PERSONAL INFORMATION
Name：Xu Wenchun
Gender：Female
CONTACT INFORMATION
Email：xuwen@cqmu.edu.cn
EDUCATION EXPERIENCE
2004.9-2007.9 Ph.D., Biomedical Engineering, Chongqing Medical University
1991.9-1994.7 MS, Clinical Laboratory Diagnostics, Chongqing Medical University
1984.9-1989.7 BS, Clinical Laboratory Diagnostics, Chongqing Medical University
WORKING EXPERIENCE
2010.10 to present Professor, School of Laboratory Medicine, Chongqing Medical University
2003.10-2010.10 Associate professor, School of Laboratory Medicine, Chongqing Medical University
1994.11-2003.10 Lecturer, School of Laboratory Medicine, Chongqing Medical University
RESEARCH INTERESTS
Prof. Xu has been committed to the pathogenesis, prevention and treatment of allergic asthma, disease markers and detection methods. She undertook 3 projects of National Natural Science Foundation, 1 sub-project of 863 pre-research project, and 5 provincial and ministerial projects. She has published more than 50 academic papers, including more than 20 SCI papers, as the first researcher and corresponding author. She is a reviewer for the Vaccine, Journal of asthma and allergy, and also a communications reviewer for the National Natural Science Foundation of China and an academic dissertation reviewer for the Ministry of Education.
PUBLICATIONS (recent 5 years)
1. Zhang Y, Gao S, Yao S, Weng D, Wang Y, Huang Q, Zhang X, Wang H, Xu W. IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells. iScience. 2023 Jul 25;26(8):107464
2. Huang Q, Weng D, Yao S, Shen H, Gao S, Zhang Y, Huang W, Wang Y, Wang H, Xu W* Progranulin deficiency suppresses allergic asthma and enhances efferocytosis via PPAR-γ/MFG-E8 regulation in macrophages. Immun Inflamm Dis 2023 Feb;11(2): e779
3. Danlin Weng#, Song Gao#, Hailan Shen, Shifei Yao, Qi Huang, Yanyu Zhang, Wenjie Huang, Yan Wang, Xuemei Zhang, Yibing Yin, Wenchun Xu*. CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2. Immunology, 2022 Nov;167(3):384-39
4. Liu C#, Ren L#, Li X, Fan N, Chen J, Zhang D, Yang W, Ding S, Xu W*, Min X*. Self-electrochemiluminescence biosensor based on CRISPR/Cas12a and PdCuBP@luminol nanoemitter for highly sensitive detection of cytochromec oxidase subunit III gene of acute kidney injury. Biosens Bioelectron. 2022 Jul 01; 207:114207
5. Qi Y, Liu C, Zhong X, Ma X, Zhou J, Shi Y, Yin Y, Zhang X, He Y*, Xu W*. IL-27 as a potential biomarker for distinguishing between necrotising enterocolitis and highly suspected early-onset food protein-induced enterocolitis syndrome with abdominal gas signs. EBioMedicine. 2021 Oct 7;72:103607
6. Chen X#, Yang J#, Shen H, Zhang X, Wang H, Wu G, Qi Y, Wang L, Xu W*. Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma. J Asthma Allergy. 2021 Aug 14;14:1033-1043
7. Changjin Liu, Wei Yang, Xun Min, Decai Zhang, Xuhuai Fu, Shijia Ding, Wenchun Xu*. An enzyme-free electrochemical immunosensor based on quaternary metallic/nonmetallic PdPtBP alloy mesoporous nanoparticles/MXene and conductive CuCl 2 nanowires for ultrasensitive assay of kidney injury molecule-1. Sensors and Actuators: B. Chemical
8. Wu G#, Zhang X#, Chen X, Wang J, Yang J, Wang L, Sun S, Qi Y, Wang H, Yin Y, Xu W*. Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type-2 airway inflammation in murine allergic asthma. Br J Pharmacol. 2020 Nov;177(22):5063-5077
9. Wang L, Zhang X, Wu G, Qi Y, Zhang J, Yang J, Wang H, Xu W*.Streptococcus pneumoniae aminopeptidase N contributes to bacterial virulence and elicits a strong innate immune response through MAPK and PI3K/AKT signaling. J Microbiol. 2020 Apr;58(4):330-339
10. Yan J, Zhang X, Sun S, Yang T, Yang J, Wu G, Qiu Y, Yin Y, Xu W*. miR-29b Reverses T helper 1 cells/T helper 2 cells Imbalance and Alleviates Airway Eosinophils Recruitment in OVA-Induced Murine Asthma by Targeting Inducible Co-Stimulator. Int Arch Allergy Immunol. 2019, 180(3): 182-19
11. Yang J#, Wang J#, Zhang X, Qiu Y, Yan J, Sun S, He Y, Yin Y, Xu W*. Mast cell degranulation impairs pneumococcus clearance in mice via IL-6 dependent and TNF-α independent mechanisms.World Allergy Organ J. 2019 Apr 20;12(4):100028
12. Gao Y#, Xu W#, Dou X, Wang H, Zhang X, Yang S, Liao H, Hu X, Wang H. Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells. Front Microbiol. 2019 Mar 28;10:630
13. Zhang X#, Cui J#, Wu Y, Wang H, Wang J, Qiu Y, MoY, He Y, Zhang X, Yin Y and Xu W*. Streptococcus pneumoniae attenuated strain SPY1 with an artifcial Mineral shell induces humoral and Th17 cellular immunity and Protects Mice against Pneumococcal infection. Frontiers in immunology, 2018 Jan 11;8:198
14. Wu J#, Wu K#, Xu W, Yuan T, Wang X, Zhang J, Min Y, Yin Y, Zhang X. Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models. Biomaterials. 2018 Feb;155:152-16
