PERSONAL INFORMATION
Name: Jinlin Song
Title: DDS, PhD
Position: Professor of Stomatological Hospital of Chongqing Medical University
Vice Dean of Stomatological Hospital of Chongqing Medical University
College of Stomatology, Chongqing Medical University
Profile:
Prof. Song received his PHD from the West China Hospital of Stomatology in Sichuan University in 2001. His professional career began as the director of orthodontics Stomatological Hospital of Chongqing Medical University in 2003, and served as Vice Dean since 2013.
In addition to leading Stomatological Hospital of Chongqing Medical University as its Vice Dean, Prof. Song has made contributions in research to the specialty of periodontal regeneration with interests in LIPUS function and periodontitis with diabetes and bone restoration material.
Prof. Song has received numerous honors during his academic career, including Member of the stomatology teaching steering committee of the Ministry of Education，deputy director member of Chinese Dental Association Orthodontic Committee, Standing Member of Scientific Research Management sub-committee of Chinese Stomatological Association, Fellow of National Natural Science Foundation of China, Fellow of Ministry of Science and Technology Key Research and Development Program Foundation.
CONTACT INFORMATION
Address: 426# Songshibei Road, Yubei District, Chongqing, 401147, P.R. China.
Tel.: +86-23-8886-0026; Fax: +86-23-8886-0222
E-mail address: songjinlin@hospital.cqmu.edu.cn
MAJOR GRANTS
1. The role of low-intensity pulsed ultrasound in promoting periodontal tissue repair based on periodontal tissue engineering technology (National Natural Science Foundation, 2009-2011).
2. Study on periodontal tissue regeneration induced by low intensity pulsed ultrasound in combination with DFCs/BMSCs National Natural Science Foundation, 2016-2019)
3. The mechanism of low-intensity pulsed ultrasound combined with metformin microbubble ultrasound to induce autophagy and promote periodontitis tissue repair (National Natural Science Foundation, 2018-2021).
4. The effects and mechanism of CRP dissociation inhibitor controlled release system on periodontal defects regeneration in periodontitis with diabetes mellitus.(National Natural Science Foundation, 2020-2023).
HONOURS & AWARDS
1. Chongqing Science and Technology Progress of the Ministry of Education, first prize. (2013)
2. China Science and Technology Progress of the Ministry of Education, first prize. (2009)
PATENTS
1. MEDICAL ADHESIVE AND THE PREPARATION METHOD AND USE (PCT/CN2020/076763，The U.S application No.：US17433505；Japanese application No.：JP2021-549446；European application No.：EP20762978.3). Ximu Zhang, Ping Ji, Jinlin Song.
2. Ultrasonic dental disease treatment sleeve. Jinlin Song, 2012-2020, China, ZL200810168839.0
KEY PUBLICATIONS
[1] Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Linjie Li, Fengyi Liu,
Yiqing Lan, Sheng Yang*, Jinlin Song*. pH and Lipase-responsive
Nanocarrier-mediated Dual Drug Delivery System to Treat Periodontitis in Diabetic
Rats. Bioactive materials ，https://doi.org/10.1016/j.bioactmat.2022.02.008
[2] Xiang Liu#, Xiang Mao#, Guo Ye#, Menghong Wang, Yan Zhang, Xiaoqiao Ning, Man Zhao, Jinlin Song*, Yu Shrike Zhang* , Ximu Zhang*. Bioinspired Andrias davidianus-Derived Wound Dressings for Localized Drug-Elution. Bioactive Materials. Accepted.
[3] Ren L, Yang Z, Song J, et al. Involvement of p38 MAPK pathway in low intensity pulsed ultrasound induced osteogenic differentiation of human periodontal ligament cells[J]. Ultrasonics, 2013, 53(3): 686-690.
[4] Wang Y, Chai Z, Zhang Y, et al. Influence of low-intensity pulsed ultrasound on osteogenic tissue regeneration in a periodontal injury model: X-ray image alterations assessed by micro-computed tomography[J]. Ultrasonics, 2014, 54.
[5] Hu B, Zhang Y, Zhou J, et al. Low-Intensity Pulsed Ultrasound Stimulation Facilitates Osteogenic Differentiation of Human Periodontal Ligament Cells[J]. PloS one, 2014, 9: e95168.
[6] Li L, Liu H, Cheng H, et al. CBCT Evaluation of the Upper Airway Morphological Changes in Growing Patients of Class II Division 1 Malocclusion with Mandibular Retrusion Using Twin Block Appliance: A Comparative Research[J]. PloS one, 2014, 9: e94378.
[7] Yang Z, Ren L, Deng F, et al. Low-Intensity Pulsed Ultrasound Induces Osteogenic Differentiation of Human Periodontal Ligament Cells Through Activation of Bone Morphogenetic Protein-Smad Signaling[J]. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014, 33: 865-73.
[8] Zhao J. Comparison of EGF and bFGF Expression In Vivo and their Effect In Vitro[J]. Clinical Microbiology: Open Access, 2015, 04.
[9] Haresh A D, Singh P, Song J. Soft Tissue Thickness Determination Using CBCT in Diverse Medical Disciplines[J], 2015.
[10] Li J, Zheng L, Zeng L, et al. RGD Peptide-Grafted Graphene Oxide as a New Biomimetic Nanointerface for Impedance-Monitoring Cell Behaviors[J]. Journal of Nanomaterials, 2016, 2016: 1-12.
[11] Zhang X, Yang S, Liao Z, et al. Prevalence and care index of early childhood caries in mainland China: Evidence from epidemiological surveys during 1987-2013[J]. Scientific Reports, 2016, 6: 18897.
[12] Liu S, Hu B, Zhang Y, et al. Minimally Invasive Surgery Combined with Regenerative Biomaterials in Treating Intra-Bony Defects: A Meta-Analysis[J]. PloS one, 2016, 11: e0147001.
[13] Gao W, Zheng Y, Wang R, et al. A Smart Phase Transitional and Injectable DOX/PLGA-Fe Implant for Magnetic-Hyperthermia-Induced Synergistic Tumor Eradication[J]. Acta biomaterialia, 2015, 29.
[14] Chen J, Chen Q, Hu B, et al. Effectiveness of alendronate as an adjunct to scaling and root planing in the treatment of periodontitis: A meta-analysis of randomized controlled clinical trials[J]. Journal of Periodontal & Implant Science, 2016, 46: 382.
[15] Li Y, Sun J, Zhang Y, et al. 3D reconstruction images of cone beam computed tomography in dental medicine application: A case study and mini-review[J]. Journal of X-Ray Science and Technology, 2016, 24: 1-8.
[16] Liu S, Zhou J, Zhang X, et al. Strategies to Optimize Adult Stem Cell Therapy for Tissue Regeneration[J]. International Journal of Molecular Sciences, 2016, 17: 982.
[17] Li N, Hu B, Mi F, et al. Preliminary evaluation of cone beam computed tomography in three‑dimensional cephalometry for clinical application[J]. Experimental and Therapeutic Medicine, 2017, 13.
[18] Chen Q, Chen J, Hu B, et al. Submucosal injection of dexamethasone reduces postoperative discomfort after third-molar extraction: A systematic review and meta-analysis[J]. The Journal of the American Dental Association, 2017, 148(2): 81-91.
[19] Zhou J, Hu B, Liu Y, et al. The efficacy of intra-alveolar 0.2% chlorhexidine gel on alveolar osteitis: a meta-analysis[J]. Oral Diseases, 2017, 23(5): 598-608.
[20] Xiang M, Hu B, Liu Y, et al. Changes in airway dimensions following functional appliances in growing patients with skeletal class II malocclusion: A systematic review and meta-analysis[J]. International Journal of Pediatric Otorhinolaryngology, 2017, 97.
[21] Liu Y, Hu B, Zhou J, et al. The Effect of Enamel Matrix Derivative Alone Versus in Combination with Alloplastic Materials to Treat Intrabony Defects: A Meta-analysis[J]. The International Journal of Periodontics & Restorative Dentistry, 2017, 37: e224-e233.
[22] Zhang X, Hu B, Sun J, et al. Inhibitory Effect of Low-Intensity Pulsed Ultrasound on the Expression of Lipopolysaccharide-Induced Inflammatory Factors in U937 Cells[J]. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2017, 36.
[23] Gao X, Wang T, Song J. Orthodontic and surgical management of a patient with severe skeletal Class II deformity and facial asymmetry: A case report with a 5-year follow-up[J]. American Journal of Orthodontics and Dentofacial Orthopedics, 2017, 151: 779-792.
[24] Kuang Y, Hu B, Chen J, et al. Effects of periodontal endoscopy on the treatment of periodontitis[J]. The Journal of the American Dental Association, 2017, 148.
[25] Fu X, Peng C, Li Z, et al. The application of multi-baseline digital close-range photogrammetry in three-dimensional imaging and measurement of dental casts[J]. PLoS ONE, 2017, 12.
[26] Ajmera D, Wang C, Song J, et al. Analysis of dentoalveolar structures with novel corticotomy-facilitated mandibular expansion: A 3-dimensional finite element study[J]. American Journal of Orthodontics and Dentofacial Orthopedics, 2017, 151: 767-778.
[27] Feng G, Wu Y, Yu Y, et al. Periodontal ligament-like tissue regeneration with drilled porous decalcified dentin matrix sheet composite[J]. Oral Diseases, 2018, 24(3): 429-441.
[28] Zhang X, Zhang L, Zhang Y-H, et al. Predicting trend of early childhood caries in mainland China: a combined meta-analytic and mathematical modelling approach based on epidemiological surveys[J]. Scientific Reports, 2017, 7.
[29] Liang G, Li W, Song J. Critical Role of Hardy-Weinberg Equilibrium and Mixed Ethnicity to Avoid Misinterpretation in Genetic Meta-Analysis Study[J]. Journal of the College of Physicians and Surgeons Pakistan, 2017, 27: 384-384.
[30] Li J, Tian W, Song J. Proteomics Applications in Dental Derived Stem Cells[J]. Journal of cellular physiology, 2016, 232.
[31] Wang L, Hu L, Zhou X, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling[J]. Scientific Reports, 2017, 7.
[32] Xia Y, Hu B, Chen J, et al. Association between the IRF6 rs2235371 polymorphism and the risk of nonsyndromic cleft lip with or without cleft palate in Chinese Han populations: A meta-analysis[J]. Archives of Oral Biology, 2017, 84.
[33] Wang Y, Li J, Qiu Y, et al. Low‑intensity pulsed ultrasound promotes periodontal ligament stem cell migration through TWIST1‑mediated SDF‑1 expression[J]. International Journal of Molecular Medicine, 2018, 42.
[34] Sun C, Sun J, Tan M, et al. Pain after root canal treatment with different instruments: A systematic review and meta-analysis[J]. Oral Diseases, 2018, 24.
[35] Tan M, Chai Z, Sun C, et al. Comparative evaluation of the vertical fracture resistance of endodontically treated roots filled with Gutta-percha and Resilon: A meta-analysis of in vitro studies[J]. BMC Oral Health, 2018, 18: 107.
[36] Deng Y, Feng G, Hu B, et al. Effects of Papacarie on children with dental caries in primary teeth: a systematic review and meta-analysis[J]. Int J Paediatr Dent, 2018, 28(4): 361-372.
[37] Tan F-B, Wang C, Dai H-W, et al. Accuracy and reproducibility of 3D digital tooth preparations made by gypsum materials of various colors[J]. The Journal of Advanced Prosthodontics, 2018, 10: 8.
[38] Wang Y, Qiu Y, Li J, et al. Low-intensity pulsed ultrasound promotes alveolar bone regeneration in a periodontal injury model[J]. Ultrasonics, 2018, 90.
[39] Zhao M, Wen X, Li G, et al. The spatiotemporal expression and mineralization regulation of p75 neurotrophin receptor in the early tooth development[J]. Cell Proliferation, 2018, 52: e12523.
[40] Chen D, Gong Y, Xu L, et al. Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs[J]. Cell Proliferation, 2019, 52(2): e12540.
[41] Peng J, Song J, Han J, et al. The relationship between tooth loss and mortality from all causes, cardiovascular diseases, and coronary heart disease in the general population: systematic review and dose-response meta-analysis of prospective cohort studies[J]. Biosci Rep, 2019, 39(1).
[42] Peng J, Song J, Zhou J, et al. Effects of CPAP on the transcriptional signatures in patients with obstructive sleep apnea via coexpression network analysis[J]. Journal of Cellular Biochemistry, 2019, 120.
[43] Li J, Yang H, Lu Q, et al. Proteomics and N-glycoproteomics analysis of an extracellular matrix-based scaffold-human treated dentin matrix[J]. J Tissue Eng Regen Med, 2019, 13(7): 1164-1177.
[44] Yang Z, Gao X, Zhou M, et al. Effect of metformin on human periodontal ligament stem cells cultured with polydopamine-templated hydroxyapatite[J]. European Journal of Oral Sciences, 2019, 127(3): 210-221.
[45] Li L, Yang S, Xu L, et al. Nanotopography on titanium promotes osteogenesis via autophagy-mediated signaling between YAP and β-catenin[J]. Acta Biomaterialia, 2019, 96.
[46] Kuang Y, Hu B, Xia Y, et al. Low-intensity pulsed ultrasound promotes tissue regeneration in rat dental follicle cells in a porous ceramic scaffold[J]. Brazilian Oral Research, 2019, 33.
[47] Wang M, Li J, Ye Y, et al. SHED-derived conditioned exosomes enhance the osteogenic differentiation of PDLSCs via Wnt and BMP signaling in vitro[J]. Differentiation, 2020, 111: 1-11.
[48] Chen D, Xiang M, Gong Y, et al. LIPUS promotes FOXO1 accumulation by downregulating miR-182 to enhance osteogenic differentiation in hPDLCs[J]. Biochimie, 2019, 165: 219-228.
[49] Liu S, Zhou M, Li J, et al. LIPUS inhibited the expression of inflammatory factors and promoted the osteogenic differentiation capacity of hPDLCs by inhibiting the NF-kappaB signaling pathway[J]. J Periodontal Res, 2020, 55(1): 125-140.
[50] Kuang Y, Hu B, Feng G, et al. Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells[J]. Biogerontology, 2020, 21(1): 13-27.
[51] Xiang M, Zhu M, Yang Z, et al. Dual-Functionalized Apatite Nanocomposites with Enhanced Cytocompatibility and Osteogenesis for Periodontal Bone Regeneration[J]. ACS Biomaterials Science & Engineering, 2020, 6(3): 1704-1714.
[52] Wang Y, Yang K, Li G, et al. p75NTR(-/-) mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/β-catenin pathway[J]. Cell Prolif, 2020, 53(4): e12800.
[53] Outhaisavanh S, Liu Y, Song J. The origin and evolution of the Hawley retainer for the effectiveness to maintain tooth position after fixed orthodontic treatment compare to vacuum-formed retainer: A systematic review of RCTs[J]. Int Orthod, 2020, 18(2): 225-236.
[54] Zhao M, Wang Y, Li G, et al. The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells[J]. Cell Prolif, 2020, 53(2): e12758.
[55] Y L, B H, G F, et al. Association of interleukin-10-1082 (-1087) A > G polymorphisms and periodontitis risk: An updated meta-analysis based on 26 case-control studies[J]. Annals of human genetics, 2019, 83(5): 299-309.
[56] Li Y, Feng G, Deng Y, et al. Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies[J]. Dis Markers, 2018, 2018: 2645963.
[57] Li Y, Sun C, Feng G, et al. Low-intensity pulsed ultrasound activates autophagy in periodontal ligament cells in the presence or absence of lipopolysaccharide[J]. Archives of Oral Biology, 2020, 117: 104769.
[58] Xu X, Huang J, Fu X, et al. Short implants versus longer implants in the posterior alveolar region after an observation period of at least five years: A systematic review and meta-analysis[J]. J Dent, 2020: 103386.
[59] Li Y, Fu Y, Zhang H, et al. FITC-Labeled Alendronate as an In Vivo Bone pH Sensor[J]. Biomed Res Int, 2020, 2020: 4012194.
[60] Ying S, Tan M, Feng G, et al. Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress[J]. Theranostics, 2020, 10(21): 9789-9807.
[61] Yang G, Song J, Zhang J. Biomimetic and bioresponsive nanotherapies for inflammatory vascular diseases[J]. Nanomedicine (Lond), 2020, 15(20): 1917-1921.
[62] Li H, Deng Y, Tan M, et al. Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response[J]. Stem Cell Res Ther, 2020, 11(1): 215.
[63] Li H, Zhou J, Zhu M, et al. Low-intensity pulsed ultrasound promotes the formation of periodontal ligament stem cell sheets and ectopic periodontal tissue regeneration[J]. J Biomed Mater Res A, 2020.
[64] Zhang C, Fan L, Chai Z, et al. Smartphone and medical application use among dentists in China[J]. BMC Med Inform Decis Mak, 2020, 20(1): 213.
[65] Yang G, Wu P, Yu C, et al. Facile Engineering of Anti-Inflammatory Nanotherapies by Host-Guest Self-Assembly[J]. ChemistrySelect, 2020, 5(28): 8707-8716.
[66] Wei J, Huang J, Kuang Y, et al. Metformin inhibits proliferation of oral squamous cell carcinoma cells by suppressing proteolysis of nerve growth factor receptor[J]. Arch Oral Biol, 2021, 121: 104971.
[67] Kuang Y, Wang C, Hu B, et al. Biomechanical analysis of reinstating buccally flared maxillary 2nd molars using 3D printing anchorage supports: a 3D finite element study[J]. Comput Methods Biomech Biomed Engin, 2021: 1-12.
[68] Xin L, Yuan S, Mu Z, et al. Histological and Histomorphometric Evaluation of Applying a Bioactive Advanced Platelet-Rich Fibrin to a Perforated Schneiderian Membrane in a Maxillary Sinus Elevation Model[J]. Front Bioeng Biotechnol, 2020, 8: 600032.
[69] Lu J, Sun J, Zou D, et al. Graphene-Modified Titanium Surface Enhances Local Growth Factor Adsorption and Promotes Osteogenic Differentiation of Bone Marrow Stromal Cells[J]. Frontiers in bioengineering and biotechnology, 2021, 8: 621788-621788.
[70] Xu S, Zhang T, Cao Z, et al. Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights[J]. Front Immunol, 2021, 12: 638400.
[71] Duan J, Huang Y, Tan X, et al. Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment[J]. Transl Psychiatry, 2021, 11(1): 303.
[72] Zhu M, Zhao M, Hu B, et al. Efficacy of glycine powder air-polishing in supportive periodontal therapy: a systematic review and meta-analysis[J]. J Periodontal Implant Sci, 2021, 51(3): 147-162.
[73] Yang G, Wang W, Song J, et al. Bioresponsive self-illuminating nanoparticles for luminescence imaging of inflammation and oxidative stress[J]. Nanomedicine, 2021.
[74] Sun B, Ying S, Ma Q, et al. Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis[J]. Genes & Diseases, 2021.
[75] Gao X, Cong X, Wang Y, et al. Fabrication of antioxidative and antibacterial surface coatings with metformin-loaded self-assembled multilayers for periodontal regeneration in diabetes mellitus patients[J]. JOURNAL OF MATERIALS SCIENCE, 2021,56(33):18668-18683.
[76] Ying S, Tan M, Feng G, et al. Low-intensity Pulsed Ultrasound regulates alveolar bone homeostasis in experimental Periodontitis by diminishing Oxidative Stress[J]. THERANOSTICS, 2022,12(3):1337-1340.
[77] Li H, Zhou H, Song J, et al. Low-intensity pulsed ultrasound promotes the formation of periodontal ligament stem cells sheets and ectopic periodontal tissue regeneration[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2022.
[78] Wang Y, Li J, Zhou J, et al. Low-intensity pulsed ultrasound enhances bone marrow-derived stem
cells-based periodontal regenerative therapies[J]. Ultrasonics, 2022.
