PERSONAL INFORMATION
Name: Jun-Yan LIU
Gender: Male
Title: Professor
Position: Principal Investigator (PI)
CONTACT INFORMATION
Email: jyliu@cqmu.edu.cn
Address: R801, Library Bldg.
Phone: +86-23-6848 3587
EDUCATION EXPERIENCE
2000.9-2003.6 Ph.D. Natural Medicinal Chemistry, Nanjing University
1997.9-2000.7 M.S. Phytochemistry, Northwest A & F University
1990.9-1994.6 B.E. Polymer Materials, Nanjing Institute of Chemical & Industrial Technology
WORKING EXPERIENCE
2020.4 - Present, Professor, Institute of Life Sciences, Chongqing Medical University
2016.11-2019.10, Deputy Director, Center for Nephrology & Metabolomics, Tongji University School of Medicine
2014.05-2019.10, Professor, Division of Nephrology and Rheumatology; Shanghai Tenth People’s Hospital, Tongji University School of Medicine
2012.10-2014.4, Sr Research Scientist, Analytical Chemistry & Natural Product Chemistry, Marrone Bio Innovations, CA, USA
2011.03-2012.09, Co-Core Leader of Analytical Core of NIEHS-UCD Superfund Basic Research Program, University of California, Davis CA
2005.5-2012.9, Assistant Research Scientist (2009-2012) and Postgraduate Researcher (2005-2009), Pharmacology, Analytical Chemistry, and Metabolomics, Analytical Core of NIEHS-UCD Superfund Basic Research Program and Department of Entomology, University of California, Davis.
2003.6-2005.5, Postdoctoral fellow & Associate Professor (2005), Natural Product Chemistry and Pharmacology, Nanjing University, Nanjing, China
1994.8-1997.8, Assistant Engineer & Assistant Manager (1997), Chemical Engineering, Nanjing Tianyue Group Corporation, Nanjing, China
RESEARCH INTERESTS
Professor Liu has a long-term interest in the application of mass spectrometry-based metabolomics to pathogenic and pharmacological investigation of multiple diseases, including colorectal cancer, breast cancer, acute kidney injury, chronic kidney disease, and many other chronic diseases. Recently his laboratory focuses on the impact of different diets (high-fat diet, high sugar diet, etc.) on human health through the interaction between metabolome and gut microbiome.
HONOUR & AWARDS
1 Natural Science Award (1st Place), Ministry of Education of the Peoples’ Republic of China, 2008
2 NIEHS Superfund Matching Fund Award, NIEHS-UCD Superfund Basic Research Program
3 ASPET Travel Award, American Society for Pharmacology and Experimental Therapeutics (ASPET)
PUBLICATIONS （# equally contributed authors, * Corresponding author）
1 Xian Fu, Hou-Hua Yin, Ming-Jun Wu, Xin He, Qing Jiang, Ling-Tong Zhang, Jun-Yan Liu*. (2022) High sensitivity and wide linearity LC-MS/MS method for oxylipin quantification in multiple biological samples. Journal of Lipid Research 63(12): e103002
2 Da-Yong Hu #, *, Ming-Yu Wu #, Guang-Qi Chen #, Bing-Qing Deng, Hai-Bo Yu, Jian Huang, Ying Luo, Meng-Yuan Li, Da-Ke Zhao, Jun-Yan Liu*. (2022) Metabolomics analysis of human plasma reveals decreased production of trimethylamine N-oxide retards the progression of chronic kidney disease. British Journal of Pharmacology. 179（17）：4344-4359
3 Cheng Kong #, Xuebing Yan #, Yefei Zhu #, Huiyuan Zhu #, Ying Luo, Peipei Liu, Sylvain Ferrandon, Matthew F Kalady, Renyuan Gao, Jide He, Fang Yin, Xiao Qv, Jiayi Zheng, Yaohui Gao; Qing Wei; Yanlei Ma *, Jun-Yan Liu*, Huanlong Qin* (2021) Fusobacterium Nucleatum Promotes the Development of Colorectal Cancer by Activating a Cytochrome P450/Epoxyoctadecenoic Acid Axis via TLR4/Keap1/NRF2 Signaling. Cancer Research 81 (17): 4485-4498
4 Ying Luo, Ming-Yu Wu, Bing-Qing Deng, Jian Huang, Sung Hee Hwang, Meng-Yuan Li, Chun-Yu Zhou, Qian-Yun Zhang, Hai-Bo Yu, Da-Ke Zhao, Ling Qin, Ai Peng, Guodong Zhang, Bruce D Hammock*, Jun-Yan Liu*. (2019) Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proceedings of the National Academy of Sciences of the United States of America. 116(11):5154-5159
5 Ying Luo, Ling Wang, Ai Peng and Jun-Yan Liu*. (2019) Metabolic profiling of human plasma reveals the activation of 5-lipoxygenase in the acute attack of gouty arthritis. Rheumatology 58： 345-351
6 Dai-Yong Hu#, Ying Luo#, Chang-Bin Li, Chun-Yu Zhou, Xin-Hua Li, Ai Peng, Jun-Yan Liu*. (2018) Oxylipin profiling of human plasma reflects the renal dysfunction in uremic patients. Metabolomics 14: 104
7 Bing-Qing Deng, Ying Luo, Xin Kang, Chang-Bin Li, Christophe Morisseau, Jun Yang, Kin Sing Stephen Lee, Jian Huang, Da-Yong Hu, Ming-Yu Wu, Ai Peng, Bruce D. Hammock*, Jun-Yan Liu*. (2017) Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling. Proceedings of the National Academy of Sciences of the United States of America 114 (47): 12608-12613
8 Jun-Yan Liu*, Christophe Morisseau, Huazhang Huang, Bruce D Hammock. (2016) Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. Journal of Ethnopharmacology 194: 475-482
9 Jun-Yan Liu#, Hsing-Ju Tsai#, Christophe Morisseau, Jozsef Lango, Sung Hee Hwang, Takaho Watanabe, In-Hae Kim, and Bruce D Hammock*. (2015) In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochemical Pharmacology 98(4):718-731
10 Jun-Yan Liu, Ning Li, Jun Yang, Nan Li, Hong Qiu, Ding Ai, Nipavan Chiamvimonvat, Yi Zhu and Bruce D Hammock*. (2010) Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proceedings of the National Academy of Sciences of the United States of America 107: 17017-17022
