PERSONAL INFORMATION
Name: Fei Han
Gender: Male
Title: Professor
CONTACT INFORMATION
Email: flyskyhf@cqmu.edu.cn
Address: No1 Yixueyuan Road, Yu Zhong District, Chongqing, 400016, China
EDUCATION EXPERIENCE
2014.09-2018.12, Hygienic toxicology, Army Medical University, PhD/MD.
2006.09-2009.06, Biochemistry and Molecular Biology, Southwestern University, Master.
2002.09–2006.06, Biological Science (teaching), Southwest University, Bachelor.
WORKING EXPERIENCE
2022.02 to present, Professor, Chongqing Medical University
2017/12-2022.01, Associate Professor, Army Medical University
2013/09-2017/11, Lecturer, Army Medical University
2009/09-2013/08, Teaching assistant, Army Medical University
RESEARCH INTERESTS
1. Molecular screening, early diagnosis, pathogenesis and precision therapy of tumor disease, and its relationship with environmental pollutants;
2. Epigenetic regulation, pathogenic mechanism and clinical treatment of male infertility, and the microplastic pollution.
HONOUR & AWARDS
The winner of excellent doctoral dissertation of Chongqing, High-end Technology Excellent Professional and Technical Talent; The high-level talent of Chongqing Medical University, the winner of personal Thrid-class Merits, member of the Outstanding Talent Pool of Army Medical University, and the winner of excellent doctoral dissertation of Army Medical University. In the past 5 years, has obtained the National Natural Science Foundation of China 3 items, the Natural Science Foundation of Chongqing 1 item, the outstanding Talents’ Project of Third Military Medical University 1 item, the program for Youth Innovation in Future Medicine of Chongqing Medical University 1 item, and the basic applied research topics of Yunnan Province 1 item; has authorized 3 national invention patents, and has applied for other 3 national invention patents.
PUBLICATIONS
1. Lu C, Liang Y, Cheng Y, Peng C, Sun Y, Liu K, Li Y, Lou Y, Jiang X, Zhang A, Liu J, Cao J, Han F (corresponding author). Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling. Food Chem Toxicol. 2023; 179:113970.
2. Li Y, Zhang Z, Wang J, Liu C, Liu Y, Jiang X, Chen Q, Ao L, Cao J, Sun L, Han F (corresponding author), Liu J. Effects and possible mechanisms of combined exposure to noise and carbon monoxide on male reproductive system in rats. Environ Toxicol. 2023. doi:10.1002/tox.23927.Online ahead of print.
3. Gao P, Sun N, Zhao T, Sun Y, Gu J, Ma D, Tian H, Peng Z, Zhang Y, Han F (corresponding author). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation. 2022, 1:252-269.
4. Han F, Yin L, Jiang X, Zhang X, Zhang N, Yang J, Ouyang W, Hao X, Liu W, Huang Y, Chen H, Gao F, Li Z, Guo Q, Cao J, Liu J. Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation. Aging Cell. 2021; 20 (5):e13343.
5. Gao PP, Qi XW, Sun N, Sun YY, Zhang Y, Tan XN, Ding J, Han F (corresponding author). The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer. Biochim Biophys Acta Rev Cancer. 2021, 1876(1):188562.
6. Sun N, Gao P, Li Y, Yan Z, Peng Z, Zhang Y, Han F (corresponding author), Qi X. Screening and identification of key common and specific genes and their prognostic roles in different molecular subtypes of breast cancer. Front Mol Biosci. 2021, 8:619110.
7. Wang Y, He B, Dong Y, He G, Li Y, Yang Y, Rao Y, Cen Z, Han F (corresponding author), Ding J, Li J. Homeo-box-A13 is a unique prognostic biomarker promoting tumor progression and metastasis by regulating P53 and Wnt/β-catenin signaling pathways in lung adenocarcinoma. Cancer Biomark. 2021; 31(3):239-54.
8. Han F, Jiang X, Li Z, Zhuang X, Zhang X, Ouyang W, Liu W, Mao C, Chen Q, Huang C, Gao F, Cui Z, Ao L, Li Y, Cao J, Liu J. Epigenetic inactivation of SOX30 is associated with male infertility and offers a therapy target for non-obstructive azoospermia, Mol Ther Nucleic Acids. 2020, 19:72-83.
9. Hao X, Gao L, Zhang N, Chen H, Jiang X, Liu W, Ao L, Cao J, Han F (corresponding author), Liu J. Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer. J Exp Clin Cancer Res. 2020, 38:319.
10. Han F, Liu W, Li J, Zhang M, Yang J, Zhang X, Hao X, Yin L, Mao C, Jiang X, Cao J, Liu J. SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer. Endocr Relat Cancer. 2020; 26:303–19.
11. Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CS, Cao J, Liu JY. SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcript- ional and Posttranslational Regulation of β-Catenin in Lung Cancer. EBioMedicine. 2018; 31:253-66.
12. Han F, Zhang M, Liu W, Sun L, Hao X, Yin L, Jiang X, Cao Jia, Liu J. SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients. Respir Res. 2018; 19:241.
13. Yang J, Han F (co-first author), Liu W, Chen H, Hao X, Huang Y, Cao J, Zhang H, Liu J. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. J Exp Clin Cancer Res. 2017, 36:170.
14. Han F, Liu W, Jiang X, Shi X, Yin L, Ao L, Cui Z, Li Y, Huang C, Cao J, Liu J. SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. Oncogene. 2015; 34:4391-402.
15. Han F, Liu W, Xiao H, Dong Y, Sun L, Mao C, Yin L, Jiang X, Ao L, Cui Z, Cao J, Liu J. High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma. Sci Rep. 2015; 5:13630.
16. Liu WB, Han F (co-first author), Jiang X, Yin L, Chen HQ, Liu Y, Cao J, Liu JY. Epigenetic regulation of ANKRD18B in lung cancer. Mol Carcinog. 2015, 54:312-21.
17. Liu WB, Han F (co-first author), Du XH, Jiang X, Li YH, Liu Y, Chen HQ, Ao L, Cui ZH, Cao J, Liu JY. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer. Int J Cancer. 2014,134:1311-22.
18. Hao XL, Han F, Zhang N, Chen HQ, Jiang X, Yin L, Liu WB, Wang DD, Chen JP, Cui ZH, Cao J, Liu JY. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Cell Death Differ. 2019, 26:1235-50.
19. Hao X, Han F, Ma B, Zhang N, Chen H, Jiang X, Yin L, Liu W, Ao L, Cao J, Liu J. SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma. J Exp Clin Cancer Res. 2018, 37:111.
