Faculty & Research

College of Stomatology -- DOU Lei

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PERSONAL INFORMATION

Name: Lei Dou

Position: Associate professor/ associate chief physician


Lei Dou, male,

Doctor’s degree, associate chief physician/associate professor, research supervisor.

work in the department of Conservative dentistry and Endodontics, Stomatological Hospital of Chongqing Medical University.

Visiting scholar, Wake forest institute of regenerative medicine,

Member of Chinese Stomatological Association

Young member of the committee of Conservative dentistry and Endodontics, Chinese Stomatological Association

Member of the committee of Gerontology, Chinese Stomatological Association

Member and secretary of the committee of Conservative dentistry and Endodontics, Chongqing Stomatological Association

I am proficient in the treatment of dental pulp diseases, and good at microscopic root canal therapy, tooth bleaching, inlay and onlay restoration, dual-wavelength laser therapy, microscopic endodontic surgery, vital pulp preservation therapy as well as dental pulp revascularization, etc.  

The research interest is dental pulp tissue engineering and pulp stem cell biology.

So far, I have hosted 6 scientific research projects and 1 educational reform project. I have published more than 20 scientific articles in international or national academic journal, including 11 SCI papers and 3 CSCD papers as the first author or corresponding author. I was granted 2 national invention patents. I am a reviewer of Cellular and Molecular Life Sciences.


CONTACT INFORMATION

Tel: +86-15922666870   

E-mail: 500355@hospital.cqmu.edu.cn


EDUCATION EXPERIENCE 

2003 Sep-2008 Jun   Bachelor’s Degree Stomatology   Sichuan University,

2008 Jul-2010 Jun   Master’s Degree Stomatology   Sichuan University,

2014 Sep-2017 Dec   Doctor’s Degree   Clinical Laboratory Science Chongqing medical university


WORKING EXPERIENCE

2010 Jun- present  Stomatological  Hospital  of  Chongqing Medical University  Department of Conservative dentistry and Endodontics Dentist


RESEARCH INTEREST

Pulp biology, Dental pulp regeneration, Dental stem cell


HONORS & AWARDS

  1. Year 2021 Outstanding communist party member in Stomatological Hospital of Chongqing Medical University

  2. Year 2021 Excellent doctor in Stomatological Hospital of Chongqing Medical University


PUBLICATIONS

  1. Xu X, Li Z, Ai X, Tang Y, Yang D, Dou L. Human three-dimensional dental pulp organoid model for toxicity screening of dental materials on dental pulp cells and tissue. Int Endod J. 2022;55(1):79-88.

  2. Matz EL, Thakker PU, Gu X, Terlecki RP, Dou L, Walker SJ, Lue T, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Administration of secretome from human placental stem cell-conditioned media improves recovery of erectile function in the pelvic neurovascular injury model. J Tissue Eng Regen Med. 2020;14(10):1394-1402.

  3. Guo H, Deng N, Dou L, Ding H, Criswell T, Atala A, Furdui CM, Zhang Y. 3D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening. ACS Biomater Sci Eng 2020;612(12):6701-6709.

  4. Dou L, Yan Q, Yang D. Effect of five dental pulp capping agents on cell proliferation, viability, apoptosis and mineralization of human dental pulp cells. Experimental and Therapeutic Medicine. 2020;19(3): 2377–2383.

  5. Dou L, Matz EL, Gu X, Shu F, Paxton J, Song J, Yoo J, Atala A, Jackson J, Zhang Y. Non-Invasive Cell Tracking with Brighter and Red-Transferred Luciferase for Potential Application in Stem Cell Therapy. Cell Transplant. 2019;28(12):1542-1551.

  6. Jun H, Lei D, Qifang Y, Yuan X, Deqin Y. Effects of concentrated growth factors on the angiogenic properties of dental pulp cells and endothelial cells: an in vitro study. Braz Oral Res. 2018;32:e48.

  7. Dou L, Vanschaayk MM, Zhang Y, Fu X, Ji P, Yang D. The prevalence of dental anxiety and its association with pain and other variables among adult patients with irreversible pulpitis. BMC Oral Health. 2018;18(1):101.

  8. Dou L, Luo J, Fu X, Tang Y, Gao J, Yang D. The validity of caries risk assessment in young adults with past caries experience using a screening Cariogram model without saliva tests. Int Dent J. 2018 68(4):221-226.

  9. Dou L, Yan Q, Liang P, Zhou P, Zhang Y, Ji P. iTRAQ-Based Proteomic Analysis Explore the Influence of Hypoxia on the Proteome of Dental Pulp Stem Cells under 3d Culture. Proteomics. 2018 Feb;18(3-4).

  10. Dou L, Wu Y, Yan Q, Wang J, Zhang Y, Ji P. Secretome profiles of immortalized dental follicle cells using iTRAQ-based proteomic analysis. Sci Rep. 2017;7(1):7300.

  11. Su L, Liu W, Xie B, Dou L, Sun J, Wan W, Fu X, Li G, Huang J, Xu L. Toothbrushing, Blood Glucose and HbA1c: Findings from a Random Survey in Chinese Population. Sci Rep. 2016;6:28824.

  12. Dou L, Li D, Xu T, Tang Y, Yang D. Root anatomy and canal morphology of mandibular first premolars in a Chinese population. Sci Rep. 2017;7(1):750.    

  13. Liu J, Luo J, Dou L, Yang D. CBCT study of root and canal morphology of permanent mandibular incisors in a Chinese population. Acta Odontol Scand. 2014;72(1):26-30.    

  14. Dou L, Luo J, Yang D. Anaesthetic efficacy of supplemental lingual infiltration of mandibular molars after inferior alveolar nerve block plus buccal infiltration in patients with irreversible pulpitis. Int Endod J. 2013;46(7):660-5.    

  15. Dou L, Luo J, Yang D, Wang Y. The effectiveness of an additional lingual infiltration in the pulpal anesthesia of mandibular teeth: a systematic review. Quintessence Int. 2013;44(5):457-64.