PERSONAL INFORMATION
Name: Tingwei Zhang
Position: DDS, PhD
Associate Research Fellow | Attending Doctor
Department of Periodontics
Stomatological Hospital of Chongqing Medical University
Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences
Municipal Key Laboratory for Oral Biomedical Engineering of Higher Education
CONTACT INFORMATION
Tel.: +86 17830410609
Email: tingwei_zhang@hospital.cqmu.edu.cn
Address:
426# Songshibei Rd., Yubei District
Chongqing 401147
China
EDUCATION EXPERIENCE
Sichuan University, Sichuan, China
DDS, PhD, 2017
WORKING EXPERIENCE
2022-now Associate Research Fellow, Attending omatological Hospital of Chongqing Medical University, Chongqing, China
2021-2022 Visiting scholar, Peking University, Beijing, China
2018-2021 Post-doctoral Fellow, Stomatological Hospital of Chongqing Medical University, Chongqing, China
2014-2017 Visiting scholar, Craniofacial Center of Molecular Biology, University of South California, CA, USA
HONOURS AND AWARDS
2022/01-2025/12
National Natural Science Foundation (General Program) 82170968
2019/01-2021/12
National Natural Science Foundation (Youth Program) 81800985
2018/02-2021/02
Chinese Postdoctoral Science Foundation (Second Class) 2018M643427
2018/02-2021/02
Chongqing Postdoctoral Science Foundation (Third Class) X11191
RESEARCH INTERESTS
Dr. Zhang is interested in how protein arginine methylation regulates TLR-NFĸB signaling and BMP signaling, which regulate periodontal cell inflammation responses and cell differentiation. Besides, she also focuses on the function of oral MSC extracellular vesicles. In recent years, she also works on the functions of oral-gut axis microbes in oral and systemic diseases.
KEY PUBLICATIONS
1. Lu, M., Zhang, Y., Yuan, X., Zhang, Y., Zhou, M., Zhang, T.*, & Song, J.* (2023). Increased serum α-tocopherol acetate mediated by gut microbiota ameliorates alveolar bone loss through the STAT3 signalling pathway in diabetic periodontitis. Journal of Clinical Periodontology, 1–14.
2. Zhang, Y., Lu, M., Zhang, Y., Yuan, X., Zhou, M., Xu, X., Zhang, T.*, & Song, J.* (2023). Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus. Annals of the New York Academy of Sciences, 00, 1–17.
3. Lingjie Li, Lurong Jia, Siyu Hou, Tingwei Zhang, Mengjiao Zhou, Tao Chen, Jinlin Song. Temporal and spatial effects on C-reactive protein's regulation of inducible nitric oxide synthase production in periodontal disease. J Periodontol. 2023; 1-13.
4. Xulei Yuan, Fuyuan Zhou, He Wang, Xinxin Xu, Shihan Xu, Chuangwei Zhang, Yanan Zhang, Miao Lu, Yang Zhang, Mengjiao Zhou, Han Li, Ximu Zhang, Tingwei Zhang* & Jinlin Song*. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. Int J Oral Sci 15, 4 (2023).
5. Guangyue Li, Han Qin, Mengjiao Zhou, Tingwei Zhang, Yang Zhang, Huifen Ding, Ling Xu, Jinlin Song,Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis, Free Radical Biology and Medicine, Volume 200, 2023,Pages 11-25.
6. Mengjiao Zhou, Xiaohui Xu, Jie Li, Jie Zhou, Yao He, Ziqi Chen, Shan Liu, Duanjing Chen, Han Li, Jiao Huang, Gangyi Yang, Tingwei Zhang* and Jinlin Song*, C-reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat, Journal of Clinical Periodontology, 2022, 1-152.
7. Tingwei Zhang#, Ziqi Chen#, Mengyuan Zhu, Xuan Jing, Xiaohui Xu, Xulei Yuan, Mengjiao Zhou, Yanan Zhang, Miao Lu, Duanjing Chen, Shihan Xu, Jinlin Song*Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis, Genes & Diseases, 2022, doi:10.1016/j.gendis.2022.06.0093.
8. Xuan Jing, Si Wang, Han Tang, Dize Li, Fuyuan Zhou, Liangjing Xin, Qingqing He, Shanshan Hu, Tingwei Zhang*, Tao Chen*, and Jinlin Song*.Dynamically Bioresponsive DNA Hydrogel Incorporated with Dual-Functional Stem Cells from Apical Papilla-Derived Exosomes Promotes Diabetic Bone Regeneration, ACS Applied Materials & Interfaces, 2022, 14 (14)4.
9. Ziqi Chen, Miao Lu, Yanan Zhang, He Wang, Jie Zhou, Mengjiao Zhou, Tingwei Zhang*, Jinlin Song*, Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1, Journal of Periodontal Research, 2022, doi:10.1111/jre.130405.
10. Yongchao Gou, Jingyuan Li, Olan Jackson-Weaver , Jian Wu , Tingwei Zhang, Rahul Gupta, Ihnbae Cho, Thach-Vu Ho, Yibu Chen, Meng Li, Stéphane Richard, Jun Wang, Yang Chai , Jian Xu*, Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis, Journal of Dental Research, 2018, 97(13):1510-15186.
11. Yoko Katsuno#, Jian Qin#, Juan Oses-Prieto, Hongjun Wang, Olan Jackson-Weaver, Tingwei Zhang, Samy Lamouille, Jian Wu, Alma Burlingame, Jian Xu*, Rik Derynck*, Arginine methylation of Smad7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem cell generation, Journal of Biological Chemistry, 2018, 293(34):13059-13072 7.
12. Tingwei Zhang, Jian Wu, Nicha Ungvijanpunya, Olan Jackson-Weaver , Yongchao Gou, Jifan Feng, Thach-Vu Ho, Yudao Shen, Liu Jing, Stéphane Richard, Jian Jin, George Hajishengallis, Yang Chai, Jian Xu*, Smad6 Methylation Repress NFkB Activation and Periodontal Inflammation, Journal of Dental Research, 2018, 97(7):810-819 8.
13. Jifan Feng, Junjun Jing, Jingyuan Li, Hu Zhao, Vasu Punj, Tingwei Zhang, Jian Xu, Yang Chai*, BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice, Development, 2017, 44(14): 2560-25699.
14. Yongchao Gou, Tingwei Zhang, Jian Xu*, Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation, Current Topics in development Biology, 2015, 155: 377-41010.
15. Duanjing Chen, Mingli Xiang, Yuanyuan Gong, Ling Xu, Tingwei Zhang, Yao He, Mengjiao Zhou, Liangjing Xin, Jie Li*, Jinling Song*, LIPUS promotes FOXO1 accumulation by downregulating miR-182 to enhance osteogenic differentiation in hPDLCs, Biochimie, 2019, 165：219-228.11.
16. Shihan Xu, Tingwei Zhang, Zhengguo Cao, Wenjie Zhong, Chuangwei Zhang, Han Li, JInlin Song*, Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights, Frontiers in Immunology, 2021, 12:638400.12.
17. Xu X, Xia X, Yin Y, Yang S, Ai D, Qin H, Zhou M, Song J. Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects. Front Cell Infect Microbiol. 2022 Aug 16;12:953277.13. Wang H, Feng G, Hu B, Tian H, Kuang Y, Zhang T, Song J. Comparison of flash-free and conventional bonding systems: A systematic review and meta-analysis. Angle Orthod. 2022 Jul 14;92(5):691–9.
