis B virus entry through affecting glycosylated sodium-taurocholate cotransporting polypeptide distribution[J]. Frontier in cellular and infection microbiology. 2020, 10(74):1-13
6. Mao Huang †, Rui Wu †,Lu Chen, Qi Peng, Shue Li,Yan Zhang, Lan Zhou*, Liang Duan* S100A9 regulates MDSCs-mediated immune suppression via RAGE andTLR4 signalling pathways in colorectal carcinoma Frontiers in Immunology 2019；10: 2243
doi: 10.3389/fimmu.2019.02243
7. Aifang Li, Yue Gu, Xueru Li, Hui Sun, He Zha, Jiaqing Xie, Jiali Zhao, Mao Huang, Lu Chen, Qi Peng, Yan Zhang, Yaguang Weng and Lan Zhou*. S100A6 promotes the proliferation and migration of cervical cancer cells via the PI3K/Akt signaling pathway ONCOLOGY LETTERS 2018;15: 5685-5693 DOI: 10.3892/ol.2018.8018
8. Zha H, Sun H, Li X, Duan L, Li A, Gu Y, Zeng Z, Zhao J, Xie J, Yuan S, Li H, Zhou L*. S100A8 facilitates the migration of colorectal cancer cells through regulating macrophages in the inflammatory microenvironment. Oncol Rep. 2016 ;36(1):279-90. doi: 10.3892/or.2016.4790
9. Duan L, Ye L, Wu R, Wang H, Li X, Li H, Yuan S, Zha H, Sun H, Zhang Y, Chen X, Zhang Y, Zhou L* Inactivation of the phosphatidylinositol 3-kinase/Akt pathway is involved in BMP9-mediated tumor-suppressive effects in gastric cancer cells J Cell Biochem. 2015; 116: 1080–1089
10. Liang Duan, Rui Wu, Zhengyu Zou, Haiyan Wang, Liwei Ye, Huan Li, Shimei Yuan,Xueru Li, He Zha, Hui Sun, Yunyuan Zhang, Xian Chen and Lan Zhou* S100A6 stimulates proliferation and migration of colorectal carcinoma cells through activation of the MAPK pathways International Journal of Oncology 2014；44：781-90
