PERSONAL INFORMATION
Name: Chen Zhe
Gender: Male
Title: Associate Professor
CONTACT INFORMATION
Email: chenzhe925@cqmu.edu.cn
Address: Shangyi building, Office 912
Phone: +86-15696397518
EDUCATION EXPERIENCE
2009-2013: Bachelor, Bioengineering, Wuhan University of Science and Technology
2013-2016: Master, Biomedical Engineering, Chongqing University
2017-2020: Ph.D., Biomedical Engineering, Chongqing University
WORKING EXPERIENCE
2016-2017: Research assistant, Southwest Hospital
2020-2022: Associate research fellow, Southwest Hospital
2022-Present: Associate professor, Chongqing Medical University
RESEARCH INTERESTS
Chen is a researcher dedicated to hematology. Hematopoietic stem cells (HSCs) can differentiate into all blood cell lineages and are essential for the continuous replenishment of the hematopoietic system. The homeostasis of HSCs is governed by a complex epigenetic network, and Chen focuses on uncovering critical epigenetic factors (chromatin remodelers) that regulate HSC potential and contribute to dysregulated hematopoiesis. Moreover, gene mutations can transform hematopoietic stem and progenitor cells to leukemia stem cells (LSCs), which cause drug resistance and relapse of leukemia. Chen utilizes the library screening method to find novel and efficient targets for LSC elimination, and explores underlying mechanisms.
HONOUR & AWARDS
Outstanding Master Thesis of Chongqing (2017)
PUBLICATIONS
1. Zhe Chen#, Qian Guo#, Shichen Huang, Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu*, Jieping Chen*, Yu Hou*. Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin. Genes & Diseases, 2023;11(1):397-412.
2. Zhe Chen#, Qian Guo#, Guanbin Song*, Yu Hou*. Molecular regulation of hematopoietic stem cell quiescence.Cellular and Molecular Life Science, 2022, 79(4):218.
3. Zhe Chen, Dawei Huo, Lei Li, Zhilong Liu, Zhigang Li, Shuangnian Xu, Yongxiu Huang, Wei Wu, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Feng Wu, Hui Li, Pengxu Qian, Guanbin Song, Xudong Wu*, Jieping Chen*, Yu Hou*. Nuclear DEK preserves hematopoietic stem cells potential via NcoR1/HDAC3-Akt1/2-mTOR axis. Journal of Experimental Medicine, 2021, 218(5): e20201974.
4. Zhe Chen, Lei Li, Weiru Wu, Zhilong Liu, Yongxiu Huang, Li Yang, Qing Luo, Jieping Chen, Yu Hou*, Guanbin Song*. Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis. Theranostics, 2020, 10(14): 6448-6466.
5. Zhe Chen#, Lei Li#, Shuangnian Xu, Zhilong Liu, Chengfang Zhou, Zhigang Li, Yuanyuan Liu, Weiru Wu, Yongxiu Huang, Mei Kuang, Shijun Fan, Hui Li, Xi Li, Guanbin Song, Wen-Shu Wu, Jieping Chen*, Yu Hou*. A Cdh1-FoxM1-Apc axis controls muscle development and regeneration. Cell Death & Disease, 2020, 11(3): 180.
6. Zhe Chen, Nuping Bu, Xiaohong Qiao, Zhixiang Zuo, Yahai Shu, Zhilong Liu, Zhijian Qian, Jieping Chen*, Yu Hou*. Forkhead Box M1 transcriptionally regulates the expression of long noncoding RNA Snhg8 and Gm26917 to promote proliferation and survival of muscle satellite cells. Stem Cells, 2018, 36(7): 1097-1108.
7. Zhe Chen, Qing Luo, Lin Yuan, Guanbin Song*. Microgravity directs stem cell differentiation. Histology and Histopathology, 2017, 32: 99-106.
8. Zhe Chen, Qing Luo, Chuanchuan Lin, Dongdong Kuang, Guanbin Song*. Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede nuclear translocation of TAZ. Scientific Reports, 2016: 30322.
9. Zhe Chen, Qing Luo, Chuanchuan Lin, Guanbin Song*. Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells through down regulating the transcriptional co-activator TAZ. Biochemical and Biophysical Research Communications, 2015, 468(1-2): 21-26.
