PERSONAL INFORMATION
Name: Junqing Yang
Gender: Male
Title: Professor
Position: Professor of Phamacology,College of Pharmacy, Chongqing Medical University, Chongqing, PR.China
CONTACT INFORMATION
Email: cqyangjq@cqmu.edu.cn
Address: No. 1 Yixueyuan Road, Yuzhong district, Chongqing 400016, PR.China.
Phone: +86-13637809247
EDUCATION EXPERIENCE
1988.09-1993.06 Medical Department of Chongqing Medical University, Bachelor；
1995.09-1998.06 Department of Pharmacology at Chongqing Medical University, Master；
2001.09-2004.06 Department of Pharmacology at Chongqing Medical University, PhD.
WORKING EXPERIENCE
2006.06-present Professor, Department of Pharmacology, Chongqing Medical University, P.R.China;
2002.010-2006.06 Associate professor, Department of Pharmacology, Chongqing Medical University, P.R.China;
1993.07-2002.10 Lecturer, Department of Pharmacology, Chongqing Medical University, P.R.China.
RESEARCH INTERESTS
The main research field is pharmacology, especially neuopsychopharmacology，antiinflammatory immunopharmacology and pharmacokinetics. Primary research focus is the mechanism and therapeutic drug of CNS disorders including stroke，depression，neurodegenerative disease.
HONOUR & AWARDS
1. National Natural Science Foundation(82173793)，Targeted regulating COX-2 expression by LncRNA-MALAT1/miR-211-5p is involved in the molecular mechanisms of neuronal injury caused by cerebral ischemic and reperfusion, 2022.01.01-2025.12.30.
PUBLICATIONS
1. Meng L, Huang J, He Q, Zhao Y, Zhao W, Tan J, Sun S, Yang J. Hypnotics and infections: disproportionality analysis of the U.S. Food & Drug Administration adverse event reporting system database.J Clin Sleep Med. 2022 Sep 1;18(9):2229-2235.
2. Tu Y Chen Q, Guo W, Xiang P, Huang H, Fei H, Chen L, Yang Y, Peng Z, Gu C, Tan X, Liu X, Lu Y, Chen R, Wang H, Luo Y, Yang J. MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Exp Neurol. 2022 Aug 24;358:114212. doi: 10.1016/j.expneurol.2022.114212.
3. Chen Q, Zheng Q, Yang Y, Luo Y, Wang H, Li H, Yang L, Hu C, Zhang J, Li Y, Xia H, Chen Z, Ma J, Tian X, Yang J. 12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis. Int J Mol Sci. 2022 Aug 12;23(16):8997. doi: 10.3390/ijms23168997.
4. Zhang J, Yao P, Han W, Luo Y, Li Y, Yang Y, Xia H, Chen Z, Chen Q, Wang H, Yang L, Li H, Hu C, Huang H, Peng Z, Tan X, Li M, Yang J. Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Pathway Activation. Int J Mol Sci. 2022 May 30;23(11):6142. doi: 10.3390/ijms23116142.
5. Li Y, Luo W, Zhang J, Luo Y, Han W, Wang H, Xia H, Chen Z, Yang Y, Chen Q, Li H, Yang L, Hu C, Huang H, Peng Z, Tan X, Li M, Yang J. Maternal Inflammation Exaggerates Offspring Susceptibility to Cerebral Ischemia-Reperfusion Injury via the COX-2/PGD2/DP2 Pathway Activation. Oxid Med Cell Longev. 2022 Apr 9;2022:1571705. doi: 10.1155/2022/1571705.
6. Luo W, Yang J.Schizophrenia predisposition gene Unc-51-like kinase 4 for the improvement of cerebral ischemia/reperfusion injury. Mol Biol Rep. 2022 Apr;49(4):2933-2943
7. Meng L, Huang J, Qiu F, Shan X, Chen L, Sun S, Wang Y, Yang J. Peripheral Neuropathy During Concomitant Administration of Proteasome Inhibitors and Factor Xa Inhibitors: Identifying the Likelihood of Drug-Drug Interactions. Front Pharmacol. 2022 Mar 14;13:757415. doi: 10.3389/fphar.2022.757415.
8. Xiang P, Hu J, Wang H, Luo Y, Gu C, Tan X, Tu Y, Guo W, Chen L, Gao L, Chen R, Yang J.miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2. Cell Death Discov. 2022 Feb 28;8(1):89. doi: 10.1038/s41420-022-00885-x.
9. Chen M, Liu M, Luo Y, Cao J, Zeng F, Yang L, Yang J, Tao T, Jiang Y. Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1α/PDK1 Axis. Oxid Med Cell Longev. 2022 Jan 5;2022:7420507. doi: 10.1155/2022/7420507.
10. Tan X, Guo W, Peng Z, Gu C, Xiang P, Tu Y, Fei H, Liu X, Lu Y, Li M, Wang H, Luo Y, Yang J. LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury. Biochem Pharmacol. 2021 Oct;192:114694. doi: 10.1016/j.bcp.2021.114694.
11. Yang Y, Xiang P, Chen Q, Luo Y, Wang H, Li H, Yang L, Hu C, Zhang J, Li Y, Xia H, Chen Z, Yang J. The imbalance of PGD2-DPs pathway is involved in the type 2 diabetes brain injury by regulating autophagy. Int J Biol Sci. 2021 Sep 21;17(14):3993-4004. doi: 10.7150/ijbs.60149.
12. Fei H, Xiang P, Luo W, Tan X, Gu C, Liu M, Chen M, Wang Q, Yang J. CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway. Front Cell Dev Biol. 2021 Aug 4;9:700854. doi: 10.3389/fcell.2021.700854. eCollection 2021.
13 Gu C, Yang J, Luo Y, Ran D, Tan X, Xiang P, Fei H, Lu Y, Guo W, Tu Y, Liu X, Wang H. ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy. Exp Neurol. 2021 Aug;342:113759. doi: 10.1016/j.expneurol.2021.113759.
14. Liu M, Chen M, Luo Y, Wang H, Huang H, Peng Z, Li M, Fei H, Luo W, Yang J（通讯）.. Lipidomic Profiling of Ipsilateral Brain and Plasma after Celastrol Post-Treatment in Transient Middle Cerebral Artery Occlusion Mice Model.Molecules. 2021 Jul 7;26(14):4124. doi: 10.3390/molecules26144124.
15. Li M, Yang J, Cheng O, Peng Z, Luo Y, Ran D, Yang Y, Xiang P, Huang H, Tan X, Wang H. Effect of TO901317 on GF to promote the differentiation of human bone marrow mesenchymal stem cells into dopamine neurons on Parkinson's disease. Ther Adv Chronic Dis. 2021 Mar 19;12:2040622321998139. doi: 10.1177/2040622321998139. eCollection 2021.
16. Luo W, Luo Y, Yang J. Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide. Sci Rep. 2020 Jul 6;10(1):11052. doi: 10.1038/s41598-020-66420-z.
17. Peng Z, Li M, Tan X, Xiang P, Wang H, Luo Y, Yang Y, Huang H, Chen Z, Xia H, Li Y, Zhang J, Gu C, Liu M, Wang Q, Chen M, Yang J. miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2. Biochem Pharmacol. 2020 Jul;177:113983. doi: 10.1016/j.bcp.2020.113983. Epub 2020 Apr 18. PMID: 32311346
18. Chen Z, Yang J, Zhong J, Luo Y, Du W, Hu C, Xia H, Li Y, Zhang J, Li M, Yang Y, Huang H, Peng Z, Tan X, Wang H. MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression. Exp Neurol. 2020 May;327:113223. doi: 10.1016/j.expneurol.2020.113223.
