PERSONAL INFORMATION
Name: CHEN Chang
Gender: Male
Title: Dr.
Position: Associate Professor
CONTACT INFORMATION
Email: chenchang@cqmu.edu.cn
Address: 1 Yixueyuan Rd, Yuzhong District, Chongqing.
Phone: +86-23-63664754
EDUCATION EXPERIENCE
2002–2006: Bachelor in biopharmaceutics, Huazhong University of Science and Technology, China.
2006–2008: Master in pharmaceutical chemistry, Huazhong University of Science and Technology, China.
2009–2013: PhD in pharmacology, University of Adelaide, Australia, Australia.
WORKING EXPERIENCE
2014–2016: Postdoc in pharmaceutical analysis at Huazhong University of Science and Technology, China.
2016–present: Lecturer, associate professor and associate researcher at Chongqing Medical University, China.
RESEARCH INTERESTS
1. Development and application of metabolomic methods based on liquid chromatography-mass spectrometry.
2. Metabolism and transportation in maternal-fetal medicine.
PUBLICATIONS
1. Yun Li, Dan Zhang, Yan Mo, Teng Zeng, Tongzhi Wu, Lingqiao Liu, Hua Zhang*, Chang Chen*. Simultaneous determination of sex hormones and bile acids in rat plasma using a liquid chromatography- tandem mass spectrometry method. Journal of Pharmaceutical and Biomedical Analysis (2023), 115139. doi: 10.1016/j.jpba.2022.115139
2. Qingzhu Gao#, Bin Cheng#, Chang Chen#, Chong Lei#, Xue Lin, Dan Nie, Jingjing Li, Luyi Huang, Xiaosong Li, Kai Wang*, Ailong Huang*, Ni Tang*. Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway Clinical and Translational Medicine (2022), 12(8): e995. doi: 10.1002/ctm2.995
3. Xuyi Wang #, Chang Chen#, Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Zilin Sun, Tongzhi Wu. Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2h plasma glucose in individuals without diabetes. Diabetes Obesity & Metabolism (2022), 24(6): 1132-1142. doi: 10.1111/dom.14683.
4. Jianan Zhu, Guangmin Song, Xiaobo Zhou, Ting-Li Han, Xinyang Yu, Hao Chen, Toby Mansell, Boris Novakovic, Philip N. Baker, Richard D. Cannon, Richard Saffery, Chang Chen*, Hua Zhang*. CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion. Frontiers in Immunology (2022), 13:813218. doi: 10.3389/fimmu.2022.813218.
5. Jin Xiang#, Chang Chen#, Rui Liu#, Dongmei Gou#, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang*, Kai Wang* & Ni Tang*. Gluconeogenic enzyme pck1 deficiency promotes chk2 o-glcnacylation and hepatocellular carcinoma growth upon glucose deprivation. Journal of Clinical Investigation (2021), 131(8):e144703. doi: 10.1172/JCI144703.
