PERSONAL INFORMATION
Name: Yang Deqin
Title: Professor, chief physician, Director of endodontic Department
Profile
Yang Deqin，Doctor, doctoral supervisor, post-doctoral cooperative supervisor, and currently the director of the Department of Dentistry and Endodontics of the Affiliated Stomatological Hospital of Chongqing Medical University. Chongqing's first batch of elite programs, famous teachers, Chongqing Bayu Scholar Distinguished Professor, Chongqing's first batch of medical leading talents, Chongqing Medical University's top talent Distinguished Professor, National Excellent Teacher, Academician of the International College of Dentistry in China, Harvard School of Dentistry, USA Returned scholar of Forsyth Research Center, leader of Chongqing key medical discipline and key specialty "Dental and Endodontics". Member of the Standing Committee of the Special Committee of Dentistry and Endodontics of the Chinese Stomatological Association, Member of the Standing Committee of the Special Committee of Oral Biomedicine of the Chinese Stomatological Association, Peer Reviewer of the National Natural Science Foundation of China, Reviewer of the National Science and Technology Award, and Dental and Endodontics of the Chongqing Stomatological Association Chairman of the Professional Committee. Presided over 5 National Natural Science Foundation of China (4 projects) and a number of provincial and ministerial level projects. As the first author and corresponding author, he has published more than 70 papers, including 30 papers included in SCI including "Immunity", and the highest impact factor is 31 points. He has won provincial and ministerial-level science and technology awards for many times, and won two national invention patents. As an associate editor and editorial board member, he participated in editing 5 textbooks and treatises of the National Health Commission's "Twelfth Five-Year Plan" and "Thirteenth Five-Year Plan" plan.
CONTACT INFORMATION
Tel: +86-18723257400
E-mail: 2205677883@qq.com
EDUCATION EXPERIENCE
2007.11-2008.11: Forsyth Research Center, Harvard School of Dentistry, China Scholarship Council
2002.09-2005.06: Full-time doctoral student at West China School of Stomatology, Sichuan University, with a doctorate and degree
2000.09-2002.06: Full-time master student at West China School of Stomatology, Sichuan University, with a master’s degree and academic qualifications
1989.09-1994.06: Full-time undergraduate student at the Department of Stomatology, Zunyi Medical College, with a bachelor's degree and a degree
WORKING EXPERIENCE
2010.11-present :Director of the Department of Dentistry and Endodontics of the Stomatological Hospital Affiliated to Chongqing Medical University, Director of the Department of Dentistry and Endodontics, Professor, Chief Physician, Doctoral Supervisor
1994.7-2010.11: Postgraduate tutor of Zunyi Medical College, director of oral medicine, deputy library director (deputy director level) successively served as teaching assistant, lecturer, associate professor, professor.
RESEARCH FIELD
Oral microecology;Bone cell biology researchDevelopment and regeneration of teeth and related tissues.
PRESIDED OVER SCIENTIFIC RESEARCH PROJECTS
1) The function and mechanism of C1qrl in angiogenesis after maxillofacial injury (31970783) (2019 National Natural Science Foundation of China General Project) under research
2) The cellular and molecular regulation mechanism of intervertebral disc regeneration (31571508) (2015 National Natural Science Foundation of China General Project)
3) Using zebrafish as a model to study the cellular and molecular regulatory mechanisms of tooth regeneration (31371473) (2013 National Natural Science Foundation of China General Project)
4) The relationship between the structural and functional differences of dental plaque and saliva oral microbiome and caries (81170950) (2011 National Natural Science Foundation of China General Project) Conclusion
5) The hypothesis of the continuous flow of dental plaque microorganisms in the etiology of caries (30960419) (2009 National Natural Science Foundation of China)
6) Molecular Basis of Digestive Organ Development (Project 973, 2015CB942800) Sub-project leader and conclusion
7) The person in charge of the sub-project "Technology and Quality Management Standards for Dentistry and Endodontics" of the National Science and Technology Support Program "R&D and Application Demonstration of Key Technologies of Oral Health Service Network Platform" (2015BAH13F02)
8) Research on biomarkers related to salivary gland adenoid cystic carcinoma (Key Project of Yuzhong District Science and Technology Commission 20120201)
9) Research and application of whole-process diagnosis and treatment of caries based on clinical pathway (Chongqing Science and Technology Project 2012) cstc2012gg-yyjs10052
10) Research on the clinical path and quality control of dental caries (sub-project 201002017 of the National Ministry of Health Industry Special Project "Research on the Promotion and Application of the Comprehensive Prevention and Control Mode of Dental Diseases for Urban and Rural Residents")
11) The relationship between plaque biofilm microbiome structure and caries occurrence in different caries-sensitive populations in Chongqing (Chongqing Municipal Health Bureau Medical Research Program Key Project 2011-1-062) Conclusion
12) Research on microbial molecular ecology of plaque biofilms in children with different caries-sensitive children in Chongqing (Chongqing Yubei District Science and Technology Project, Yubei Caijiao [2011] No. 33)
NATIONAL INNOVATION PATENTS
1) Construction method of disc injury model of zebrafish. Authorization No. CN106868043B, approval date: 2020/8/4
2) An anatomical device for animal experiments ", Grant No. CN109589183B, approved date: 2020/10/30
HONOURS & AWARDS
The first batch of Chongqing talents and famous teachers in 2019
The first batch of leading medical talents in Chongqing in 2018
Chongqing Bayu Scholar Distinguished Professor in 2014
Academician of the International College of Dentists in China in 2014
Outstanding Communist Party Member of Chongqing Medical University in 2020
Outstanding Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University in 2020
2020 Director of the Excellent Teaching and Research Section of the Affiliated Stomatological Hospital of Chongqing Medical University
2020 Outstanding Clinical Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University
2020 Second Prize of Ideological and Political Course Design of the Affiliated Stomatological Hospital of Chongqing Medical University
Outstanding Scientific Research Individual of the Affiliated Stomatological Hospital of Chongqing Medical University in 2019
Second Prize of the First Chongqing Residential Training Excellent Courseware Selection in 2019
Leader of Excellent Technology Team of Chongqing Medical University in 2019
2019 Excellent Residential Training and Teaching Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University
2018 Excellent Tutor of the Affiliated Stomatological Hospital of Chongqing Medical University
2018 Director of Excellent Teaching and Research Section of the Affiliated Stomatological Hospital of Chongqing Medical University
Outstanding Party Worker of the Party Committee of the Affiliated Stomatological Hospital of Chongqing Medical University in 2018
2017 Excellent Tutor of the Affiliated Stomatological Hospital of Chongqing Medical University
2017 Director of Excellent Teaching and Research Section of the Affiliated Stomatological Hospital of Chongqing Medical University
Outstanding Party Worker of the Party Committee of the Affiliated Stomatological Hospital of Chongqing Medical University in 2017
2016 Director of the Excellent Teaching and Research Section of the Stomatological Hospital Affiliated to Chongqing Medical University
Outstanding Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University in 2013
Outstanding Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University in 2012
Outstanding Communist Party Member of the Affiliated Stomatological Hospital of Chongqing Medical University in 2011
Outstanding Teacher of the Affiliated Stomatological Hospital of Chongqing Medical University in 2011
2007 National Outstanding Teacher
2007 National Excellent Counselor
Technology Award
2018-2019 Research Team Leader of the Outstanding Scientific and Technological Team of Chongqing Medical University "Basics and Clinical Applications of Dental Diseases"
2009 Second Prize of Science and Technology Award of Guizhou Medical Association (the first person to complete it)
2008 Zunyi Medical College Excellent Paper Second Prize (first author)
Second Prize of Science and Technology Award of Guizhou Medical Association in 2007 (the fifth finisher)
Second Prize of Science and Technology Award of Guizhou Medical Association in 2007 (4th finisher)
26) 2007 Zunyi City Science and Technology Achievement Third Prize (the first person to complete)
PUBLICATIONS
1) De-Qin Yang， Shengmei Feng, Wei Chen, Haibo Zhao, Christie Paulson，and Yi-Ping Li. V-ATPase subunit (Ac45) regulate osteoclast differentiation, intracellular acidification, lysosome trafficking, and protease exocytosis in osteoclast-mediated bone resorption. Journal of Bone and Mineral Research, 2012, 27(8):1695–1707(封面文章 IF 7.056)
2) Chi Liu, Chuan Wu, Qifen Yang, Jing Gao, Li Li, Deqin Yang*, and Lingfei Luo1*. Macrophages Mediate the Repair of Brain VascularRupture through Direct Physical Adhesion and Mechanical Traction. Immunity, 2016, 44(5):1162-76. doi: 10.1016 (共同通讯作者 IF24.082)
3) Jiang Q, Liu J, Chen L, Gan N and Yang D* . The Oral Microbiome in the Elderly With Dental Caries and Health. Front. Cell. Front Cell Infect Microbiol. 2019 Jan 4;8:442. doi: 10.3389/fcimb.2018.00442. (IF3.5)
4) Yu Y, Liao L, Shao B, Su X, Shuai Y, Wang H, Shang F, Zhou Z, Yang D*, Jin Y*. Knockdown of MicroRNA Let-7a Improves the Functionality of Bone Marrow-Derived Mesenchymal Stem Cells in Immunotherapy. Mol Ther. 2017,25(2),480-493. (IF6.938)
5) Dou L, Li D, Xu T, Tang Y, Yang D*. Root anatomy and canal morphology of mandibular first premolars in a Chinese population. Sci Rep. 2017 Apr 7;7(1):750:1-7. (IF5.228)
6) Li Liao, Yang Yu, Bingyi Shao, Xiaoxia Su, Han Wang, Huijuan Kuang, Huan Jing, Yi Shuai, Deqin Yang*, Yan Jin*.Redundant let-7a suppresses the immunomodulatory properties of bone marrow- -derived mesenchymal stem cells by inhibiting the Fas/FasL system in osteoporosis. [J]The FASEB Journal article. Jan 2018, 32(4):1982-1992 (IF 5.6)
7) Bingyi Shao, Li Liao, Yang Yu, Yi Shuai, Xiaoxia Su,k Huan Jing, Deqin Yang*, and Yan Jin*,Estrogen preserves Fas ligand levels by inhibiting microRNA-181a in bone marrow-derived mesenchymal stem cells to maintain bone remodeling balance. The FASEB Journal article. 2015 , 29(9):3935-44. doi: 10.1096/fj.15-272823.（IF5.48)
8) Yu Y, Chen M, Yang S, Shao B, Chen L, Dou L, Gao J, Yang D.* Osthole enhances the immunosuppressive effects of bone marrow-derived mesenchymal stem cells by promoting the Fas/FasL system. J Cell Mol Med. 2021 Mar 21. Epub ahead of print. doi: 10.1111/jcmm.16459（IF4.5)
9) Xiang K, Chen L, Chen W, Yang D*. Remineralization of dentin induced by a compound of polyamide-amine and chlorhexidine in a resin dentin bonding microenvironment. Ann Transl Med 2021;9(6):472. doi: 10.21037/atm-21-472（IF3.297)
10) Chen W, Jiang Q, Yan G, Yang D*. The oral microbiome and salivary proteins influence caries in children aged 6 to 8 years. BMC Oral Health. 2020,20(1):295. doi: 10.1186/s12903-020-01262-9.
11) Xu Y, Jia YH, Chen L, Gao J, Yang DQ*. Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells. BMC Oral Health. 2021 Mar 20;21(1):141. doi: 10.1186/s12903-021-01505-3.
12) Yuan Xu , Yuhuan Jia , Liang Chen , Wenming Huang , Deqin Yang*. Metagenomic analysis of oral microbiome in young children aged 6-8 y living in a rural isolated Chinese province. [J]Oral Disease. 2018,24(6):1115-1125.
13) Bingyi Shao , Xiaohui Fu , Yang Yu， Deqin Yang*. Regulatory effect of microRNA-181a on FasL expression in BMMSCs and its affect on CD4+T lymphocytes apoptosis in estrogen deficiency-induced osteoporosis. [J] Mol Med Rep. 2018. 18(1):920-930.
14) Lei Dou , Margaret Maria Vanschaayk , Yan Zhang, Xiaoming Fu, Ping Ji, Deqin Yang*.The prevalence of dental anxiety and its association with pain and other variables among adult patients with irreversible pulpitis. [J] BMC Oral Health. 2018,18(1):101
15) Huan Jun, Dou Lei, Yan Qifang, Xu Yuan, Yang Deqin*.Effects of concentrated growth factors on angiogenic properties of dental pulp cells and endothelial cells An in vitro study. [J] Braz. Oral Res. 2018;32:e48.
16) Lei Dou, Jun Luo, Xiaoming Fu, Yin Tang , Jing Gao, Deqin Yang*.The validity of caries risk assessment in young adults with past caries experience using a screening Cariogram model without saliva tests. [J]Int Dent J. 23 Mar 2018, 68(4):221-226.
17) Hongcheng Wang, Lingfei Luo*, Deqin Yang*. Loss of Gspt1l disturbs the patterning of the brain central arteries in zebrafish. Biochem Biophys Res Commun, 2017, 486：156-162
18) Yu Y, Zhao T , Yang D*. Co-transfer of Regulatory T Cells improve the therapeutic effectiveness of Mesenchymal Stem Cells in treating colitis mice model.Exp. Anim. 2017,66(2), 167–176
19) Chen J, He J, Li L, Yang D*, Luo L*. Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Sci Rep. 2016 May 20;6:26608：1-9. doi: 10.1038/srep26608. ( IF5.228)
20) Du J , Yang Q , Luo L* , Yang D*. C1qr and C1qrl redundantly regulate angiogenesis in zebrafish through controlling endothelial Cdh5. Biochem Biophys Res Commun, 2017(483) 482-487
21) Chen L, Kleverlaan CJ, Liang K, Yang D*. Effect of polyvinyl siloxane impression material on the polymerization of composite resin. J Prosthet Dent. 2017，117(4):552-558.
22) AH Luo;DQ Yang* J Qin, BC Xin, BJ Paster,. Microbial profile in saliva from children with and with -out caries in mixed dentition.Oral Diseases, 2012, 18（6）:595-601
23) BC Xin, AH Luo, J Qin, BJ Paster, YL Xu, YL Li, DQ Yang*. Microbial diversity in the oral cavity of healthy Chinese Han children. Oral Diseases, 2013, 19（8）:401-405
24) Yang DeQin, Liu TianJia, Cao FuXian. An immunization experimental study of gene vaccines pcDNA3-pac and pcDNA3-gtfB of Streptococcus mutans against dental caries in rats. J Dent Res, 2003，82 (Spec Iss C): 348
25) L. Dou, J. Luo, D. Yang. Anaesthetic efficacy of supplemental lingual infiltration of mandibular molars after inferior alveolar nerve block plus buccal infiltration in patients with irreversible pulpitis. International Endodontic Journal, 2013,46(7):660-5.
