PERSONAL INFORMATION
Name: Chao Yu
Gender: Male
Title: Professor
Position: Dean, College of Pharmacy.
CONTACT INFORMATION
Email: yuchao@cqmu.edu.cn
Address: 1 Yixueyuan Road, Yuzhong District, Chongqing
Phone: +86-023-68485161
EDUCATION EXPERIENCE
1981.9-1985.7: BS, Biology, Shaanxi Normal University
1988.9-1991.7: MS, Biochemistry, Sichuan University
2001.9-2004.7: PhD, Clinical Laboratory Diagnostics, Chongqing Medical University
WORKING EXPERIENCE
2016.1 to present Professor, Dean, College of Pharmacy, Chongqing Medical University
2004.9-2015.12 Professor, Executive Vice President, Institute of Life Sciences, Chongqing Medical University
1991.7-2004.9 Associate Researcher, Vice-director, Chongqing Academy of Chinese Materia Medica
2002.10-2003.4 Toyama Medical and Pharmaceutical University and Institute of Chinese Medicine, Japan
1985.7-1988.9 Assistant Professor, Department of Biology, Hanzhong Normal University
RESEARCH INTERESTS
The team led by Professor Yu has long been engaged in research on the mechanism of cardiovascular and cerebrovascular diseases and glycobiology, drug metabolism and kinetics, nanomedicine and biosensing technology for clinical translation and application. In recent years, he has presided over 1 national scientific and technological major project, 3 national projects, 6 provincial and ministerial key projects, and more than 20 other projects at various levels. Professor Yu’s team has innovatively applied micro-nanopremedicine and mechanosensor technology to the non-invasive, rapid and visualized diagnosis and treatment of major diseases, and developed a series of nano-drugs and nano-sensor detection technology by breaking through the traditional means of drug delivery and detection methods and technology in complex systems; in the basic research of cardiovascular diseases, has discovered a new mechanism of regulation of glucose metabolism (especially sialic acid metabolism) and post-translational modification of key functional proteins in the physiological and pathological regulation. The related research results has been published in the top journals of related fields, such as Adv Sci., Autophagy, Chem Eng J., Biomaterials, Biosens Bioelectron, Carbon, ACS Appl Matr Inter、Atherosclerosis、Free Radic Biol Med, etc. totaling more than 200 scientific papers.
HONOUR & AWARDS
1. Chongqing Municipal People's Government, Natural Science Award, Second Prize, Mechanism of Vascular Endothelial Injury by Functional Materials and Construction at Ultrasensitive Electrochemical Sensing Interfaces, 2021 (First Principal)
2. Chongqing Municipal People's Government, Scientific and Technological Progress Award, Third Prize of Provincial Ministry, Research on Peony GAP Standardized Production Technology and Construction of Demonstration Bases, 2008 (Second person in charge)
3. Chongqing Municipal People's Government, Scientific and Technological Progress Award, Third Prize of Provincial Ministry, Research on GAP standardized production technology of Atractylodes macrocephala in Youyang and base construction, 2008 (Second person in charge)
4. Scientific and Technological Achievement Award of Traditional Chinese Medicine, First Prize, Research on GAP standardized production technology and construction of demonstration base of Atractylodes macrocephala in Youyang, 2007 (Second person in charge)
5. Chongqing Municipal People's Government, Scientific and Technological Progress Award, Third Prize of the Ministry of Provincial Affairs, "Research and Development and Industrialization of Pemetrexed Disodium" 2023 (Fourth person in charge)
PUBLICATIONS
1. Peng Xiang, Qingqiu Chen, Le Chen, Jin Lei, Zhiyi Yuan, Hui Hu, Yining Lu, Xianmin Wang, Tingting Wang, Ruihong Yu, Wanping Zhang, Jun Zhang, Chao Yu*, Limei Ma*. Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice. Theranostics. 2023, Vol. 13, Issue 14. doi: 10.7150/thno.87968. (Published)
2. Yunfei Zhao, Yun Li, Fan Wang, Xuelan Gan, Tianye Zheng, Mengyue Chen, Li Wei, Jun Chen*, Chao Yu*. CES1-Triggered Liver-Specific Cargo Release of CRISPR/Cas9 Elements by Cationic Triadic Copolymeric Nanoparticles Targeting Gene Editing of PCSK9 for Hyperlipidemia Amelioration. Advanced Science. 2023 Jul;10(19): e2300502. doi: 10.1002/advs.202300502.
3. Xi Yang, Limei Ma, Jun Zhang; Linmu Chen, Zhen Zou, Di Shen,Hui He, Lei Zhang,Jun Chen, Zhiyi Yuan, Xia Qin, Chao Yu*. Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis. Cell & Bioscience. 2023 Jan 20;13(1):13. doi: 10.1186/s13578-023-00959-y.
4. Xiaoxue Fu, Xiaojuan Yu, Junhao Jiang, Jiaxin Yang, Lu Chen, Zhangyou Yang, Chao Yu*. Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis. Nature Communication. 2022 Nov 1;13(1):6528. doi: 10.1038/s41467-022-34248-y.
5. Yilin Wen, Lu Chen, Li Zhou, Feng Leng, Zhangyou Yang, Chao Yu*. Bionic receptor for atherosclerosis therapy: Molecularly imprinted polymers mediate unique cholesterol efflux and inhibit inflammation. Chemical Engineering Journal. 2022,430(2):132870. Doi: 10.1016/j.cej.2021.132870.
6. Tingrui Zhao, Qingsong Jiang, Wenming Li, Yin Wang, Yao Zou, Xinyu Chai, Zhiyi Yuan, Limei Ma, Ruihong Yu, Tao Deng, Chao Yu*, Tingting Wang*. Antigen-Presenting Cell-Like Neutrophils Foster T Cell Response in Hyperlipidemic Patients and Atherosclerotic Mice. Frontiers in Immunology. 2022 Feb 17;13: 851713. doi: 10.3389/fimmu.2022.851713.
7. Jin Lei, Peng Xiang, Shengmei Zeng, Le Chen, Lei Zhang, Zhiyi Yuan, Jun Zhang, Tingting Wang, Ruihong Yu, Wanping Zhang, Issa Issoufou Ibrahim, Limei Ma*, Chao Yu*. Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation. Front in Pharmacology. 2022 Jan 3;12: 791841. doi: 10.3389/fphar.2021.791841.
8. Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou, Chao Yu*. Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy. 2021 Dec;17(12):4266-4285. doi: 10.1080/15548627.2021.1911016.
9. Zhangyou Yang, Xinwei Fu, Li Zhou, Jiaxin Yang, Tao Deng, Jun Chen, Yilin Wen, Xiaoxue Fu, Di Shen, Zhiyi Yuan, Zaizhi Du, Shenglin Luo*, Chao Yu *, Chem-inspired synthesis of injectable metal–organic hydrogels for programmable drug carriers, hemostasis and synergistic cancer treatment. Chemical Engineering Journal. 2021, 423:130202. doi: 10.1016/j.cej.2021.130202.
10. Chuyi Han, Xianming Zhang, Fan Wang, Qinghua Yu, Feng Chen, Di Shen, Zhangyou Yang, Tingting Wang, Mingyue Jiang, Tao Deng*, Chao Yu*. Duplex metal co-doped carbon quantum dots-based drug delivery system with intelligent adjustable size as adjuvant for synergistic cancer therapy. Carbon.2021, 183:789-808. doi: 10.1016/j.carbon.2021.07.063.
