PERSONAL INFORMATION
Name: Xie Guoming
Gender: Male
CONTACT INFORMATION
Email: guomingxie@cqmu.edu.cn
Address: Chongqing, China
Phone: +86-15803091827
EDUCATION EXPERIENCE
1985.09-1989.07 BS, Biomedical Electronics, Chongqing University
1994.09-1997.07 MS, Biomedical Engineering and Instrumentation, Chongqing University
WORKING EXPERIENCE
1997.08-2012.11 Lecturer, Associate Professor and Professor, Teaching and Research Office of Clinical Laboratory Instruments, Chongqing Medical University
2012.12-2013.06 Visiting Scholar, Department of ECE, University of Nevada, Las Vegas, USA
2013.07-2013.11 Visiting Scholar, Department of Chemistry, University of Illinois at Urbana-Champaign, USA,
2013.12-2021.10 Director, Teaching and Research Office of Clinical Laboratory Instruments, Chongqing Medical University
2021.11 -present Deputy Director, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University
RESEARCH INTERESTS
1.Nanobiological Sensing Research. Faced with the urgent need for rapid and minimally invasive or non-invasive detection of major diseases and infectious diseases, Professor Xie's team integrates various disciplines such as modern molecular diagnostics, immunology, biochemistry, optics, and bioinformatics to develop biosensors for meeting the needs of clinical medicine's fast diagnostics. This has significant scientific significance for the development of new methods and technologies for tissue, cellular, and molecular-level testing.
2. Microfluidic Chip and Detection System Research. Professor Xie's team is focused on designing and constructing multifunctional microarray chips, molecular probes, cell sensors, and DNA sensors. Their expertise lies in signal processing, software design, and instrument miniaturization. Their aim is to promote the development of precision medicine and real-time diagnostics in the field.
HONOUR & AWARDS
1. Outstanding postgraduate tutor of Chongqing Medical University, 2012
2. Third Prize of Chongqing Excellent Teaching Achievement Award, 2013
3. The Third Prize of Chongqing Scientific and Technological Progress Award, 2021
4. Outstanding Communist Party Member of Chongqing Medical University, 2022
PUBLICATIONS
1. Zhao, R.; Luo, W.; Wu, Y.; Zhang, L.; Liu, X.; Li, J.; Yang, Y.; Wang, L.; Wang, L.; Han, X.; Wang, Z.; Zhang, J.; Lv, K.*; Chen, T.*; Xie, G.*, Unmodificated stepless regulation of CRISPR/Cas12a multi-performance. Nucleic acids research 2023, https://doi.org/10.1093/nar/gkad748.
2. Luo, W.; Wu, Y.; Chen, X.; Zhang, L.; Wang, L.; Bai, D.; Liu, Q.; Wang, T.; Yu, H.; Xie Y.; Fu Y.; Wang Z.; Yang, Y.; Li, J.; Guo, Y.*; Lv, K.*; Xie, G.*, Two-point-one-line modularized strategy combined with Holliday-junction button probes for multiloci SNPs long-range distribution analysis. Chemical Engineering Journal 2023, 146026.
3. Zhang, Z.; Guan, L.; Yao, J.; Li, L.; Liu, C.; Guo, Y.*; Xie, G.*, RART-LAMP: One-Step Extraction-Free Method for Genotyping within 40 min. Analytical chemistry 2023, 95 (33), 12487-12496.
4. Yu, H.; Weng, Z.; Zhou, X.; Bai, D.; Luo, W.; Han, X.; Song, L.; Liu, Q.; Li, J.; Yang, Y.; Guo, Y.*; Lv, K.*; Xie, G.*, A hairpin probe-mediated exponential amplification reaction for highly sensitive and specific detection of microRNAs. Chemical communications (Cambridge, England) 2023, 59 (28), 4158-4161.
5. Bai, S.; Xu, B.; Wu, J.; Xie, G.*, Series or parallel toehold-mediated strand displacement and its application in circular RNA detection and logic gates. Biosensors & bioelectronics 2023, 241, 115677.
6. Wu, Y.; Luo, W.; Weng, Z.; Guo, Y.; Yu, H.; Zhao, R.; Zhang, L.; Zhao, J.; Bai, D.; Zhou, X.; Song, L.; Chen, K.; Li, J. *; Yang, Y. *; Xie, G. *, A PAM-free CRISPR/Cas12a ultra-specific activation mode based on toehold-mediated strand displacement and branch migration. Nucleic acids research 2022, 50 (20), 11727-11737.
7. Weng, Z.; Yu, H.; Luo, W.; Guo, Y.; Liu, Q.; Zhang, L.; Zhang, Z.; Wang, T.; Dai, L.; Zhou, X.; Han, X.; Wang, L.; Li, J.*; Yang, Y.*; Xie, G.*, Cooperative Branch Migration: A Mechanism for Flexible Control of DNA Strand Displacement. ACS nano 2022, 16 (2), 3135-3144.
8. Bai, D.; Zhou, X.; Luo, W.; Yu, H.; Bai, S.; Wu, Y.; Song, L.; Chen, K.; Xie, Y.; Chen, X.; Zhao, J.; Fu, Y.; Yang, Y.*; Li, J.*; Xie, G.*, Cooperative strand displacement circuit with dual-toehold and bulge-loop structure for single-nucleotide variations discrimination. Biosensors & bioelectronics 2022, 216, 114677.
9. He, X.; Yang, Y.; Guo, Y.; Lu, S.; Du, Y.; Li, J. J.; Zhang, X.; Leung, N. L. C.; Zhao, Z.; Niu, G.; Yang, S.; Weng, Z.; Kwok, R. T. K.; Lam, J. W. Y.; Xie, G.*; Tang, B. Z.*, Phage-Guided Targeting, Discriminative Imaging, and Synergistic Killing of Bacteria by AIE Bioconjugates. Journal of the American Chemical Society 2020, 142 (8), 3959-3969.
10. Bai, S.; Xu, B.; Guo, Y.; Qiu, J.; Yu, W.; Xie, G.*, High-Discrimination Factor Nanosensor Based on Tetrahedral DNA Nanostructures and Gold Nanoparticles for Detection of MiRNA-21 in Live Cells. Theranostics 2018, 8 (9), 2424-2434.
