PERSONAL INFORMATION
NAME: |
Dr. Zhijun ZENG |
|
Gender: |
Male |
Position |
distinguished Associate Professor |
Nationality: |
Chinese |
Tel.: |
(86)15625069758 |
Email: |
zjzeng@cqmu.edu.cn or zhjzeng88@outlook.com |
Address: |
School of Public Health, Chongqing Medical University, 61 Daxuechengzhong Road, Shapingba District, 401331, Chongqing City, P.R.China |
EDUCATION EXPERIENCE
2016/06-2020/05 |
Ph.D., Pathology, University Medical Center Groningen, University of Groningen, the Netherlands |
2012/09-2015/06 |
M.Sc., Immunity, Shantou University Medical College, China |
2007/09-2011/06 |
B.Sc., Bioengineering, College of Life Science, Yangtze University, China |
WORKING EXPERIENCE
2022/11-present |
distinguished Associate Professor, School of Public Health, Chongqing Medical University |
2020/09-2022/10 |
Postdoctoral fellow, School of Environment, Jinan University |
2020/06-2020/09 |
Research assistant, School of Environment, Jinan University |
2015/06-2015/11 |
Research assistant, Shantou University Medical College |
RESEARCH INTERESTS
Population research, epigenetic mechanism concerning the effects of early-life exposure to hazardous environmental pollutants on the growth and development of newborns and children.
Mouse model research, epigenetic mechanism concerning the effects of exposure to prenatal/postnatal smoking on the growth, development, injury and repair of lung tissue in mice.
Clinical research, pathogenesis of chronic obstructive pulmonary disease (COPD), epigenetic mechanism on the repair function of lung epithelial cells.
RESEARCH FUNDINGS
1. Research start-up funds for High-level Talent introduced by Chongqing Medical University, 2022, 350,000 RMB, Principal investigator
2. 2021/09-2023/08, China Postdoctoral Science Foundation (70th), “The epigenetic effect of exposure to PAHs on preschool children’s growth via GH-IGF1 axis” (2021M701430), 80,000 RMB, Principal investigator
3. 2020/10-2023/09, Guangdong Provincial Basic and Applied Basic Research Fund, Regional Joint Fund for Youth, “The epigenetic mechanism of maternal exposure to PM2.5-PAHs during pregnancy with birth outcome via GH-IGF1 axis” (2020A15110858), 100,000 RMB, Principal investigator
4. 2017/01-2018/12, JAN KORNELIS DE COCK-STICHTING (to Zhijun Zeng)，The effect of prenatal and/or postnatal smoke exposure on epigenetic changes in the IGF axis in the lung, € 6,000, Principal investigator
5. 2020/08-2022/07, International Scientific and Technological Cooperation Projects of Guangdong Province, “Environmental-pollutant exposure, low-grade inflammation and related metabolomics changes, and further risk for cardiovascular disease” (2020A05510043), 500,000 RMB, Major program participant
6. Stichting Astma Bestrijding, Reprogramming of Alveolar Epithelial Cell type 2 gene expression using Epigenetic Editing. 2017/03-2019/03, € 25,000，Program participant
7. 2019/01-2022/12, National Natural Science Foundation of China, “Early life exposure to doxin-like compounds increases the susceptibility to diabetes via chronic inflammation” (21876605), 650,000 RMB, Program participant
8. 2016/01-2019/12, National Natural Science Foundation of China, “Effects of co-exposure to chemical pollutants on the development of auditory system in children from an e-waste recycling area” (21577084), 780,000 RMB, Program participant
9. 2015/01-2017/12, Natural Science Foundation of Guangdong Province, “The effect of intrauterine exposure to chemical pollutants on protein expression profile of neonatal umbilical cord tissue” (2015A03031343), 100,000 RMB, Program participant
HONOR & AWARDS
"The Pearl River Talent Plan" Youth Talent Introduction Plan Overseas /Guangdong Overseas Postdoctoral Talent Support Project, 2021-2022
ACADEMIC ACTIVITIES
Reviewer of Environmental Pollution, Environmental Research, Chemosphere, Clinical Epigenetics, Environmental Science and Pollution Research, Environmental Toxicology, etc.
INVITED TALKS
1. Effect of intrauterine exposure to polybrominated diphenyl ethers on protein expression profile of neonatal umbilical cord tissue, The 2nd National Youth Forum on analytical toxicology, Wuxi, China, October 8-10, 2021
2. Association analysis of high lead and cadmium exposure and IL-10 and IL-13 gene polymorphisms and the effects on their expressions in children from an e-waste polluted area, The Sixth Conference on environmental pollution and health, Guangzhou, China, October 16-19, 2021
PUBLICATIONS
1. Zeng Z, Huo X, Wang Q, Wang C, Hylkema MN, Xu X. PM2.5-bound PAHs exposure is linked with low plasma insulin-like growth factor 1 levels and reduced child height. Environment International, 2020; 138:105660
2. Zeng Z, Xu X, Wang Q, Zhang Z, Meng P, Huo X. Maternal exposure to atmospheric PM2.5 and fetal brain development: associations with BAI1 methylation and thyroid hormones. Environmental Pollution, 2022; 308:119665
3. Zeng Z, Xu X, Zhu Y, Wang Q, Zhang Y, Huo X. Pb and Cd exposure linked with Il-10 and Il-13 gene polymorphisms in asthma risk relevant immunomodulation in children. Chemosphere, 2022; 294(4):133656
4. Zeng Z, Ngai S#, Wang Q, Liang W, Huo X. Early-life exposure to widespread environmental toxicants and children's health risks: A focus on the post-vaccination antibody potency or immunoglobulin levels. Science of the Total Environment, 2021; 781(6):146714
5. Zeng Z, Huo X#, Zhang Y, Hylkema MN, Wu Y, Xu X. Differential DNA methylation in newborns with maternal exposure to heavy metals from an e-waste recycling area. Environmental Research, 2019; 171:536-545
6. Zeng Z, Meyer KF#, Lkhagvadorj K, Kooistra W, Reinders-Luinge M, Xu X, Huo X, Song J, Plösch T, Hylkema MN. Prenatal smoke effect on mouse offspring Igf1 promoter methylation from fetal stage to adulthood is organ and sex specific. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020; 318(3):L549-L561
7. Zeng Z, Huo X#, Zhang Y, Xiao Z, Zhang Y, Xu X. Lead exposure is associated with risk of impaired coagulation in preschool children from an e-waste recycling area. Environmental Science and Pollution Research, 2018; 25:20670-20679
8. Lin C, Zeng Z#, Xu R, Liang W, Guo Y, Huo X. Risk assessment of PBDEs and PCBs in dust from an e-waste recycling area of China. Science of the Total Environment, 2021, 803(15):150016
9. Wang Y, Wang Q#, Zhou L#, Zeng Z#, Zhao C, You L, Lu X, Liu X, Ouyang R, Wang Y, Xu X, Tian X, Guo Y, Huo X, Xu G. Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes. Science of The Total Environment, 2022, 30:155601
10. Zeng X, Zeng Z, Wang Q, Liang W, Guo Y, Huo X. Alterations of the gut microbiota and metabolomics in children with E-waste lead exposure. Journal of Hazardous Materials, 2022, 434:128842
11. Zheng K, Zeng Z, Tian Q, Huang J, Zhong Q, Huo X. Epidemiological evidence for the effect of environmental heavy metal exposure on the immune system in children. Science of The Total Environment, 2023, 868:161691
12. Zheng K, Zeng Z, Huang J, Tian Q, Cao B, Huo X. Kindergarten indoor dust metal(loid) exposure associates with elevated risk of anemia in children. Science of The Total Environment, 2022, 851(Pt 1):158227
13. Huang J, Zeng Z, Xu X, Tian Q, Zheng K, Huo X. Blood lead levels of children exposed to e-waste: a systematic review and meta-analysis. Environmental Science and Pollution Research, 2023, 30(24):64860-64871
14. Zheng K, Zeng Z, Lin Y, Wang Q, Tian Q, Huo X. Current status of indoor dust PBDE pollution and its physical burden and health effects on children. Environmental Science and Pollution Research, 2023, 30(8):19642-19661
15. Dai Y, Cheng Z, Zeng Z, Hylkema MN, Faas MM, Huo X. A Targeted Lipidomic Reveals CYP450-Derived Oxylipin Linked to the Inflammatory Response by Polycyclic Aromatic Hydrocarbon Exposure in Children. Exposure and Health, 2022, 15(2):455-466
16. Li M, Pan Y, Hou Z, Wu Z, Zeng Z, Wang B. Plastic or plastic-free life: From formation to removal. Science of the Total Environment, 2023, 890:164359
17. Zheng X, Xu X, Lu F, Wang Q, Zeng Z, Huo X. High serum IgG subclass concentrations in children with e-waste Pb and Cd exposure. Science of the Total Environment, 2021 764:142806
18. Lkhagvadorj K, Zeng Z, Song J, Reinders-Luinge M, Kooistra W, Song S, Krauss-Etschmann S, Melgert BN, Cao J, Hylkema MN. Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2020; 319(4):L742-L751
19. Lkhagvadorj K, Zeng Z, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Plösch T, Hylkema MN. Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation. International Journal of Molecular Sciences, 2020; 22(1):164
20. Wang Q, Xu X, Zeng Z, Hylkema MN, Cai Z, Huo X. PAH exposure is associated with enhanced risk for pediatric dyslipidemia through serum SOD reduction. Environment International, 2020; 145:106132
21. Wang Q, Xu X, Zeng Z, Zheng X, Ye K, Huo X. Antioxidant alterations link polycyclic aromatic hydrocarbons to blood pressure in children. Science of the Total Environment, 2020; 732:138944
22. Zhang Y, Huo X, Lu X, Zeng Z, Faas MM, Xu X. Exposure to multiple heavy metals associate with aberrant immune homeostasis and inflammatory activation in preschool children. Chemosphere, 2020, 257:127257
23. Dai Q, Xu X, Eskenazi B, Asante KA, Chen A, Fobil J, Bergman Å, Brennan L, Sly PD, Nnorom IC, Pascale A, Wang Q, Zeng EY, Zeng Z, Landrigan PJ, Bruné Drisse MN, Huo X*. Severe dioxin-like compound (DLC) contamination in e-waste recycling areas: An under-recognized threat to local health. Environment International, 2020; 139:105731
24. Chen Y, Xu X, Zeng Z, Lin X, Qin Q, Huo X. Blood lead and cadmium levels associated with hematological and hepatic functions in patients from an e-waste-polluted area. Chemosphere, 2019; 220:531-538
25. Wang Q, Xu X, Cong X, Zeng Z, Xu L, Huo X. Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma. Environmental Geochemistry and Health, 2019; 41(1):191-210
26. Cao J, Xu X, Zhang Y, Zeng Z, Hylkema MN, Huo X. Increased memory T cell populations in Pb-exposed children from an e-waste-recycling area. Science of the Total Environment, 2018; 616-617:988-995
27. Lin X, Xu X, Zeng X, Xu L, Zeng Z, Huo X. Decreased vaccine antibody titers following exposure to multiple metals and metalloids in e-waste-exposed preschool children. Environmental Pollution, 2017; 220(Pt A):354-363
