PERSONAL INFORMATION
Name: Nie Shenyou
Gender: Male
Title: Professor
Position: Principal Investigator
CONTACT INFORMATION
Email: nieshenyou@cqmu.edu.cn
Address: Room 802, Library, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P.R.China
Phone: +86-68480550
EDUCATION EXPERIENCE
2005.9-2009.7 BS, Pharmacy, Wuhan University
2009.9-2014.7 Ph.D. Organic Chemistry, Shanghai Institute of Organic Chemistry
WORKING EXPERIENCE
2020.9 to present, Professor, Chongqing medical University
2016.7-2020.7 Postdoctoral Associate, Baylor College of Medicine
2015.7-2016.7 Postdoctoral Associate, Purdue University
2014.7-2015.7 Senior Investigator, Shanghai Medicilon Inc.
RESEARCH INTERESTS
1. Medicinal Chemistry: development of small molecule inhibitors and degraders targeting cancer and infectious disease.
2. Organic Chemistry: construction of diverse small molecule compound libraries based on Pseudo natural products employing Ugi reaction and C-H activation/domino strategies.
HONOUR & AWARDS
Chongqing Bayu Talented Young Scholar
PUBLICATIONS
1.Shuang Zhao#, Yi He#, Feiyu Gao#, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun-yan Liu, Zufeng Guo, Zhenghua Li*, Shenyou Nie* Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization. Chem. Commun. 2023, 59, 3099-3102.
2. Shenyou Nie#, Fangrui Wu#, Jingyu Wu#, Xin Li#, Chao Zhou, Yuan Yao, and Yongcheng Song*. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur. J. Med. Chem., 2022, 237,114407.
3. Jin-Pin Liu, Si-Yu Cen, Zian Xue, Tian-Xiang Wang, Yun Gao, Jia Zheng, Cheng Zhang, Junchi Hu, Shenyou Nie, Yue Xiong, Kun-Liang Guan, and Hai-Xin Yuan*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem. Biol. 2022, 17, 3389–3406.
4. Jia Zheng#, Wei Zhang#, Linfeng Li#, Yi He, Yue Wei, Yongjun Dang, Shenyou Nie*, and Zufeng Guo*. Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review. Front. Chem., 2022, doi: 10.3389/fchem.2022.860985.
5. Shenyou Nie#, Yuan Yao#, Fangrui Wu#, Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B. Vogt, Josephine Ferreon, Rebecca Rico-Hesse, and Yongcheng Song*. Synthesis, Structure-Activity Relationships and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Med. Chem.,2021, 64, 2777–2800.
6. Fangrui Wu#, Shenyou Nie#, Yuan Yao#, Tong Huo#, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qiangxing Mo, Yongcheng Song*. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth. Theranostics 2021, 11, 8172-8184.
7. Shenyou Nie#, Jidong Zhao#, Xiaowei Wu#, Yuan Yao#, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, and Yongcheng Song*.Synthesis, Structure-Activity Relationship and Antiviral Activity of Indole-Containing Inhibitors of Flavivirus NS2B-NS3 protease. Eur. J. Med. Chem., 2021, 225, 113767.
8. Shenyou Nie, Wei Li and Biao Yu*. Total Synthesis of Nucleoside Antibiotic A201A. J. Am. Chem. Soc.2014, 136, 4157-4160. (IF= 12.113, JCR 1 区)
9. Yuan Yao#, Tong Huo#, Yi-Lun Lin#, Shenyou Nie#, Fangrui Wu#, Yuanda Hua, Jingyu Wu, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, Yongcheng Song*. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Am. Chem. Soc.2019,141, 6832-6836.
10. Shenyou Nie, Xiaoping Chen, Yuyong Ma, Wei Li*, Biao Yu*. An unexpected rearrangement of pent-4-enofuranosides to cyclopentanones upon hydrogenolysis of the anomeric benzyl group. Carbohydr. Res. 2016, 432, 36-40. (IF= 1.817, JCR 3 区)
11. Fangrui Wu, Yuanda Hua, Salma Kaochar, Shenyou Nie, Yi-Lun Lin, Yuan Yao, Jingyu Wu, Xiaowei Wu, Xiaoyong Fu, Rachel Schiff, Christel M. Davis, Matthew Robertson, Erik A. Ehli, Cristian Coarfa, Nicholas Mitsiades, Yongcheng Song*. Discovery, Structure− Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. J. Med. Chem.,2020,63, 4716-4731.
12. Arun K. Ghosh*, Anne M. Veitschegger, Shenyou Nie, Nicola Relitti, Andrew J. MacRae, and Melissa S. Jurica.Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in vitro Splicing Inhibition. J. Org. Chem.2018, 83, 5187-5198.
