PERSONAL INFORMATION
Name: Jie Li
Gender: Male
CONTACT INFORMATION
Email: jieli@hospital.cqmu.edu.cn
Address: 426# Songshibei Road, Yubei District, Chongqing, 401147, P.R. China.
EDUCATION EXPERIENCE
2005.9-2009.6 BS, Biotechnology, Jiujiang University
2009.9-2012.6 MS, Biochemistry and Molecular Biology, Sichuan University
2012.9-2016.6 PhD, Biochemistry and Molecular Biology, Sichuan University
WORKING EXPERIENCE
2020.10 to present Research Associate Professor, Chongqing Medical University
2016.7-2020.10 Research Assistant Professor, Chongqing Medical University
RESEARCH INTERESTS
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue regeneration and homeostasis. We are interested in the regulatory mechanisms that maintain and regenerate bone and tooth during homeostasis and repair. We hypothesize that a better understanding of these mechanisms will enable us to develop better approaches for treating bone and tooth related diseases in patients. Our work has the following three lines of research related to MSCs:
1. Understanding the transcriptional and translational regulating network of osteogenic/odontogenic differentiation of MSCs in both physiological and pathological situations.
2. Developing bone and tooth tissue engineering strategies based on MSCs and novel biomaterials.
3. Translational application of in-vitro-expanded MSCs in inflammatory diseases.
HONOUR & AWARDS
1. Young Scholars of “Bayu Scholars”
2. Chongqing Young and Middle-aged Talents in Medicine
PUBLICATIONS
1. Pingmeng Deng, Jing Huang, Qixuan Zhang, Yuejia Li, Jie Li*. The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells. BMC Oral Health. 2023 Apr 6;23(1):203.
2. Jiawei Tang, Miao Tan, Siqi Liao, Mengwei Pang, Jie Li*. Recent progress in the biology and physiology of BMP-8a. Connect Tissue Research. 2023 Jan 2:1-10.
3. Hanyue Li, Yu Yuan, Hongying Chen, Hongwei Dai*, Jie Li*. Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway. Molecular Metabolism. 2022 Oct 18;66:101617.
4. He Wang, Xiaowei Chang, Qian Ma, Boyang Sun, Han Li, Jinmin Zhou, Yiyao Hu, Xiaoyu Yang, Jie Li*, Xin Chen*, Jinlin Song*. Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. Bioactive Materials. 2022 Sep 14;21:324-339.
5. Hanyue Li, Hongwei Dai, Jie Li*. Immunomodulatory properties of mesenchymal stromal/stem cells: The link with metabolism. Journal of Advanced Research. 2023 Mar;45:15-29.
6. Yu Yuan, Xiaonan Zhang, Yuzhen Zhan, Song Tang, Pingmeng Deng, Zhenxiang Wang, Jie Li*. Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture. Stem Cell Research & Therapy. 2022 Jun 3;13(1):234..
7. Yungang He, Pingmeng Deng, Ying Yan, Luying Zhu, Hongying Chen, Ting Li, Yong Li*, Jie Li*. Matrisome provides a supportive microenvironment for oral squamous cell carcinoma progression. Journal of Proteomics. 2022 Feb 20;253:104454.
8. Boyang Sun, Siqi Ying, Qian Ma, Han Li, Jie Li*, Jinlin Song*. Metformin ameliorates HMGB1-mediated oxidative stress through mTOR pathway in experimental periodontitis. Genes & Diseases. 2021 Jun 30;10(2):542-553.
9. Han Li, Jie Zhou, Mengyuan Zhu, Siqi Ying, Lingjie Li, Duanjing Chen, Jie Li*, Jinlin Song*. Low-intensity pulsed ultrasound promotes the formation of periodontal ligament stem cell sheets and ectopic periodontal tissue regeneration. Journal of Biomedical Materials Research Part A. 2021 Jul;109(7):1101-1112.
10. Siqi Ying, Minmin Tan, Ge Feng, Yunchun Kuang, Duanjing Chen, Jie Li*, Jinlin Song*. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress. Theranostics. 2020 Aug 1;10(21):9789-9807.
