PERSONAL INFORMATION
Name: Zhang Ling
Gender: Female
Title: Professor
Position: Director, Department of Clinical Hematology
CONTACT INFORMATION
Email: lingzhang@cqmu.edu.cn
Address: 1# Medical Road, Daping, Chongqing China, 400016
Phone: +86-131 0123 2499
EDUCATION EXPERIENCE
1988.9-1993.7 Laboratory Medicine, B.Sc., Chongqing Medical University
1995.9-1998.7 Laboratory Medicine, M.D., Chongqing Medical University
2001.9-2004.7 Laboratory Medicine, Ph.D., Chongqing Medical University
WORKING EXPERIENCE
2010.12-present: Professor, Key laboratory of Laboratory Medical Diagnostics (Ministry of Education), and College of Laboratory Medicine, Chongqing Medical University.
2011.9-2012.9: Visiting Scientist at The University of Texas MD Anderson Cancer Center in the Department of Molecular & Cellular Oncology, Division of Basic Science Research.
2003.11-2010.11: Associate professor, College of Laboratory Medicine, Chongqing Medical University.
1998.7-2003.10: Lecturer, College of Laboratory Medicine, Chongqing Medical University.
RESEARCH INTERESTS
Prof. Zhang has been engaged in research on the pathogenesis and clinical diagnosis of acute myeloid leukemia (AML) for 20 years. She has undertaken 4 projects of National Natural Science Foundations of China and 4 projects of Chongqing Natural Science Foundation of China. The main research interest of Prof. Zhang is acute myeloid leukemia with nucleophosmin (NPM1) mutations. The research team has focused on the role of NPM1 gene mutations in the biological characteristics of leukemic cells, the mechanisms of immune escape in NPM1-mutated AML, and the new therapeutic strategies aimed at improving immune cell activity in AML.
HONOUR & AWARDS
1. Distinguished professor of Chongqing Medical University, 2021
2. “Qian De”Famous Teacher Award of Chongqing Medical University, 2023
PUBLICATIONS
1. Meixi Peng, Jun Ren, Yipei Jing, Xueke Jiang, Qiaoling Xiao, Junpeng Huang, Yonghong Tao, Li Lei, Xin Wang, Zailin Yang, Zesong Yang, Qian Zhan, Can Lin, Guoxiang Jin, Xian Zhang, Ling Zhang*. Tumour-derived small extracellular vesicles suppress CD8+ T cell immune function by inhibiting SLC6A8-mediated creatine import in NPM1-mutated acute myeloid leukaemia. J Extracell Vesicles. 2021 Nov;10(13):e12168.
2. Yipei Jing #, Xueke Jiang # , Li Lei , Meixi Peng, Jun Ren, Qiaoling Xiao, Yao Tao, Yonghong Tao, Junpeng Huang, Lu Wang, Yuting Tang, Zailin Yang, Zesong Yang, Ling Zhang*. Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3. J Exp Clin Cancer Res. 2021 Oct 6;40(1):312. doi: 10.1186/s13046-021-02122-2.
3. Zou Q, Tan S, Yang Z, Zhan Q, Jin H, Xian J, Zhang S, Yang L, Wang L, Zhang L*. NPM1 mutant mediated PML delocalization and stabilization enhances autophagy and cell survival in leukemic cells. Theranostics. 2017; 7(8): 2289-2304.
4. Jun Ren #, Yonghong Tao #, Meixi Peng, Qiaoling Xiao, Yipei Jing, Junpeng Huang, Jing Yang, Can Lin, Minghui Sun, Li Lei, Zesong Yang, Zailin Yang, Ling Zhang*. Targeted activation of GPER enhances the efficacy of venetoclax by boosting leukemic pyroptosis and CD8+ T cell immune function in acute myeloid leukemia. Cell Death Dis. 2022 Oct 31;13(10):915. doi: 10.1038/s41419-022-05357-9.
5. Junpeng Huang#, Minghui Sun# , Yonghong Tao, Jun Ren , Meixi Peng, Yipei Jing, Qiaoling Xiao, Jing Yang, Can Lin, Li Lei, Zailin Yang, Ling Zhang*. Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells. Int J Mol Sci.2023 Jan 13;24(2):1624.
6. Yuting Tang, Yao Tao, Lu Wang, Liyuan Yang, Yipei Jing, Xueke Jiang, Li Lei, Zailin Yang, Xin Wang, Meixi Peng, Qiaoling Xiao, Jun Ren, Ling Zhang*. NPM1 mutant maintains ULK1 protein stability via TRAF6-dependent ubiquitination to promote autophagic cell survival in leukemia. FASEB J. 2021 Feb;35(2):e21192. doi: 10.1096/fj.201903183RRR.
7. Tao Y, Tang Y, Yang Z, Wu F, Wang L, Yang L, Lei L, Jing Y, Jiang X, Jin H, Bai Y, Zhang L*. Exploration of serum exosomal lncRNA TBILA and AGAP2-AS1 as promising biomarkers for diagnosis of non-small cell lung cancer. Int J Biol Sci. 2020;16(3):471-482.
8. Jin H, Yang L, Wang L, Yang Z, Zhan Q, Tao Y, Zou Q, Tang Y, Xian J, Zhang S, Jing Y, Zhang L*. INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia. J Exp Clin Cancer Res. 2018; 37(1):8. doi: 10.1186/s13046-018-0675-9.
9. Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai F, Tsai CH, Watabe K, Lin HK. TRAF6 restricts p53 mitochondrial translocation, apoptosis, and tumor suppression. Mol Cell. 2016;64(4): 803-814.
10. Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan Z, Khanna KK, Jin J, Zeng YX, Lin HK. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell, 2012; 46(3):351-361.
