PERSONAL INFORMATION
Name: LIAN Xuemei
Gender: Female
Title: Ph.D.
Position: Professor
CONTACT INFORMATION
Email: xuemeilian@cqmu.edu.cn
Address: No.1 Yixueyuan Rd, Yuzhong District
Phone: +86-68485008
EDUCATION EXPERIENCE
2002.9–2005.7 Ph.D., Pediatrics, Chongqing Medical University
1999.9–2002.7 M.M. (Master of Medicine), Pediatrics, Chongqing Medical University
1990.9–1995.7 B.Sc, Preventive medicine, Hunan Medical University
WORKING EXPERIENCE
1995.7-present Lecturer – Professor, Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University
2011.11-present Professor, Center of Lipid Research, Chongqing Medical School
2015.9-2016.8 Visiting scholar, Department of Environmental Health, University of Cincinnati, Ohio, USA
2010.12-2011.5 Visiting scholar, Lipid Research Unit, Centre for Nephrology, Royal Free Hospital, UCL Medical School, London, UK
2008.11-2010.1 Visiting scholar, Division of Human Genetics, University of Cincinnati, Ohio, USA
2003.3-2005.1 Visiting scholar, Division of Pulmonary Biology, University of Cincinnati, Ohio, USA
RESEARCH INTERESTS
Nutrition and cancer prevention
HONOUR & AWARDS
2020-2023 as Principal Investigator, “Cholesterol metabolites activate LXR pathway and influence lung tumorigenesis”, National Natural Science Foundation of China (NSFC 81973030)
2019 -2022 as Principal Investigator, “The new function of phytosterols in the prevention and treatment of respiratory diseases”, project of Technology Innovation and Application Chongqing, China (cstc2019jscx-msxmX0280)
2019-2020 as Principal Investigator, “Effect of Phytosterols on lung cancer tumorigenesis”, Yihaikerry Nutrition and Food Safety Foundation, Chinese Nutrition Society (CNS-W2018A45)
2013-2015 as Principal Investigator, “Influence of low grade inflammation on cholesterol metabolism in peripheral blood mononuclear cell”, joint project for the Chunhui plan of Ministry of Education, China (Z2012118)
2011-2013 as Principal Investigator, “Influence of high fat diet induced dyslipidemia on susceptibility of lung cancer in mice”, National Natural Science Foundation of China (NSFC 81071907)
2007-2009 as Principal Investigator, “The role of Api6 on macrophage lipid trafficking”, National Natural Science Foundation of China (NSFC 30600660)
PUBLICATIONS
1. Chen T, Song L, Zhong X, Zhu Q, Huo J, Chen J, Tan S, Lian X*. Dietary polyunsaturated fatty acids intake, air pollution, and the risk of lung cancer: A prospective study in UK biobank. Sci Total Environ. 2023 Apr 23;882:163552.
2. Zhu Q, Wu J, Li J, Wang S, He D, Lian X*. Effects of phytosterols' intake on systemic and tissue-specific lipid metabolism in C57BL/6J mice. Front Nutr. 2022 Jul 27;9:924236.
3. Shi D, Wu J, Wu Y, Lin X, Xu C, Lian X*. High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice. Front Oncol. 2021; 11: 620993.
4. Wu J, Wu Y, Lian X*. Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy. Biol Open. 2020; 9(11):bio053298.
5. Gao J, Lin X, He Y, Fu Y, Wu Y, Liao J, Wu Y, Lian X*. The Comparison of Different Obesity Indexes and the Risk of Lung Cancer: A Meta-Analysis of Prospective Cohort Studies. Nutr Cancer. 2019; 71(6):908-921.
6. Lin X, Liu L, Fu Y, Gao J, He Y, Wu Y, Lian X*. Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis. Nutrients. 2018; 10(2). pii: E185.
7. Lin X, Lu L, Liu L, Wei S, He Y, Chang J, Lian X*. Blood lipids profile and lung cancer risk in a meta-analysis of prospective cohort studies. J Clin Lipidol. 2017; 11(4):1073-1081.
8. Chen T, Lu L, Xu C, Lin X, Leung YK, Ho SM, Ruan XZ, Lian X*. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Sci Rep. 2017; 7(1):4723.
9. Xu C, Zhou L, Lu L, Chen T, Wei S, Lin X, Lian X*. Inflammation has a role in urethane induced lung cancer in C57BL/6J mice. Mol Med Rep. 2016; 14(4):3323-8
10. Zhang L, Fang Y, Chen T, Chen K, Lian X*. Role of Api6 in lung inflammation induced by high fat/cholesterol food in C57BL/6J mice. Chinese Journal of Pathophysiology. 2014, 30 (5): 853-858 (Chinese)
11. Chen T, Wang S, Zhang L, Lei X, Wu S, Lian X*. Comparative Study of Lung Cancer Models on BALB/C and C57BL/6J Mice Induced by Multiple Urethane Injections. Sichuan Journal of Zoology. 2014, 33(2): 275-78 (Chinese)
12. Lian X, Yan C, Qin Y, Knox L, Li T and Du H. Neutral Lipids and Peroxisome Proliferator-Activated Receptor-γ Control Pulmonary Gene Expression and Inflammation-Triggered Pathogenesis in Lysosomal Acid Lipase Knockout Mice. Am J Pathol. 2005, 167: 813-821
13. Lian X, Qin Y, Hossain SA, Yang L, White A, Xu H, Shipley JM, Li T, Senior RM, Du H and Yan C. Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury. The Journal of Immunology. 2005, 174 (11): 7250-7256
14. Yang L, Lian X, Cowen A, Xu H, Du H and Yan C. Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor–αin regulation of the surfactant protein B gene in the lung. Molecular Endocrinology.2004; 18 (6):1520-1532 (co-first author)
15. Lian X, Yan C, Yang L, Xu Y and Du H. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am J Physiol Lung Cell Mol Physiol. 2004; 286 (4): L801-L807
16. Li T, Qu P, Wang R, Lian X, Mao Ch, and Dai Y. Effect of vitamin A-fortified biscuits on preschool child in Chong Qing, China. SIGHT AND LIFE. NEWSLETTER 2003（1）: 45-49
