PERSONAL INFORMATION
Name: Xiangjun ZHANG
Gender: Male
Title: PhD
Position: Associate Prof.
CONTACT INFORMATION
Email: xiangjunzhang@cqmu.edu.cn
Address: Chongqing Medical University
Phone: 023-68485161
EDUCATION EXPERIENCE
University of Macau |
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PhD degree in biomedical science, 2016.08-2020.12 |
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Third Military Medical University |
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Master degree in Pharmaceutics, 2013.09-2016.07 |
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Shandong University of Traditional Chinese Medicine |
Bachelor of Science in cultivation and identification of Chinese herbal medicines, 2007.09-2011.07 |
WORKING EXPERIENCE
Chong Qing Medical University (2021.3-present) |
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Work involves pharmaceutical application of supramolecular host compounds, in vivo fate of nanodrugs and pharmaceutical research of medicine for children. |
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University of Macau, Institute of Chinese Medical Sciences (2016.8-2020.12) Supervisor: Ruibing Wang |
·Developing specific antidotes based on host-guest chemistry. ·Developing personalized cancer vaccine based on surface protein on cell membrane. ·Developing drug delivery systems based on supramolecular host compounds. Work involves synthesis of host molecules, characterization of host-guest chemistry, decoration of host molecules, fabrication and characterization of nanoparticles, cellular experiments, pharmacokinetics, biocompatibility in mice model, antidotal effects in mice, personalized cancer vaccine preparation, antitumor immune response evaluation in vitro and in vivo, therapeutic efficacy evaluation in mice, gallstone model establishment and anti-cholelithiasis efficacy evaluation. |
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Third Military Medical University, Department of Pharmaceutics (2013.3-2016.6) Supervisor: Jianxiang Zhang |
·Developing an orally drug delivery system using Yeast as carriers for ultimate targeting atherosclerotic lesions. ·Developing the reactive oxygen species (ROS) and pH responsive nanoparticles as drug delivery vehicles for therapy of atherosclerosis and tumor. ·Constructing a rapamycin loaded self-assembly microsphere mediated by a carboxyl-bearing compound and poly(N-isopropylacrylamide) and demonstrated its effectiveness of treating atherosclerosis by oral route. ·Work involves fabrication and characterization of nanoparticles, biocompatibility evaluation if nanoparticles in cellular model, cellular uptake of nanoparticles, biocompatibility evaluation of drugs in mice model, pharmacokinetics study, tissue-organ imaging, distribution of nanoparticles in organs and cells, anti-atherosclerosis, and anti-tumor evaluation. |
Jinan Bestcomm Pharmaceutical R&D Co., Ltd (2011.4-2012.4) Pharmaceutical researcher |
Focus was on the development of generic drug products of solid oral dosage forms. Work involves formulation development, tablets and capsules preparation, scale-up of manufacturing process, control of dissolution and stability of products. |
RESEARCH INTERESTS
1. New Pharmaceutical Excipients based on supramolecular host compounds
2. New drug delivery systems for treatment of resistant bacterial infection
HONOUR & AWARDS
Excellent Master Degree Thesis of People’s Liberation Army of China, 2017 |
Excellent Master Degree Thesis of Chongqing city, 2017 |
Excellent Master Degree Thesis of Third Military Medical University,2016 |
Scholarship for Excellent Freshman (Exemption of the tuition fee, 2013-2015) |
PUBLICATIONS
1. Xiangjun Zhang, Xiaoqiu Xu, Yidan Chen, Yin Dou, Xing Zhou, Lanlan Li, Chenwen Li, Huijie An, Hui Tao, Houyuan Hu*, Xiaohui Li and Jianxiang Zhang*, Bioinspired yeast microcapsules loaded with self-assembled nanotherapies for targeted treatment of cardiovascular disease. Materials Today, 2017,20(6): 301-313.
2. Xing Zhou, Xiangjun Zhang (co-first author), Songling Han, Yin Dou, Mengyu Liu, Lin Zhang, Jiawei Guo, Qing Shi, Genghao Gong, Ruibing Wang, Jiang Hu*, Xiaohui Li*, and Jianxiang Zhang*, A yeast microcapsule-mediated targeted delivery of diverse nanoparticles for imaging and therapy via the oral route. Nano Letters, 2017, 17(2),1056-1064.
3. Xiangjun Zhang, Qian Cheng, Lanlan Li, Liqing Shangguan, Chenwen Li, Shengke Li, Feihe Huang, Jianxiang Zhang* and Ruibing Wang*, Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent. Theranostics, 2019, 9(11):3107-3121.
4. Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lanlan Li, Jianxiang Zhang* and Ruibing Wang*, A Synthetic Receptor as a Specific Antidote for Paraquat Poisoning. Theranostics, 2019, 9(3):633-645.
5. Hang Yin, Xiangjun Zhang (co-first author), Jianwen Wei, Siyu Lu, David Bardelang and Ruibing Wang*, Recent advances in supramolecular antidotes. Theranostics, 2021, 11(3):1513-1526.
6. Xiangjun Zhang, Qiaoxian Huang, Zhe-ze Zhao, Xiaoqiu Xu, Shengke Li, Hang Yin, Lanlan Li, Jianxiang Zhang* and Ruibing Wang*. An Eco- and User-Friendly Herbicide, Journal of Agricultural and Food Chemistry. 2019, 67(28), 7783-7792.
7. Xiangjun Zhang, Xiaoqiu Xu, Lian-Hui Wang, Jianxiang Zhang* and Ruibing Wang*, A systematic evaluation of the biocompatibility of cucurbit [7] uril in mice. Scientific reports, 2018,8:8819.
8. Yin Dou, Xiangjun Zhang (co-first author), Xiaoqiu Xu, Xing Zhou, Songling Han, Ruibing Wang, Min Su, Xiaohui Li and Jianxiang Zhang*. Multiple noncovalent interactions mediated one-pot therapeutic assemblies for the effective treatment of atherosclerosis. Journal of Materials Chemistry B, 2015,3, 7355-7365.
