PERSONAL INFORMATION
Name: Zufeng Guo
Gender: Male
Title: Professor
CONTACT INFORMATION
Email: zfguo@cqmu.edu.cn
EDUCATION EXPERIENCE
1996.9-2000.7: BS, Chemistry, Fuzhou University
2000.9-2003.7: MS, Analytical Chemistry, Fuzhou University
2004.9-2009.11: PhD, Chemical Biology, The Hong Kong University of Science and Technology
WORKING EXPERIENCE
2010.12-2016.11: Postdoc, Pharmacology, Johns Hopkins University School of Medicine
2016.12-2020.7: Research Associate, Pharmacology, Johns Hopkins University School of Medicine
2020.9 to present Professor, Chongqing Medical University
RESEARCH INTERESTS
Chemical biology and drug discovery
PUBLICATIONS
1. Zheng, J.#; Zhang, W.#; Li, L.#; He, Y.; Wei, Y.; Dang, Y.; Nie, S.*; Guo, Z.F.* Signaling pathway and small-molecule drug discovery of FGFR: A comprehensive review. Front. Chem. 2022, 10:860985.
2. Wang, Y.F.#; Peng, H.J.#; Guo, Z.F.#; Ullman, B.; Yamamoto, K.; Hong, S.Y.; Liu, J.O.* Influence of stereochemistry on the activity of the rapadocin, an isoform-specific inhibitor of nucleoside transporter ENT1. Chem. Sci. 2021, 12 (34): 11484-11489.
3. Wang, X.; Yin, G.*; Zhang, W.; Song, K.; Zhang, L.; Guo, Z.F.* Prostaglandin reductase 1 as a potential therapeutic target for cancer therapy. Front. Pharmacol. 2021, 12: 717730.
4. Guo, Z.F.*; Peng, H.J.; Xie, Y.M. BET family protein degraders poised to join the senolytic arsenal. Signal Transduct. Tar. 2020, 5(1): 88.
5. Liberti, M.V.*; Allen, A.E.; Ramesh, V.; Dai, Z.; Singleton, K.R.; Guo, Z.F.; Liu, J.O.; Wood, K.C.; Locasale, J.W. (2020) Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis. J. Biol. Chem. 2020, 295 (1): 111-124.
6. Guo, Z.F.#; Cheng, Z.Q.#; Wang, J.X.#; Liu, W.K.; Peng, H.J.; Wang, Y.F.; Rao, A.V.S.; Li, R.J.; Ying, X.; Korangath, P.; Liberti, M.V.; Li, Y.J.; Xie, Y.M.; Hong, S.Y.; Schiene-Fischer, C.; Fischer, G.; Locasale, J.W.; Sukumar, S.; Zhu, H.; Liu, J.O.* Discovery of a potent GLUT inhibitor from a library of rapafucins by using 3D microarrays. Angew. Chem. Int. Ed. 2019, 58 (48): 17158-17162.
7. Peiffer, B.J.#; Qi, L. #; Ahmadi, A.R.; Wang, Y.; Guo, Z.F.; Peng, H.; Sun, Z.*; Liu, J.O.* Activation of BMP signaling by FKBP12 ligands synergizes with inhibition of CXCR4 to accelerate wound healing. Cell Chem. Biol. 2019, 26 (5): 652-661.
8. Guo, Z.F.#; Hong, S.#; Wang, J.X.#; Rehan, S.; Liu, W.K.; Peng, H.J.; Das, M.; Li, W.; Bhat, S.; Peiffer, B.; Ullman, B.R.; Tse, C.M.; Tarmakova, Z.; Schiene-Fischer, C.; Fischer, G.; Coe, I.; Paavilainen, V.O.; Sun, Z.L.; Liu, J.O.* (2019) Rapamycin-inspired macrocycles with new target specificity. Nat. Chem. 2019, 11 (3), 254-263.
